Comparison of circulating dendritic cell and monocyte subsets at different stages of atherosclerosis: insights from optical coherence tomography

Zhuang, Jianhua; Han, Yang; Xu, Dachun; Zhu, Guofu; Singh, Shekhar; Chen, Luoman; Zhu, Meng-Yun; Chen, Wei; Xu, Yawei; Li, Xiankai

doi:10.1186/s12872-017-0702-3

Cited by 24 publications

(23 citation statements)

References 42 publications

(57 reference statements)

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“…In addition, intermediate monocytes of these patients expressed higher surface concentration of chemokine receptors, including CCR2, and of PRR, in particular TLR-4 [22]. Again, a study by Zhuang et al on 79 patients undergoing coronary angiography for acute coronary syndromes compared with 33 subjects with no evidence of coronary artery disease showed that the patients had higher circulating numbers of intermediate CD14 hi CD16 + monocytes [67]. In addition, patients with a thin cap fibroatheroma were shown to have the largest number of circulating CD14 hi CD16 + monocytes [67].…”

Section: Circulating Monocyte Subsets In Human Atherosclerosismentioning

confidence: 99%

“…Again, a study by Zhuang et al on 79 patients undergoing coronary angiography for acute coronary syndromes compared with 33 subjects with no evidence of coronary artery disease showed that the patients had higher circulating numbers of intermediate CD14 hi CD16 + monocytes [67]. In addition, patients with a thin cap fibroatheroma were shown to have the largest number of circulating CD14 hi CD16 + monocytes [67]. In a recent study by Ozaki et al on 65 subjects undergoing coronary multidetector computed tomography, the proportion of circulating CD14 hi CD16 + monocytes expressing TLR-4 was shown to be higher in subjects with plaque features of vulnerability [21].…”

Section: Circulating Monocyte Subsets In Human Atherosclerosismentioning

confidence: 99%

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The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis

Moroni

Ammirati

Norata

et al. 2019

Mediators of Inflammation

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Atherosclerosis is one of the leading causes of death and disability worldwide. It is a complex disease characterized by lipid accumulation within the arterial wall, inflammation, local neoangiogenesis, and apoptosis. Innate immune effectors, in particular monocytes and macrophages, play a pivotal role in atherosclerosis initiation and progression. Although most of available evidence on the role of monocytes and macrophages in atherosclerosis is derived from animal studies, a growing body of evidence elucidating the role of these mononuclear cell subtypes in human atherosclerosis is currently accumulating. A novel pathogenic role of monocytes and macrophages in terms of atherosclerosis initiation and progression, in particular concerning the role of these cell subsets in neovascularization, has been discovered. The aim of the present article is to review currently available evidence on the role of monocytes and macrophages in human atherosclerosis and in relation to plaque characteristics, such as plaque neoangiogenesis, and patients’ prognosis and their potential role as biomarkers.

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Section: Circulating Monocyte Subsets In Human Atherosclerosismentioning

confidence: 99%

Section: Circulating Monocyte Subsets In Human Atherosclerosismentioning

confidence: 99%

The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis

Moroni

Ammirati

Norata

et al. 2019

Mediators of Inflammation

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“…However, previous data regarding peripheral monocytes' prognostic value remains controversial. Several studies have demonstrated a significant association between monocyte subsets and atherosclerosis plaque severity, vulnerability, and progression of CVD 7,8,[14][15][16][17] . Additionally, CD14 CD16 monocytes were associated with restenosis, after percutaneous transluminal angioplasty, in individuals with peripheral artery disease 18) .…”

Section: Discussionmentioning

confidence: 99%

Relationship between Circulating Inflammatory Monocytes and Cardiovascular Disease Measures of Carotid Intimal Thickness

