Comparison of Ciliary Body Anatomy between American Caucasians and Ethnic Chinese Using Ultrasound Biomicroscopy

He, Na; Wu, Lingling; Qi, Meng; He, Miao; Lin, Shan; Wang, Xin; Yang, Fan; Fan, Xiang

doi:10.3109/02713683.2015.1024869

Cited by 31 publications

(39 citation statements)

References 24 publications

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“…Our study showed that APAC eyes had thinner ciliary bodies and smaller anterior ciliary processes than in the fellow eyes.. He et al [ 9 ] demonstrated that Chinese persons have thinner ciliary bodies than American Caucasians and postulated that this may be associated with the higher prevalence of angle closure in the Chinese population. In addition, a quantitative study of the ciliary body in eyes with malignant glaucoma showed thinner ciliary body in eyes with malignant glaucoma and in their fellow eyes, which might indicate a predisposing factor for malignant glaucoma [ 14 ].…”

Section: Discussionsupporting

confidence: 51%

“…APAC was defined based on previous reported criteria: (1) the presence of at least two of the following symptoms: ocular pain, periocular pain or headache; (2) nausea and/or vomiting; (3) a previous history of intermittent blurred vision or halos around lights; (4) raised IOP of at least 25 mmHg; (5) and the presence of at least three of the following signs [ 7 ]: conjunctival injection, corneal epithelial oedema, mid-dilated unreactive pupil and/or a shallow anterior chamber. A primary angle closure suspect (PACS) eye was defined as a pigmented trabecular meshwork in the eye not visible or iridotrabecular contact (ITC) of 180 degrees or more under non-compressive gonioscopy (Goldmann), with normal IOP (<21 mmHg) and without peripheral anterior synechiae or glaucomatous neuropathy [ 2 , 8 , 9 ]. The choroidal thickness of all APAC eyes and their fellow PACS eyes were measured using SS-OCT. All imaging examinations were performed in 24 h right after the reduction of IOP by medication treatment (anti-inflammatory drops and/or a systemic steroid and hypertonic drugs) in affected eyes in order to ensure the corneal transparency, but before any procedures of peripheral iridectomy, iridoplasty or trabeculectomy.…”

Section: Methodsmentioning

confidence: 99%

“…AS-OCT imaging and image quantifications were conducted as described in our previous studies [ 2 , 9 , 11 ]. AS-OCT (Visante OCT; Carl Zeiss Meditec, Dublin, CA, USA) was measured under dark room conditions (0 lux) by a single-experienced operator who was masked to the diagnosis of the patients.…”

Section: Methodsmentioning

confidence: 99%

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Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes

Wang

Huang

et al. 2018

Eye

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PurposeTo measure the anterior and posterior ocular biometric characteristics concurrently and to explore the relationship between iris, ciliary body and choroid in acute primary angle closure eyes (APAC) and fellow eyes.MethodsIt is a prospective, cross-sectional study. Thirty patients with recent APAC were finally enroled in it. Anterior and posterior uveal parameters were measured simultaneously by anterior segment optical coherence tomography (AS-OCT), swept-source optical coherence tomography (SS-OCT) and ultrasound biomicroscopy (UBM). The parameters were measured including: pupil diameter (PD); iris thickness, curvature (ICURV), area (IAREA); anterior chamber depth (ACD), width (ACW), area (ACA), volume (ACV); lens vault (LV); choroidal thickness and retinal thickness; maximum ciliary body thickness (CBTmax); ciliary body thickness at the point of the scleral spur (CBT0) and 1000 mm away (CBT1000); anterior placement of the ciliary body (APCB); and trabecular-ciliary angle (TCA).ResultsCompared with fellow eyes, APAC eyes had narrower anterior biometric parameters and presented with smaller anterior segment parameters (including ACD and ACW); (p < 0.01)), smaller IAREA and ICURV (p < 0.001), larger LV (p = 0.035), thinner ciliary body and less anterior ciliary process (p < 0.01). After adjustment for potential confounders (axial length, spherical equivalent and PD), APCB was positive correlated with choroidal thickness and CBT, and CBT was positive correlated with choroidal thickness.ConclusionsCompared with fellow eyes, APAC eyes had narrower anterior biometric parameters, thinner ciliary body and smaller iris area and curvature. APCB, CBT and choroidal thickness were positively correlated. However, further studies are required before these conclusions are generalised.

