Comparison of clinical and sewage isolates of Acinetobacter baumannii from two long-term care facilities in Zagreb; mechanisms and routes of spread

Bedenić, Branka; Siroglavić, Marko; Slade, Mia; Šijak, Dorotea; Dekić, Svjetlana; Musić, Martina Šeruga; Godan-Hauptman, Ana; Hrenović, Jasna

doi:10.1007/s00203-019-01750-9

Cited by 6 publications

(3 citation statements)

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“…This finding poses a serious challenge for clinicians working in COVID units because the new antibiotics such as ceftazidime/avibactam, ceftolozane/tazobactam and imipenem/relebactam have no activity on CRAB. The resistance determinants found in this study are in line with previously published results from the same geographic area, indicating that OXA-24-like and OXA-23-like are endemic among A. baumannii in Zagreb hospitals and in nursing homes also [48][49][50][51]. Recently pandrug-resistant A. baumannii isolates harbouring OXA-23 and colistin-resistant determinants were described in a hospital centre in eastern region of Croatia [52], but in the current study all isolates were susceptible to colistin, in spite of the fact that colistin is often used to treat BSI in COVID centers.…”

Section: Discussionsupporting

confidence: 92%

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Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb

et al. 2023

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During November to December 2020, a high rate of COVID-19-associated pneumonia with bacterial superinfections due to multidrug-resistant (MDR) pathogens was recorded in a COVID-19 hospital in Zagreb. This study analyzed the causative agents of bacterial superinfections among patients with serious forms of COVID-19. In total, 118 patients were hospitalized in the intensive care unit (ICU) of the COVID-19 hospital. Forty-six out of 118 patients (39%) developed serious bacterial infection (VAP or BSI or both) during their stay in ICU. The total mortality rate was 83/118 (70%). The mortality rate due to bacterial infection or a combination of ARDS with bacterial superinfection was 33% (40/118). Six patients had MDR organisms and 34 had XDR (extensively drug-resistant). The dominant species was Acinetobacter baumannii with all isolates (34) being carbapenem-resistant (CRAB) and positive for carbapenem-hydrolyzing oxacillinases (CHDL). One Escherichia coli causing pneumonia harboured the blaCTX-M-15 gene. It appears that the dominant resistance determinants of causative agents depend on the local epidemiology in the particular COVID center. Acinetobacter baumannii seems to easily spread in overcrowded ICUs. Croatia belongs to the 15 countries in the world with the highest mortality rate among COVID-19 patients, which could be in part attributable to the high prevalence of bacterial infections in local ICUs.

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Section: Discussionsupporting

confidence: 92%

“…Colistin resistance in Croatian A. baumannii isolates was previously reported to be related to single nucleotide polymorphism in pmr B and mgr B genes [ 52 ]. ST195 was previously identified in A. baumannii in Croatia in both clinical and environmental isolates [ 50 , 51 ]. STs 478 and 748 were reported for the first time in Croatia.…”

Section: Discussionmentioning

confidence: 99%

Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb

et al. 2023

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“…Esse microrganismo pode se espalhar pelo ar, gotículas de água em curtas distâncias, a pele descascada de pacientes colonizados e as mãos dos trabalhadores do hospital. 3,4 Tambem pode ser encontrado na garganta e no nariz de pessoas saudáveis. 19 Essas cepas bacterianas podem persistir por longos períodos em superfícies úmidas e secas, pois possuem requisitos nutricionais mínimos, são tolerantes a várias condições físicas, como umidade e temperatura.…”

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Acinetobacter baumannii isolados em amostras de pacientes pediátricos internados em um hospital especializado em doenças infectocontagiosas / Acinetobacter baumannii isolated from samples of pediatric patients admitted to a hospital specializing in infectious diseases

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Souza

et al. 2020

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Justificativa: O Acinetobacter baumannii tem acometido pacientes imunossuprimidos e pediátricos e está associado a surtos de infecções nosocomiais/hospitalares e por esse motivo deve haver investigação constante e por tais razões o objetivo deste é mostrar os resultados retrospectivos da ocorrência desse patógeno isolados em culturas de pacientes internados em um hospital especializado em doenças infectocontagiosas. Metodologia: pesquisa retrospectiva, descritiva, realizada a partir da coleta de dados de variáveis existentes nas planilhas de notificação de infecção relacionadas a assistência à saúde-IRAS existentes no banco de dados da Comissão de Controle de Infecção Hospitalar-CCIH de um hospital referência em infectologia no Amazonas. Resultados: foram notificadas, por meio de culturas e antibiogramas, 4 casos de infecções nosocomial/hospitalar relacionadas a assistência a saude por Acinetobacter baumannii em pacientes internados nas enfermarias e UTI´s da referida instituição de saude destas, 75% eram de pacientes do gênero masculino sendo 3 pediátrico, e 75% eram infecções do trato respiratório em pacientes sob ventilação mecânica e 25% infecções primarias da corrente sanguínea. Tambem evidenciou-se que 26% eram cepas com alta resistência aos beta-lactamases (enzima produzida por bactérias que podem inibir a ação das penicilinas). Conclusão: Sabendo-se que o Acinetobacter baurmanii tem ganhado resistencia, vê-se como forma mais eficaz de quebra de cadeia de transmissão, ainda, a prevenção por meio da adesão a higienização das mãos.

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