Comparison of clinical diagnoses and autopsy findings in 54 cases with lymphoid neoplasms

Abraham, L.; Kreipe, Hans; Hussein, Kais

doi:10.1007/s12308-019-00357-9

Cited by 2 publications

(8 citation statements)

References 21 publications

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“…The risk of developing a PTLD or post-transplant solid tumours is approximately 1%–5% in the first 5–10 years after transplantation 5 30–34. Due to modern diagnostic tools, a low discovery rate of previously unknown solid tumours at autopsy of <5% is to be expected 24 35. In our cohort of transplant patients, the frequency of incidentally identified PTLD and solid tumours was <5% for each.…”

Section: Discussionmentioning

confidence: 72%

“…Death is a multifactorial process and we aimed to classify the causes of death according to the most severely damaged organ system, sepsis or haemorrhage/non-cardiac infarctions 24. ‘Sepsis’ is a relatively common suspected clinical cause of death.…”

Section: Discussionmentioning

confidence: 99%

“…Exclusion criteria were haematopoietic stem cell transplantation and implantation of an artificial heart device. Note that 10 cases were included in a previous analysis, which encompassed the same time interval but focused on lymphoid neoplasms 24…”

Section: Methodsmentioning

confidence: 99%

“…Autopsies were performed in a standardised fashion and included cranial, thoracic and abdominal preparations and macroscopic inspection 24. In all cases, heart, lungs, liver, spleen, gastrointestinal tract, kidneys and vertebral bone marrow were histologically evaluated (minimum of 15 tissue samples).…”

Section: Methodsmentioning

confidence: 99%

“…If more than one organ system was diseased, the most severe pathological condition was classified as the leading cause of death. This included brain damage, failure of donor or recipient heart, lungs, liver or kidneys, sepsis (defined as histologic septicopyaemic lesions) or haemorrhage/non-cardiac infarction 24. The occurrence of transplant rejection or tumour infiltration was correlated with the cause of death.…”

Section: Methodsmentioning

confidence: 99%

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Clinically latent and autopsy-verified inflammatory disorders and malignant tumours in transplant patients

et al. 2020

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AimsThe number of clinical autopsies decreases while the rate of missed relevant diagnoses is known to be 2%–20%. In this study, we focused on postmortem examinations of patients after transplantation of solid organs.MethodsA total of 122 cases were assessed for this study. Transplant organs included liver (LiTx; n=42/122, 34%), heart (n=8/122, 7%), lungs (n=32/122, 26%), kidney (KTx; n=38/122, 31%) and KTx+LiTx (n=2/122, 2%).ResultsThe most frequent autopsy-verified causes of death were cardiac or respiratory failure (together n=85/122, 70%). The frequency of malignant tumours that were identified at autopsy was 5% (n=6/122). In 3% (n=4/122) of cases, Goldman class I discrepancies between clinical diagnosis and autopsy findings were identified.ConclusionsThe rate of missed relevant diagnoses might be relatively low, but these cases nevertheless refute the contention that modern diagnostic techniques negate the need for autopsies in patients who died after transplantation.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Clinically latent and autopsy-verified inflammatory disorders and malignant tumours in transplant patients

et al. 2020

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Minimally invasive autopsy – endoscopic approach to post-mortem diagnostics

Świderski,

Rzepczyk,

Bożek

et al. 2023

Videosurgery and Other Miniinvasive Techniques

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The noticeable decline in the number of autopsies performed in recent years requires investigation into the causes of the phenomenon and attempts to prevent it. One potential cause of this trend is fear of disfiguring the body. Carrying out autopsies using a minimally invasive method may reduce the decrease in the number of autopsies performed. The first work on the development of the method and its continuation gave promising results. This allows us to start a discussion on attempts to introduce the method. The solution seems especially justified when the alternative is to completely abandon post-mortem examinations using the traditional method. Laparoscopy and thoracoscopy are tools that allow for accurate imaging and analysis of organ changes. Enriching them with additional tests using endoscopic techniques may have a positive impact on the accuracy of autopsy diagnoses. The development of a clear protocol for minimally invasive post-mortem diagnosis requires further research to determine the accuracy of the method.

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Comparison of clinical diagnoses and autopsy findings in 54 cases with lymphoid neoplasms

Cited by 2 publications

References 21 publications

Clinically latent and autopsy-verified inflammatory disorders and malignant tumours in transplant patients

Clinically latent and autopsy-verified inflammatory disorders and malignant tumours in transplant patients

Minimally invasive autopsy – endoscopic approach to post-mortem diagnostics

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