Comparison of Chi-Squared Automatic Interaction Detection Classification Trees vs TNM Classification for Patients With Head and Neck Squamous Cell Carcinoma

Avilés‐Jurado, Francesc Xavier; Terra, Ximena; E, Figuerola; Quer, Miquel; León, Xavier

doi:10.1001/archoto.2011.1448

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…Additionally, CHAID offers some analytical advantages compared with logistic regression. Whereas logistic regression identifies independent predictors, CHAID is adept at identifying interactions among the variables, including nonlinear relationships, and it can be used to identify subgroups in which covariates exert the greatest influence in a predictive model (25)(26)(27). Thus, CHAID can be used to generate or test hypotheses regarding the potential role of the relationship between variables Figure 3.…”

Section: Discussionmentioning

confidence: 99%

Association of Elevated Urinary Concentration of Renin-Angiotensin System Components and Severe AKI

Alge

Karakala

Neely

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground Prognostic biomarkers that predict the severity of AKI at an early time point are needed. Urinary angiotensinogen was recently identified as a prognostic AKI biomarker. The study hypothesis is that urinary renin could also predict AKI severity and that in combination angiotensinogen and renin would be a strong predictor of prognosis at the time of AKI diagnosis.Design, setting, participants, & measurements In this multicenter, retrospective cohort study, urine was obtained from 204 patients who developed AKI after cardiac surgery from August 2008 to June 1, 2012. All patients were classified as having Acute Kidney Injury Network (AKIN) stage 1 disease by serum creatinine criteria at the time of sample collection. Urine output was not used for staging. Urinary angiotensinogen and renin were measured, and the area under the receiver-operating characteristic curve (AUC) was used to test for prediction of progression to AKIN stage 3 or in-hospital 30-day mortality. These biomarkers were added stepwise to a clinical model, and improvement in prognostic predictive performance was evaluated by category free net reclassification improvement (cfNRI) and chi-squared automatic interaction detection (CHAID).Results Both the urinary angiotensinogen-to-creatinine ratio (uAnCR; AUC, 0.75; 95% confidence interval [CI], 0.65 to 0.85) and the urinary renin-to-creatinine ratio (uRenCR; AUC, 0.70; 95% CI, 0.57 to 0.83) predicted AKIN stage 3 or death. Addition of uAnCR to a clinical model substantially improved prediction of the outcome (AUC, 0.85; cfNRI, 0.673), augmenting sensitivity and specificity. Further addition of uRenCR increased the sensitivity of the model (cfNRI events , 0.44). CHAID produced a highly accurate model (AUC, 0.91) and identified the combination of uAnCR .337.89 ng/mg and uRenCR .893.41 pg/mg as the strongest predictors (positive predictive value, 80.4%; negative predictive value, 90.7%; accuracy, 90.2%). ConclusionThe combination of urinary angiotensinogen and renin predicts progression to very severe disease in patients with early AKI after cardiac surgery.

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Section: Discussionmentioning

confidence: 99%

Association of Elevated Urinary Concentration of Renin-Angiotensin System Components and Severe AKI

Alge

Karakala

Neely

et al. 2013

Clinical Journal of the American Society of Nephrology

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Comparison of prognostic implications between the 7th and 8th edition of AJCC TNM staging system for head and neck soft-tissue sarcoma in adult patients

Kim

Choi

Baek

et al. 2019

Eur Arch Otorhinolaryngol

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Employing biochemical biomarkers for building decision tree models to predict bipolar disorder from major depressive disorder

Zhu

et al. 2022

Journal of Affective Disorders

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Comparison of Chi-Squared Automatic Interaction Detection Classification Trees vs TNM Classification for Patients With Head and Neck Squamous Cell Carcinoma

Abstract: CHAID classification trees performed better than the TNM classification and offer potential inclusion of new prognostic factors.

Cited by 6 publications

References 24 publications

Association of Elevated Urinary Concentration of Renin-Angiotensin System Components and Severe AKI

Association of Elevated Urinary Concentration of Renin-Angiotensin System Components and Severe AKI

Comparison of prognostic implications between the 7th and 8th edition of AJCC TNM staging system for head and neck soft-tissue sarcoma in adult patients

Employing biochemical biomarkers for building decision tree models to predict bipolar disorder from major depressive disorder

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