Comparison of Clinical Associations and Laboratory Abnormalities in Children With Moderate and Severe Dehydration

Hayajneh, Wail A.; Jdaitawi, Hussein; Shurman, Abdullah; Hayajneh, Yaseen A

doi:10.1097/mpg.0b013e31819de85d

Cited by 29 publications

(26 citation statements)

References 21 publications

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“…None should be used for indiscriminate treatment by the numbers (5,16). Complementary use of the empirical equations and userfriendly graphics may, however, aid in discerning the quantity and quality of body water losses and thus better inform (16) the heuristic treatment (5,8,(11)(12)(13)(14) of dehydration. Finally, we recognize the possible confusion of strictly misinterpreting 1-p (23,24), but consider that this approach provides benefit if the result is a clinical tool which can be more easily understood (26,27) and applied (1,22,25).…”

Section: Discussionmentioning

confidence: 99%

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Reference change values for monitoring dehydration

Cheuvront

Fraser²,

Kenefick³

et al. 2011

Clinical Chemistry and Laboratory Medicine

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Section: Discussionmentioning

confidence: 99%

“…Diagnosis and management often require heuristic evaluation and treatment decisions can have important medical implications (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Recent research (1) described the biological variation and diagnostic threshold values for several common markers of dehydration.…”

Section: Introductionmentioning

confidence: 99%

Reference change values for monitoring dehydration

Cheuvront

Fraser²,

Kenefick³

et al. 2011

Clinical Chemistry and Laboratory Medicine

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show abstract

“…An elevated blood urea or urea nitrogen, creatinin, base excess, uric acid, serum anion gap and urine-specific gravity as well as decreased pH and bicarbonate concentration have been associated, albeit not pathognomonically, with severe dehydration [45][46][47][48]. Despite the efforts of different research groups, there is no exclusive laboratory test, nor accurate cut-off values that can be used as a sole marker of severe dehydration [14].…”

Section: Rationale For a Diagnostic Work-upmentioning

confidence: 99%

An update on management of severe acute infectious gastroenteritis in children

O’Ryan

Lucero

O'Ryan-Soriano

et al. 2010

Expert Review of Anti-infective Therapy

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This article focuses on clinical and diagnostic aspects relevant to severe acute infectious gastroenteritis in children and will update treatment strategies focused on, although not limited to, anti-infective therapy. For the purposes of this article we will consider severe acute infectious gastroenteritis as follows: watery diarrhea accompanied by, or at high risk for, moderate to severe dehydration due to abrupt onset of vomiting that reduces oral intake, and/or frequent emission of liquid stools, or moderate to severe dysenteric/bloody diarrhea with moderate to high-grade fever. The article will not include food poisoning associated with bacterial toxins and will only briefly discuss oral rehydration strategies and intravenous solutions. The article will also briefly discuss current preventive measures against rotavirus gastroenteritis through vaccination, a topic that has been extensively discussed elsewhere.

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“…Hayajneh WA et al (9) found that serum urea, creatinine, sodium, potassium, and glucose were useful independently in children presenting with gastroenteritis, and serum urea was found to be the best among all. King et al (7) indicated that serum electrolytes assessment is not necessary for acute diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Abnormal Laboratory Tests in Patients with Dehydration Due to Gastroenteritis: A Medical Audit Study

et al. 2016

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Background: Gastroenteritis is one of the major causes of morbidity and mortality among children, and it accounts for 18% of childhood death. Conducting laboratory tests is challenging for these patients, and the validity of the laboratory studies in treatment and prognosis is in question. Objectives: This study aimed to investigate the necessity of performing laboratory tests, and intended to reduce hospitalization costs. Methods: Patients with moderate to severe dehydration due to gastroenteritis, who referred to the emergency ward of Amir Kabir hospital from April to August 2008, were enrolled in this cross-sectional descriptive study. The routine lab tests, including complete blood cell, urine analysis, stool exam and electrolytes were performed, and statistical analysis was done by SPSS software. Results: Of the 610 patients, 0.3% had severe, 99.7% had moderate dehydration, and 42.78% were female. The lab results of the patients revealed the following information: Blood sugar: 97.3%; sodium: 95.5%; potassium: 93.5%; blood creatinine: 95.4%; blood urea nitro: 87.9%; urine analysis: 90.7%; urine culture: 96.8%; stool exam: 83.3%; white blood cell count: 87.7%. However, hemoglobin was found to be 77.4%, which was normal. Conclusions: It is reasonable to evaluate blood urea nitrogen, potassium, and hemoglobin of children with gastroenteritis. Moreover, conducting white blood cell, stool exam, and urine analysis is recommended for those with febrile gastroenteritis, especially in girls younger than two years of age. Overall, conducting all the mentioned tests for these patients is not necessary as a routine, and decision should be made based on the clinical condition of the patients and their doctors' opinion.

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Comparison of Clinical Associations and Laboratory Abnormalities in Children With Moderate and Severe Dehydration

Cited by 29 publications

References 21 publications

Reference change values for monitoring dehydration

Reference change values for monitoring dehydration

An update on management of severe acute infectious gastroenteritis in children

Distribution of Abnormal Laboratory Tests in Patients with Dehydration Due to Gastroenteritis: A Medical Audit Study

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