SahBandar

Ndhlovu

Saiki

et al. 2020

JAT

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The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Original Article Aims: Cardiovascular disease (CVD) remains the leading cause of death worldwide despite improvements in the treatment of atherosclerosis, an inflammatory disease and major underlying cause of CVD. Monocytes, an innate immune cell type, are linked to CVD progression; however, given their heterogeneity, the association between distinct monocyte subsets and increased risk of CVD remains unclear. This study investigated the association between peripheral monocyte subpopulation numbers and carotid intima-media thickness (cIMT), a sensitive measure of CVD risk, in a cohort of adults recruited from the general population. Methods: We used clinical data and peripheral blood mononuclear cell (PBMC) specimens from 67 individuals. cIMT was measured by high-resolution, B-mode, ultrasound images of the right carotid artery. PBMCs were stained with conjugated monoclonal antibodies to define monocyte subpopulations based on CD14 and CD16 co-expressions into classical (CD14 CD16), intermediate/inflammatory (CD14 CD16), and non-classical/ patrolling (CD14 low/ CD16) monocytes. Results: We found a higher intermediate monocyte count was significantly correlated with increased right common carotid artery (RCCA) and right carotid bifurcation (RBIF) intima-media thickness (IMT) (p 0.004 and 0.006, respectively), even after adjusting for CVD-associated clinical data (p 0.006 and 0.004, respectively). Conclusion: Our study demonstrated a strong correlation between inflammatory monocyte counts and cIMT. These results suggest that, in the general population, there is a relationship between intermediate monocyte expansion and elevated predictors for CVD risk, and intermediate monocytes may be involved in the development of atherosclerosis and metabolic diseases. Strategies targeting inflammatory monocytes may be needed to slow CVD progression. role in atherosclerotic plaque formation 1, 3). Based on CD14 and CD16 surface co-expression, monocytes are classified into three different subsets: classical (CD14 CD16), intermediate or inflammatory (CD14 CD16), and non-classical or patrolling (CD14 low/ CD16) 4). Existing studies have demonstrated monocytes' roles in various disorders, including those that are associated with CVD. Higher levels of classical monocytes have been correlated with insulin resistance, a metabolic disorder closely related to

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“…The decrease tended to be more pronounced in unstable coronary syndromes and extensive coronary artery disease, suggesting a possible role of pDCs as a prognostic tool in plaque progression and rupture (154). The percentage and absolute number of mDC2 were decreased in patients with atherosclerotic complications when compared with healthy controls, which implied that decreased circulating mDC2 could possibly serve as a marker of disease severity (155). Additionally, the absolute number of Lin1 − HLA-DR + peripheral-blood DCs and Lin1 − HLA-DR + CD11c + mDC, but not pDCs, were increased in patients with coronary artery disease (156).…”

Section: Markers and Tools In Atherosclerosis From Mouse And Humanmentioning

confidence: 94%

Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead

et al. 2020

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Atherosclerosis is a chronic process associated with arterial inflammation, the accumulation of lipids, plaque formation in vessel walls, and thrombosis with late mortal complications such as myocardial infarction and ischemic stroke. Immune and inflammatory responses have significant effects on every phase of atherosclerosis. Increasing evidence has shown that both innate and adaptive "arms" of the immune system play important roles in regulating the progression of atherosclerosis. Accumulating evidence suggests that a unique type of innate immune cell, termed dendritic cells (DCs), play an important role as central instigators, whereas adaptive immune cells, called T lymphocytes, are crucial as active executors of the DC immunity in atherogenesis. These two important immune cell types work in pairs to establish pro-atherogenic or atheroprotective immune responses in vascular tissues. Therefore, understanding the role of DCs and T cells in atherosclerosis is extremely important. Here, in this review, we will present a complete overview, based on existing knowledge of these two cell types in the atherosclerotic microenvironment, and discuss some of the novel means of targeting DCs and T cells as therapeutic tactics for the treatment of atherosclerosis.

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Comparison of circulating dendritic cell and monocyte subsets at different stages of atherosclerosis: insights from optical coherence tomography

Cited by 24 publications

References 42 publications

The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis

The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis

Relationship between Circulating Inflammatory Monocytes and Cardiovascular Disease Measures of Carotid Intimal Thickness

Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead

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