Comparison of clinical manifestations in mpox patients living with HIV versus without HIV: A systematic review and meta‐analysis

Abstract

Currently, many cases of mpox patients living with the human immunodeficiency virus (HIV) have been reported. Immunocompromised mpox patients, including those living with HIV are noted for an increased risk for severe symptoms; however, existing studies did not focus on the statistical comparison of mpox outcomes associated with HIV. Thus, we conducted a systematic review and meta-analysis to evaluate and compare the clinical manifestations of mpox in people living with HIV (PLWH) and people without HIV. In this systematic review and meta-analysis, PubMed/MEDLINE, Embase, and Google Scholar were searched up to March 7, 2023. A random effects model was used to calculate the pooled prevalence along with the 95% confidence intervals (CI), and the odds ratio and its corresponding 95% CIs were calculated to elucidate the significance of each clinical feature for mpox patients with and without HIV. In this study, we included 99 published papers with 2413 patients with mpox (median age, 35.5 years; PLWH n = 1151) from 27 countries across six continents. The odds ratio of the mpox outcomes with PLWH in

Comparison of clinical course of Mpox among HIV‐negative and HIV‐positive patients: A 2022 cohort of hospitalized patients in Central Europe

“…In our study the percentage of patients coinfected with HIV was compared to other cohorts and amounted to 45.7% 11–13 . Higher prevalence of rectal signs and symptoms among PWH is now reported in the literature 14,18,30,33 . This phenomenon did not vary by HIV immune status and most likely explanation is related to the exposure site.…”

Transmission dynamics, complications and mitigation strategies of the current mpox outbreak: A comprehensive review with bibliometric study

“…Global mpox outbreak has shed light on sexual activity and mpox transmission being strongly associated 11 . A link between specific sexual practices and lesions location, with frequently risky sexual behaviours was evident in mpox cases 11,89,90 . Further, MPXV isolated from infectious sexual fluids and anogenital lesions were often observed before the obvious symptoms appear, supporting the theory of direct inoculation during active sex.…”

“…88 The risk of severe mpox among the subjects living with HIV patients was ever higher as compared to the ones without HIV. 89 Clinical manifestations of mpox in the subjects with and without HIV in 99 studies covering 2413 patients from 27 countries were meta-analysed, and it was found that skin rash, proctitis, cough and diarrhoea differently manifested between the groups. Secondary infections in smallpox unvaccinated MPXV contacts increased by 10% with 1%-11% CFR.…”

“…Secondary infections in smallpox unvaccinated MPXV contacts increased by 10% with 1%-11% CFR. 89 STDs (like syphilis) co-infection created mucosal lesions that encouraged mpox transmission. 90 Mpox genital ulcers might increase the susceptibility to HIV.…”

“…A systematic review and meta‐analysis reported high global prevalence of HIV among mpox patients 88 . The risk of severe mpox among the subjects living with HIV patients was ever higher as compared to the ones without HIV 89 . Clinical manifestations of mpox in the subjects with and without HIV in 99 studies covering 2413 patients from 27 countries were meta‐analysed, and it was found that skin rash, proctitis, cough and diarrhoea differently manifested between the groups.…”