Comparison of clinical outcomes and FOXP3, IL‐17A responses in <i>Helicobacter pylori</i> infection in children versus adults

Yörgüç, Eda; Gülerman, Hacer Fulya; Kalkan, İsmail Hakkı; Güven, Burcu; Balcı, Mahi; Yörgüç, Mustafa Çağlar

doi:10.1111/hel.12795

Cited by 8 publications

(4 citation statements)

References 18 publications

(30 reference statements)

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“…Other studies have reported that the incidence of PUD in children increases with age (10, 12 -14, 16, 18 -20). This was thought to be related to higher rates of Hp infection, which is the risk factor for PUD, most common in older children and adolescents (21).…”

Section: Discussionmentioning

confidence: 99%

Pepti̇k Ülserli̇ Çocuk Hastalarin Değerlendi̇ri̇lmesi̇: Tek Merkez Deneyi̇mi̇

Hoşnut

Tekeli

2022

Kocatepe Tıp Dergisi

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OBJECTIVE: Data on the incidence of peptic ulcer in childhood and risk factors other than Helicobacter pylori (Hp) are insufficient. The aim of this study is to determine the frequency, clinical findings, risk factors and complications of gastroduodenal ulcer in children.MATERIAL AND METHODS: The endoscopy reports and file information of the children who underwent esophagogastroduodenoscopy in our center between May 2011 and December 2018 were reviewed retrospectively.RESULTS: Of the 5892 pediatric patients examined, 448 (7.6%) had peptic ulcers. Of the ulcers evaluated, 69% were duodenal, 27.4% were gastric, and 3.6% were both gastric and duodenal ulcers. The most common (52.2%) symptom was dyspepsia. The most common risk factor in peptic ulcers was Hp (66.5%). Nonsteroidal anti-inflammatory drugs were found to be the second most common (5.8%) risk factor. No risk factor could be demonstrated in 14.95% of the cases. Complications secondary to peptic ulcer disease were detected in 70 (15.7%) of the patients. The complications were; bleeding in 50 (12.7%) patients, gastric outlet obstruction in 11 (2.4%) patients, and perforation in 2 (0.4%) patients.CONCLUSIONS: Helicobacter pylori infection is the most important risk factor for peptic ulcer in children. However, in cases where Hp cannot be demonstrated, other risk factors should be investigated.

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Section: Discussionmentioning

confidence: 99%

Pepti̇k Ülserli̇ Çocuk Hastalarin Değerlendi̇ri̇lmesi̇: Tek Merkez Deneyi̇mi̇

Hoşnut

Tekeli

2022

Kocatepe Tıp Dergisi

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“…Both pathways were overexpressed in the mucosa of H. pylori -positive patients. Children presented an important regulatory response that inhibits inflammation (with higher FOXP3 cells) and significantly lower Th17A levels during H. pylori infection than adults [ 34 ].…”

Section: Pathogenesis Natural History and Clinical Outcome Of The Inf...mentioning

confidence: 99%

Helicobacter pylori Infections in Children

Nguyen,

Kotilea,

Bontems

et al. 2023

Antibiotics

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In the context of epidemiology, host response, disease presentation, diagnosis, and treatment management, the manifestation of Helicobacter pylori (H. pylori) infection diverges between children and adults. H. pylori infection stands out as one of the most prevalent bacterial infections globally, and its prevalence in both children and adults is decreasing in many developing countries but some still struggle with a high prevalence of pediatric H. pylori infection and its consequences. The majority of infected children are asymptomatic and pediatric studies do not support the involvement of H. pylori in functional disorders such as recurrent abdominal pain. The pathophysiology of H. pylori infection relies on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. This interaction gives rise to diverse gastritis phenotypes, which subsequently influence the potential development of various gastroduodenal pathologies. In clinical settings, the diagnosis of this infection in childhood requires an upper gastrointestinal endoscopic exam with mucosal biopsy samples for histology and culture, or Polymerase Chain Reaction (PCR) at the very least. When warranted, eradication treatment should be given when good compliance is expected, and there should be systematic use of a treatment adapted to the antimicrobial susceptibility profile. To combat the burgeoning threat of multidrug resistance, vigilant surveillance of resistance patterns and strategic antibiotic management are paramount.

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“…pylori load in the gastric mucosa, suggesting a role of IL-17–secreting cells in eradicating acute H . pylori infection ( 8 , 9 ). However, the presence of Th17 cells has been linked to more severe gastric inflammation and tumor progression in adult patients ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Metagenomic and single-cell RNA-Seq survey of the Helicobacter pylori–infected stomach in asymptomatic individuals

Sorini¹,

Tripathi²,

Wu³

et al. 2023

JCI Insight

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Helicobacter pylori colonization of the gastric niche can persist for years in asymptomatic individuals. To deeply characterize the host–microbiota environment in H . pylori –infected (HPI) stomachs, we collected human gastric tissues and performed metagenomic sequencing, single-cell RNA-Seq (scRNA-Seq), flow cytometry, and fluorescent microscopy. HPI asymptomatic individuals had dramatic changes in the composition of gastric microbiome and immune cells compared with noninfected individuals. Metagenomic analysis uncovered pathway alterations related to metabolism and immune response. scRNA-Seq and flow cytometry data revealed that, in contrast to murine stomachs, ILC2s are virtually absent in the human gastric mucosa, whereas ILC3s are the dominant population. Specifically, proportion of NKp44 + ILC3s out of total ILCs were highly increased in the gastric mucosa of asymptomatic HPI individuals, and correlated with the abundance of selected microbial taxa. In addition, CD11c + myeloid cells and activated CD4 + T cells and B cells were expanded in HPI individuals. B cells of HPI individuals acquired an activated phenotype and progressed into a highly proliferating germinal-center stage and plasmablast maturation, which correlated with the presence of tertiary lymphoid structures within the gastric lamina propria. Our study provides a comprehensive atlas of the gastric mucosa–associated microbiome and immune cell landscape when comparing asymptomatic HPI and uninfected individuals.

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Comparison of clinical outcomes and FOXP3, IL‐17A responses in Helicobacter pylori infection in children versus adults

Cited by 8 publications

References 18 publications

Pepti̇k Ülserli̇ Çocuk Hastalarin Değerlendi̇ri̇lmesi̇: Tek Merkez Deneyi̇mi̇

Pepti̇k Ülserli̇ Çocuk Hastalarin Değerlendi̇ri̇lmesi̇: Tek Merkez Deneyi̇mi̇

Helicobacter pylori Infections in Children

Metagenomic and single-cell RNA-Seq survey of the Helicobacter pylori–infected stomach in asymptomatic individuals

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