Comparison of clinical features in HLA‐B27 positive and negative patients with ankylosing spondylitis

Abstract

The clinical features of ankylosing spondylitis ( A S ) were compared in 63 HLA-B 27 positive ( + ) and 15 B27 negative ( -) individuals with this disease. There were no differences in age at onset, functional class, degree of deformity, pain, severity of X-ray changes, or frequency of peripheral joint involvement or of reconstructive orthopedic surgery. These data demonstrated that skeletal manifestations of AS were essentially the same in B27( +) and ( -) patients, and provide no evidence for the speculation that AS in B27( -) patients is milder or is a different disease from that occurring in B27(+) patients. On the other hand, acute anterior uveitis was found to be significantly more common in B27( +) patients, a fact suggesting that the "uveitis of AS" may in fact be an independent condition occurring in B27( +) individuals, rather than a manifestation of A S per se.The association between ankylosing spondylitis (AS) and the presence of HLA-B27 is remarkably strong

Low frequency of HLA-B27 in ankylosing spondylitis and its relationship with clinical findings in patients from Turkey

“…Some recent clinical studies proved the relationship between HLA-B27 positivity and the early onset of symptoms; however, some studies reported a negative relationship (11,12). In the present study, there was no significant relationship between the age of disease onset and HLA-B27 positivity.…”

Ankylosing Spondylitis Patients with HLA-B*2704 have More Uveitis than Patients with HLA-B*2705 in a North Chinese Population

“…In this study, HLA-B*2704 and HLA-B*2705 were the most prevalent HLA-B27 subtypes detected in the north Chinese AS patients, and this finding is consistent with findings of previous studies on Chinese patients with AS. 5,8,11 It has been reported that HLA-B*2704-positive patients had a significantly earlier onset of disease than that of HLA-B*2705-positive patients 10 but we did not find this difference in our study. Neither were there differences in disease activity between AS patients with B*2704 and B*2705.…”

“…9 It was also reported that HLA-B27-positive AS patients are more likely to develop acute anterior uveitis than HLA-B27-negative ones as early as in 1977. 10 For the subtypes of HLA-B27, most subtypes are too rare to make any substantial statement about disease association, but the common subtypes of HLA-B27, B2702, B2704, and B2705 have all been AS Patients with B*2704 have More Uveitis than B*2705 67 associated with AS in previous studies. In this study, HLA-B*2704 and HLA-B*2705 were the most prevalent HLA-B27 subtypes detected in the north Chinese AS patients, and this finding is consistent with findings of previous studies on Chinese patients with AS.…”

High prevalence of hla‐cw1 and cw2 antigens in spondylarthritis

“…However, patients with both antigens appeared to have extraarticular stigmata more frequently than the other groups, while patients with B27 seemed to develop more severe sacroiliitis radiographically. These findings must be interpreted with caution because of the small numbers within each group and because others have found no clinical or radiographic differences in B27-positive versus B27-negative patients with ankylosing spondylitis (31 ).…”