Comparison of clinical and functional outcome between surgical treatment and carbon ion radiotherapy for pelvic chondrosarcoma

Outani, Hidetatsu; Hamada, Kenichiro; Imura, Yoshinori; Oshima, Kazuya; Sotobori, Tsukasa; Demizu, Yusuke; Kakunaga, Shigeki; Joyama, Susumu; Imai, Reiko; Okimoto, Tomoaki; Naka, Norifumi; Kudawara, Ikuo; Ueda, Takafumi; Araki, Nobuhito; Kamada, Tadashi; Yoshikawa, Hideki

doi:10.1007/s10147-015-0870-z

Cited by 36 publications

(43 citation statements)

References 24 publications

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“…It can help clinicians better stratify patients preoperatively for accurate personalized treatment in clinical practice. For these patients with high risk of recurrence, more aggressive regimens can be developed, or in combination with some new radiotherapy and chemotherapy, such as carbon ion radiotherapy . In the clinical radiomics nomogram based on DWI features, the proportion of clinical data increased.…”

Section: Discussionmentioning

confidence: 99%

“…For these patients with high risk of recurrence, more aggressive regimens can be developed, or in combination with some new radiotherapy and chemotherapy, such as carbon ion radiotherapy. 1 In the clinical radiomics nomogram based on DWI features, the proportion of clinical data increased. This indicates that clinical data plays a more important role in the single-sequence DWI model.…”

Section: Discussionmentioning

confidence: 99%

“…CS mostly affects people in their 40s to 70s . Wide local excision has become the mainstay treatment because this tumor is highly resistant to chemotherapy and radiation . The recurrence rates of pelvic CS range from 17–32% and is associated with poor survival …”

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confidence: 99%

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Can clinical radiomics nomogram based on 3D multiparametric MRI features and clinical characteristics estimate early recurrence of pelvic chondrosarcoma?

Yin

Mao

Liu

et al. 2019

Magnetic Resonance Imaging

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Background Chondrosarcoma (CS) is the second most common primary malignant bone tumor, with a relatively high recurrence rate. However, an effective method that estimates whether pelvic CS will recur after surgery, which influences the formulation of a clinical treatment plan, remains lacking. Purpose To develop and validate a clinical radiomics nomograms based on 3D multiparametric magnetic resonance imaging (mpMRI) features and clinical characteristics that could estimate early recurrence (ER) (≤1 year) of pelvic CS. Study Type Retrospective. Population In all, 103 patients (ER = 41, non‐ER = 62) with histologically proven CS were retrospectively analyzed and divided into a training set (n = 72) and a validation set (n = 31). Field Strength/Sequence 3.0T axial T1‐weighted (T1‐w), T2‐weighted (T2‐w), diffusion weighted imaging (DWI), contrast‐enhanced T1‐weighted (CET1‐w). Assessment Risk factors (sex, age, type, grade, resection margins, etc.) associated with ER were evaluated. Five individual models based on T1‐w, T2‐w, DWI, CET1‐w, and clinical data were built. Then we compared the performance of models based on T1‐w, T2‐w, CET1‐w and their combination. Lastly, two nomograms based on the best model + clinical data and DWI + clinical data were built. Statistical Tests The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) were used to evaluate different models. Results Grade was the most important univariate clinical predictor of ER of pelvic CS patients (odds ratio [OR]1 = 4.616, OR2 = 8.939, P < 0.05). T1‐w + T2‐w + CET1‐w had a significantly higher performance than CET1‐w in the training set (P = 0.01). Radiomics features are more important than clinical characteristics in clinical radiomics nomograms, especially for multisequence combined features (OR = 3.208, P < 0.01). Clinical radiomics nomogram based on combined features (T1‐w + T2‐w + CET1‐w) + clinical data achieved an AUC of 0.891 and ACC of 0.857, followed by DWI + clinical data (AUC = 0.882, ACC = 0.760) in the validation set. Data Conclusion The clinical radiomics nomogram had good performance in estimating ER of pelvic CS patients, which would be helpful in clinical decision‐making. Level of Evidence: 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:435–445.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Can clinical radiomics nomogram based on 3D multiparametric MRI features and clinical characteristics estimate early recurrence of pelvic chondrosarcoma?

