Comparison of clinical and morphological characteristics of Staphylococcus aureus endocarditis with endocarditis caused by other pathogens

Nadji, Georges; Rémadi, Jean-Paul; Coviaux, F.; Mirode, A; Brahim, Amel; Enriquez-Sarano, M.; Tribouilloy, Christophe

doi:10.1136/hrt.2004.042648

Cited by 76 publications

(55 citation statements)

References 41 publications

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“…S. aureus is the most common pathogen in these patients. 18,21, 22 It is associated with high morbidity and mortality compared with IE caused by other pathogens. 7,18,23, 24 In the present report, 10 out of 14 patients with i.v.…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment for Isolated Tricuspid Valve Endocarditis

Baraki

Saito

Ahmad

et al. 2013

Circ J

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment for Isolated Tricuspid Valve Endocarditis

Baraki

Saito

Ahmad

et al. 2013

Circ J

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“…Patient characteristics associated with S. aureus IE include injection drug use, health care-associated infections, a shorter duration of symptoms prior to diagnosis, persistent bacteremia, the presence of a presumed intravascular device source, stroke, and diabetes mellitus (125,171). Table 3 outlines the major demographic and clinical features of S. aureus IE.…”

Section: Clinical Manifestations and Outcomesmentioning

confidence: 99%

“…The clinical manifestations of S. aureus IE are now well understood through the ICE-PCS cohort (125) as well as national cohorts (170) and long-term single-center studies (146,171,172). Patient characteristics associated with S. aureus IE include injection drug use, health care-associated infections, a shorter duration of symptoms prior to diagnosis, persistent bacteremia, the presence of a presumed intravascular device source, stroke, and diabetes mellitus (125,171).…”

Section: Clinical Manifestations and Outcomesmentioning

confidence: 99%

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

et al. 2015

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SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

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“…1,2,5,6 Nadji et al compared S. aureus IE with that caused by other pathogens, and found that the 36-month actual overall survival rate was significantly lower for S. aureus IE than IE caused by other pathogens. 2 This poor prognosis is because S. aureus is frequently resistant to antibiotics, and induces severe inflammation and systemic emboli in the early phase of sickness. Among cases of S. aureus IE, mortality is higher for MRSA than for MSSA, and for those with prosthetic valves than in cases involving native valves (range 25-59%).…”

Section: Discussionmentioning

confidence: 99%

“…1 Although diagnostic and therapeutic methods have improved and developed, the mortality rate for S. aureus IE is still higher than that caused by other pathogens. 2 In addition, the prevalence of S. aureus IE is also becoming higher in Japan, 3,4 concurrent with an increase in predisposing factors such as use of intravascular devices and intravenous drugs. 1 Here we report recent 3 cases of S. aureus IE that had a rapidly progressive fatal clinical course despite intensive antimicrobial therapy.…”

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confidence: 99%

Three Fatal Cases of Rapidly Progressive Infective Endocarditis Caused by Staphylococcus Aureus One Case With Huge Vegetation

Miyata

Satoh

Inokuchi³

et al. 2007

Circ J

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nfective endocarditis (IE) caused by Staphylococcus aureus (S. aureus) is a serious septic disease that can be fatal unless effective therapy under correct diagnosis is initiated as soon as possible. 1 Although diagnostic and therapeutic methods have improved and developed, the mortality rate for S. aureus IE is still higher than that caused by other pathogens. 2 In addition, the prevalence of S. aureus IE is also becoming higher in Japan, 3,4 concurrent with an increase in predisposing factors such as use of intravascular devices and intravenous drugs. 1 Here we report recent 3 cases of S. aureus IE that had a rapidly progressive fatal clinical course despite intensive antimicrobial therapy. One patient had a prosthetic mitral valve, which was infected with methicillin-sensitive S. aureus (MSSA), and the other 2 patients were infected with methicillin-resistant S. aureus (MRSA) on native valves. We review these cases and discuss the management of S. aureus IE in relation to current studies. Case Reports Case 1A 64-year-old man, who had undergone replacement of a mechanical mitral valve 12 years ago in the USA, felt a general malaise and developed a high fever (>38°C) 3 days prior to admission to a community hospital where he was treated with intravenous flomoxef (2 g/day) followed by ampicillin (4 g/day). Transthoracic echocardiography on the second day revealed no definite vegetation or valve dysfunction. The high fever continued and on the third day of the clinical course, Osler's nodes appeared. He was thus strongly suspected of having IE and was transferred to the Cardiology Department for further examination and treatment. On admission, the patient was alert, with a temperature of 40.6°C, blood pressure of 120/60 mmHg, and pulse rate of 120 beats/min (irregular). Auscultation of the chest showed a grade II/VI holo-systolic murmur that was maximal at the cardiac apex and there were normal vesicular respiratory sounds without rales. The chest X-ray revealed cardiomegaly (cardiothoracic ratio 66%) without lung congestion. Electrocardiography (ECG) showed atrial fibrillation with tachycardia. Major blood chemistry findings were: hemoglobin 13.3 g/dl, white blood cell 13,000 /mm 3 , platelets 48,000 /mm 3 , C-reactive protein (CRP) 16.11 mg/dl, INR 2.38, albumin 2.9 g/dl, total bilirubin 1.1 mg/dl, LDH 467 U/L, BUN 13 mg/dl, creatinine 0.9 mg/dl, Na 132 mmol/L, K 3.9 mmol/L, and brain natriuretic peptide 230 pg/ml. Transthoracic and transesophageal echocardiography revealed a vegetation of 10 mm in length on the prosthetic mitral valve, with a mild perivalvular leak. The diagnosis of IE was made. Relatively deep wounds in both hands because of enthusiastic golf practice a few months before the onset of the sickness were suggestive as the portal of entry of the microorganism. Because the antibiotics he had been administered at the previous hospital had been ineffective, we scheduled blood culture for the following day under antibiotic-free conditions and planned to start antibiotic treatment thereafter. That nig...

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Comparison of clinical and morphological characteristics of Staphylococcus aureus endocarditis with endocarditis caused by other pathogens

Cited by 76 publications

References 41 publications

Surgical Treatment for Isolated Tricuspid Valve Endocarditis

Surgical Treatment for Isolated Tricuspid Valve Endocarditis

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Three Fatal Cases of Rapidly Progressive Infective Endocarditis Caused by Staphylococcus Aureus One Case With Huge Vegetation

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