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Section: Discussionsupporting

confidence: 51%

Section: Methodsmentioning

confidence: 99%

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Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes

Wang

Huang

et al. 2018

Eye

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“…It has been stated that the RLP can provide an idea as to the ciliary process location [30]. Our noncycloplegic RLP results indicated that the lens was 0.09 units more posterior in the KC group than in the control group.…”

Section: Discussionmentioning

confidence: 48%

Effect of Cycloplegia on Keratometric and Biometric Parameters in Keratoconus

Polat

Gündüz

2016

Journal of Ophthalmology

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Purpose. To obtain information about effect of cycloplegia on keratometry and biometry in keratoconus. Methods. 48 keratoconus (Group 1) and 52 healthy subjects (Group 2) were included in the study. We measured the flat meridian of the anterior corneal surface (K1), steep meridian of the anterior corneal surface (K2), lens thickness (LT), anterior chamber depth (ACD), and axial length (AL) using the Lenstar LS 900 before and after cycloplegia. Results. The median K1 in Group 1 was 45.64 D before and 45.42 D after cycloplegia, and the difference was statistically significant (P < 0.05). The median K2 in Group 1 was 50.96 D before and 50.17 D after cycloplegia, and the difference was significant (P < 0.05). The median K1 and K2 in Group 2 were 42.84 and 44.49 D, respectively, before cycloplegia, and 42.84 and 44.56 D after cycloplegia, and the differences were not statistically significant (all P > 0.05). There were significant differences in SE, LT, ACD, and RLP between before and after cycloplegia in either Group 1 (all P < 0.05) or Group 2 (all P < 0.05). There were not statistically significant differences in AL between before cycloplegia and after cycloplegia in either Group 1 (P = 0.533) or group 2 (P = 0.529). Conclusions. Flattened corneal curvature and increase in ACD following cycloplegia in keratoconus patients were detected.

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“…The characteristic boomerang-shaped iris in nanophthalmic eyes is thought to be an indirect indicator of anteriorly positioned ciliary processes. This physical displacement of the peripheral iris is associated with angle-narrowing and could result in goniosynechiae [ 26 ]. Hypertrophy of the ciliary body resulting from postoperative inflammation [ 25 ], annular ciliochoroidal effusion, or ciliary body detachment [ 27 ], and the relatively small space in the anterior segment in nanophthalmic eyes could result in the anterior positioning of the ciliary processes.…”

Section: Discussionmentioning

confidence: 99%

Morphological features of anterior segment: factors influencing intraocular pressure after cataract surgery in nanophthalmos

Lü

et al. 2020

Eye and Vis

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Purpose To investigate the anterior segment in nanophthalmic eyes and their association with intraocular pressure after cataract surgery. Methods Thirty-two nanophthalmic eyes (axial length [AL] < 18.5 mm) in 18 patients and 35 normal eyes (21 ≤ AL ≤ 24.5 mm) in 35 controls who had undergone uneventful cataract surgery were included. Swept-source optical coherence tomography was used to compare the anterior segment structures between the two groups. The associations between the anterior segment characteristics of nanophthalmic eyes and postoperative intraocular pressure (IOP) were also investigated. Results The IOP-lowering effect of cataract surgery was remarkably insufficient in nanophthalmic eyes. Peripheral anterior synechiae (PAS) were observed in 56% (18/32) of nanophthalmic eyes, and a characteristic boomerang-shaped iris was observed in 28% (9/32). The anterior surface of the iris seemed “smoother” in nanophthalmic eyes than in normal eyes. Schlemm’s canal (SC) diameter, SC area, trabecular meshwork (TM) thickness, TM width, and TM area were generally smaller in the nanophthalmic eyes. Younger age, higher preoperative IOP, broader PAS, and smaller SC area were main contributors to higher postoperative IOP. AL and SC diameter may also be of great importance in IOP prediction in patients without glaucoma surgery and PAS. Conclusions The morphological features of the anterior segment in nanophthalmic eyes are significantly different from those of normal eyes. Influencing factors such as age, AL, preoperative IOP, extent of PAS, SC and TM size could all be prognostic for IOP after cataract surgery in nanophthalmic eyes. Trial registration ClinicalTrails.gov, Trial registration number: NCT02182921, Registered 8 July 2014.

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Comparison of Ciliary Body Anatomy between American Caucasians and Ethnic Chinese Using Ultrasound Biomicroscopy

Abstract: Compared with the Caucasians, the Chinese had a thinner ciliary body and a more anteriorly positioned lens, which may contribute to more anteriorly positioned ciliary processes in this population. These findings might help to explain the higher prevalence of angle closure in the Chinese.

Cited by 31 publications

References 24 publications

Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes

Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes

Effect of Cycloplegia on Keratometric and Biometric Parameters in Keratoconus

Morphological features of anterior segment: factors influencing intraocular pressure after cataract surgery in nanophthalmos

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