Comparison of chitinase-3-like protein 1, aspartate aminotransferase-to-platelet ratio index, and fibrosis-4 index with shear-wave elastography

Mushtaq, Saadiya; Ghani, Eijaz; Azam, Khalid; Hussain, Tabinda

doi:10.1097/meg.0000000000001291

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…In our study, we did not find significant elevations of Bl (µmol/L), cholesterol (mmol/L), β-lipoproteins (g/L), AST (U/L), ALT (U/L) in all groups of patients. The use of indexes is a more convenient, cheap and non-invasive method to identify possible fibrotic changes, as also reported by other authors (10,(14)(15)(16)(17)(18) . Liver damage can significantly complicate JIA treatment with MTX; therefore, studies on non-invasive methods for the diagnosis and assessment of liver steatosis and fibrosis as prognostic factors seem to be promising.…”

Section: Discussionsupporting

confidence: 58%

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Fibrosis indexes in adolescents with juvenile idiopathic arthritis treated with methotrexate

Parkhomenko¹,

Strashok²,

Pavlov³

et al. 2021

Pediatr Med Rodz

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Juvenile idiopathic arthritis is the most common form of arthritis in children and adolescents. Methotrexate is the mainstay of juvenile idiopathic arthritis treatment. Methotrexate is well known to cause serum aminotransferase elevations, and longterm therapy has been linked to the development of fatty liver disease, fibrosis and even cirrhosis. The aim of the study was to assess non-invasive liver fibrosis indexes in adolescents with juvenile idiopathic arthritis treated with methotrexate. Materials and methods: A total of 68 children with juvenile idiopathic arthritis were enrolled in the study. A total of 68 children – 25 boys (36.8%) and 43 girls (63.2%) – were examined. The children were divided into four groups based on the methotrexate cumulative dose. The following data were analysed: total bilirubin and its fractions, cholesterol, β-lipoproteins, aspartate transaminase, alanine aminotransferase. Fibrosis indexes, i.e. APRI, FIB-4 score, AAR, AARPRI, were studied. Results: When studying the dynamics of non-invasive indices, their heterogeneous nature and cumulative dose dependence are determined. Statistically significant changes in fibrosis indexes and biochemical parameters were observed when the children reached cumulative methotrexate doses of 1 g and 3 g. Conclusions: It is possible to monitor carefully liver condition during the whole treatment and conduct a more in-depth examination only if it is necessary. Our data shows that the APRI index (AST to platelet ratio index) is most indicative.

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Section: Discussionsupporting

confidence: 58%

“…Liver fibrosis and steatosis indexes can be used to identify a group of children who need careful monitoring of the liver. However, the criteria for the appropriateness of using these indexes with JIA are still to be studied (14)(15)(16)(17)(18) . The use of fibrosis and steatosis indexes has been repeatedly studied.…”

Section: Introductionmentioning

confidence: 99%

Fibrosis indexes in adolescents with juvenile idiopathic arthritis treated with methotrexate

Parkhomenko¹,

Strashok²,

Pavlov³

et al. 2021

Pediatr Med Rodz

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“…Conversely, no relationship is found between CHI3L1 overexpression and survival in patients with cervical squamous cell carcinoma and liver cancer, while a negative correlation was observed between among patients bearing sarcoma. (from https://kmplot.com, http://www.cgga.org.cn) [177][178][179][180] Serum CHI3L1↑ → liver fibrosis Alcoholic liver disease 181,182 CHI3L1↑ → liver fibrosis Non-alcoholic fatty liver disease 183 CHI3L1↑ → liver fibrosis Bowel diseases IBD Fecal CHI3L1 → mucosal inflammation 184 and endoscopic activity 185 Colitis CHI3L1 binds to bacterial chitin-binding protein, 186,187 enhances bacterial adhesion and invasion, 60 activates Akt signaling 145 and IL-6-mediated STAT3 Phosphorylation 188 Cardiovascular Atherosclerosis CHI3L1↑ → coronary 189,190 and carotid 191 atherosclerosis severity↑, risk↑, 193 exacerbates atherosclerosis 192 Coronary artery disease Type 1 194 and type 2 195 diabetes CHI3L1↑…”