Yin

Mao

Liu

et al. 2019

Magnetic Resonance Imaging

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“…For unresectable non-skull base chondrosarcomas, the NIRS experience of 75 patients with CIRT demonstrated 55% and 57% 5-year local control and overall survival, with four patients reported as having experienced grade 3 or 4 skin/soft tissue late adverse effects [115]. A small retrospective study comparing surgery vs. CIRT for pelvic chondrosarcomas showed similar survival but improved functional outcomes with CIRT [116]. At least one case report has shown the successful treatment of primary cardiac angiosarcoma in a young female [117].…”

Section: Clinical Experiences With Cirtmentioning

confidence: 99%

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Mohamad

Sishc

Saha

et al. 2017

Cancers

142

130

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Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE). This enhanced RBE is driven by a unique DNA damage signature characterized by clustered lesions that overwhelm the DNA repair capacity of malignant cells. These physical and radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having the potential for simultaneously maximally sparing normal tissues. Thus, CIRT could potentially be used to treat some of the most difficult to treat tumors, including those that are hypoxic, radio-resistant, or deep-seated. Clinical data, mostly from Japan and Germany, are promising, with favorable oncologic outcomes and acceptable toxicity. In this manuscript, we review the physical and biological rationales for CIRT, with an emphasis on DNA damage and repair, as well as providing a comprehensive overview of the translational and clinical data using CIRT.

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“…At present, surgical resection remains the primary treatment option for chondrosarcoma (2). Due to its poor response to conventional chemotherapy and radiation therapy, chondrosarcoma is challenging to manage (3).…”

Section: Introductionmentioning

confidence: 99%

Puerarin induces cell apoptosis in human chondrosarcoma cell line SW1353 via inhibition of the PI3K/Akt signaling pathway

Huang

Cao

et al. 2017

Oncol Lett

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Abstract. Chondrosarcoma is a malignant soft tissue sarcoma with poor prognosis. Puerarin has been demonstrated to possess anticancer properties; however, the effects of puerarin in human chondrosarcoma cells remain unknown. The present study aimed to investigate the anticancer effects of puerarin in SW1353 human chondrosarcoma cells. SW1353 cells were treated with increasing concentrations of puerarin for different durations. Cell viability was evaluated using MTT assays. Cell apoptosis rates were determined by flow cytometry. The activities of caspase-3 and caspase-9 were measured by enzymatic assay. The expression of RAC-alpha serine/threonine-protein kinase (Akt), phosphorylated-Akt, caspase-3 and apoptosis-associated proteins, including B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) were detected by western blotting. Puerarin significantly decreased cell viability and significantly induced apoptosis of SW1353 cells. In addition, puerarin significantly increased the enzymatic activities of caspase-3 and caspase-9. Puerarin treatment suppressed the expression of p-Akt and Bcl-2 but promoted the expression of Bax and cleaved caspase-3 in SW1353 cells. Notably, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abrogated the decreased phosphorylation of Akt, suggesting that the PI3K/Akt signaling pathway is involved in mediating the anticancer effects of puerarin. The data from the present study indicated that puerarin exhibits anticancer effects in SW1353 cells and may be a potential therapeutic drug for patients with chondrosarcoma.

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Comparison of clinical and functional outcome between surgical treatment and carbon ion radiotherapy for pelvic chondrosarcoma

Abstract: Although more patients need to be monitored to assess the clinical and functional outcomes of CIRT for patients with chondrosarcoma of the pelvis, this treatment might offer an acceptable alternative.

Cited by 36 publications

References 24 publications

Can clinical radiomics nomogram based on 3D multiparametric MRI features and clinical characteristics estimate early recurrence of pelvic chondrosarcoma?

Can clinical radiomics nomogram based on 3D multiparametric MRI features and clinical characteristics estimate early recurrence of pelvic chondrosarcoma?

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Puerarin induces cell apoptosis in human chondrosarcoma cell line SW1353 via inhibition of the PI3K/Akt signaling pathway

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