Section: Respiratory Diseases Inflammationmentioning

confidence: 99%

“… 176 For hepatitis B virus (HBV) infection, serum ChI3L1 level is a feasible biomarker to identify advanced liver fibrosis in patients with HBV-related liver fibrosis. 177 – 179 Moreover, CHI3L1 is regarded as a potential useful marker for monitoring the change of liver fibrosis in patients with chronic HBV infection during therapy. 180 For alcohol-induced fibrosis, increased serum CHI3L1 in patients with liver disease of various degree and etiology seems to reflect fibrosis and fibrogenesis.…”

Section: Chi3l1 In Digestive Diseasesmentioning

confidence: 99%

Chitinase-3 like-protein-1 function and its role in diseases

Zhao

et al. 2020

Sig Transduct Target Ther

290

265

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Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular matrix changes, cytokines, growth factors, drugs, and stress. CHI3L1 is synthesized and secreted by a multitude of cells including macrophages, neutrophils, synoviocytes, chondrocytes, fibroblast-like cells, smooth muscle cells, and tumor cells. It plays a major role in tissue injury, inflammation, tissue repair, and remodeling responses. CHI3L1 has been strongly associated with diseases including asthma, arthritis, sepsis, diabetes, liver fibrosis, and coronary artery disease. Moreover, following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line, CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models. To date, interleukin-13 receptor subunit alpha-2, transmembrane protein 219, galectin-3, chemo-attractant receptor-homologous 2, and CD44 have been identified as CHI3L1 receptors. CHI3L1 signaling plays a critical role in cancer cell growth, proliferation, invasion, metastasis, angiogenesis, activation of tumor-associated macrophages, and Th2 polarization of CD4+ T cells. Interestingly, CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.

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“…Until now, a series of clinical diagnostic techniques such as liver biopsy, B-mode ultrasonography, TE, and conventional serum markers (type III procollagen, type IV collagen, laminin, and hyaluronidase) have been devised for liver fibrosis diagnosis and assessment [ 65 , 66 ]. However, these methods have disadvantages that include invasiveness, high cost burden, and a lack of specificity.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A Meta-analysis

Huang

Zhuang

Yang

et al. 2022

BioMed Research International

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Background. Serum chitinase-3-like protein 1 (CHI3L1) is a promising marker for diagnosing liver fibrosis. This meta-analysis was carried out to assess the diagnostic performance of serum CHI3L1 for the estimation of liver fibrosis. Methods. Systematic searches were performed on PubMed, Embase, Web of Science, Scopus, the Cochrane Library, Google Scholar, Sinomed, the China National Knowledge Infrastructure (CNKI), the Chinese Medical Journal Database, and the Wanfang databases for available studies. The primary studies were screened strictly according to inclusion and exclusion criteria, and sensitivity, specificity, and other measures of accuracy of serum CHI3L1 for evaluating liver fibrosis were pooled with 95% confidence intervals. I 2 was calculated to assess heterogeneity, and sources of heterogeneity were explored by subgroup analysis. Deeks’ test was used to assess for publication bias, and likelihood ratio was used to determine posttest probability. Results. Our research integrated 11 articles, accounting for 1897 patients older than 18 years old. The pooled sensitivity and specificity for significant fibrosis, advanced fibrosis, and cirrhosis were 0.79 and 0.82 with an area under the receiver operating characteristic curve (AUC) of 0.85, 0.81 and 0.83 with an AUC of 0.91, and 0.72 and 0.74 with an AUC of 0.85, respectively. Random-effects models were used to assess for significant heterogeneity, and subgroup analysis showed that age and aetiology of included patients were likely sources of heterogeneity. No potential publication bias was found for serum CHI3L1 in the diagnosis of significant fibrosis, advanced fibrosis, or cirrhosis, and posttest probability was moderate. Conclusion. Measurement of serum CHI3L1 is a feasible diagnostic tool for liver fibrosis.

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Comparison of chitinase-3-like protein 1, aspartate aminotransferase-to-platelet ratio index, and fibrosis-4 index with shear-wave elastography

Cited by 7 publications

References 35 publications

Fibrosis indexes in adolescents with juvenile idiopathic arthritis treated with methotrexate

Fibrosis indexes in adolescents with juvenile idiopathic arthritis treated with methotrexate

Chitinase-3 like-protein-1 function and its role in diseases

Diagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A Meta-analysis

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