Comparison of chest-CT findings of Influenza virus-associated pneumonia in immunocompetent vs. immunocompromised patients

Kloth, Christopher; Forler, Silvia Michaela Ute; Gatidis, Sergios; Beck, Robert; Spira, Daniel; Nikolaou, K; Horger, Marius

doi:10.1016/j.ejrad.2015.02.014

Cited by 15 publications

(8 citation statements)

References 19 publications

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“…The latter shows a thicker lobular septum in the lesions, and the air bronchogram sign in the consolidation shadow appears later. When the lesions demonstrate mixed GGO, COVID-19 has fewer solid areas and slightly lower density in the lesions, while influenza has more solid areas and higher density as reported previously (30).…”

Section: Identification Of Covid-19 and Influenza Pneumoniasupporting

confidence: 78%

Value Of High-Resolution Computed Tomography in the Differential Diagnosis of Imported COVID-19 and Seasonal Influenza Pneumonia: Differential Diagnosis of COVID-19 and Influenza Pneumonia using HRCT

2020

ircmj

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Background: Nowadays, the world is facing COVID-19 pandemic, and seasonal influenza is also sweeping the world. Therefore, it is essential to make an early differential diagnosis between imported COVID-19 and seasonal influenza pneumonia. Objectives: The present study aimed to determine the diagnostic value of high-resolution computed tomography (HRCT) imaging characteristics for imported coronavirus disease 2019 (COVID-19) and seasonal influenza pneumonia. Methods: The HRCT imaging features with 22 cases of imported COVID-19 and 39 cases of seasonal influenza pneumonia were retrospectively analyzed in the current study. The patients with COVID-19 or influenza were diagnosed according to the World Health Organization guidelines and were confirmed following positive reverse transcription-polymerase chain reaction(RT-PCR) analysis of respiratory secretion samples. Results: Both imported COVID-19 and influenza demonstrated multiple lesions. In the former, the lesions were mostly distributed in the subpleural of peripheral lung (90.9%), and some of them showed an anti-butterfly wing sign (18.2%; P<0.05). In the latter, the lesions were distributed around the bronchial vascular tree with subpleural lesions in peripheral lung (33.3%); nonetheless, they were fewer than those observed in the former (P<0.05). There were some differences in ground-glass opacity (GGO) (95.5% vs. 66.7%, respectively, P<0.05), consolidation (68.2% vs. 12.8%, respectively, P<0.05), and crazy paving sign (86.4% vs. 10.3%, respectively, P<0.05). The air bronchogram sign in the former appeared earlier than those in the latter. When both GGO lesions were mixed, the latter had more solid areas and higher density. Conclusions: The different chest HRCT features of COVID-19 and seasonal influenza pneumonia can provide considerable evidence for the early diagnosis of imported COVID-19 and seasonal influenza pneumonia and can be of great help for the prevention and control of COVID-19.

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Section: Identification Of Covid-19 and Influenza Pneumoniasupporting

confidence: 78%

Value Of High-Resolution Computed Tomography in the Differential Diagnosis of Imported COVID-19 and Seasonal Influenza Pneumonia: Differential Diagnosis of COVID-19 and Influenza Pneumonia using HRCT

2020

ircmj

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“…The detection rate of the radiological findings was 57.8% in influenza A and 66.6% in influenza B, and no statistical difference was determined between these two rates (p=0.493). In the study conducted by Kloth et al, it was also determined that the radiologic pattern had not changed according to the influenza subtypes [23]. In our study, the chest X-ray infiltration detection rates of patients with and without any additional disease that could have affected the immune system were similar (immune system affected patients 66.6% whereas unaffected patients 53.8%, p=0.488).…”

Section: Discussionsupporting

confidence: 63%

“…In our study, the chest X-ray infiltration detection rates of patients with and without any additional disease that could have affected the immune system were similar (immune system affected patients 66.6% whereas unaffected patients 53.8%, p=0.488). Kloth et al, in their study, described similar radiologic findings in computerized tomographic evaluations of influenza patients with and without immune suppression [23]. The comparison of laboratory parameters of the cases obtained by hemogram such as leukocyte, neutrophil, lymphocyte percentage, and the calculated neutrophil/lymphocyte ratio between the groups with and without radiologic infiltration did not reveal any sig- nificant difference.…”

Section: Discussionmentioning

confidence: 60%

Evaluation of clinical and laboratory parameters in patients with influenza pneumonia

Yazıcı¹

2020

Ann Clin Anal Med

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Aim: In this study, we aimed to evaluate clinical and laboratory parameters of the cases diagnosed as influenza pneumonia. Material and Method: The files of the patients treated for confirmed influenza pneumonia either following hospitalization or on an outpatient basis between January 2015 and January 2017 in our hospital were retrospectively evaluated. The cases in whom influenza diagnosis had been confirmed by using multiplex PCR method in samples of nasopharyngeal swabs, sputum or bronchoalveolar lavage fluid were included in the study. Results: Thirty cases of pneumonia with confirmed influenza diagnosis were identified during the mentioned period. 70% of the cases were typed as influenza type A and 30% as influenza type B. The most frequently encountered symptoms were fever (70%) and cough (66.7%). Comorbidities were present in 76.7% of the cases. Medical history of the cases revealed diabetes mellitus (30%), hematologic malignancies (23.3%), and cardiovascular disorders (20%). Radiologic assessment was made in 93.3% of the cases and in 56.7% of them, infiltrations were identified in chest X-ray. CRP level was statistically significantly increased in cases with identified infiltration (p: 0.015). Discussion: Influenza pneumonia probability should not be overlooked when fever and cough symptoms are present in cases having chronic cardiopulmonary comorbidity and clinical conditions in which immune system has been affected during the influenza season. Immunization should be considered and recommended in this patient group. Although radiological evaluation is not necessary in every influenza case, radiologic imaging might be required in patients having a clinical course with elevated CRP levels.

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“…One study reported that in immunocompromised population, CT scans with novel in uenza H1N1 commonly show a strong airway predominance of ndings or peripheral areas of consolidation involving the lower lobes [19]. However, other study mentioned that the CT ndings is not with differences between people in the immunocompetent or immunocompromise when the situation of virus infection [20]. Aged patients' COVID-19 pneumonia recovery manifestation in CT image may need longer follow-up to recognize.…”

Section: Renal Function Is Weaker In Severe Covid-19 Pneumonia Octogementioning

confidence: 99%

Comparison of Clinical Features in Octogenarian and Non-octogenarian Adults with Severe COVID-19 Pneumonia

Shu

Liu

et al. 2020

Preprint

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Background: Aged people is more susceptible and vulnerable to COVID-19 pneumonia. As the “super-elderly” group, octogenarian COVID-19 patients is not rare in current world-wide common healthy event.Object: To describe clinical features in octogenarian with severe COVID-19. And try to find out the differences with other non-octogenarian adult patients.Materials and Methods: We studied a small cohort of octogenarian COVID-19 patients at a hospital in Wuhan from 10 February to 15 March. We recorded interested clinical data including chest CT in the octogenarian patients. In order to know the differences of clinical characteristics between octogenarian and other adult patients, we included the number of non-octogenarian patients cohort as ratio of 1:3.Result: For octogenarian patients, the age is 83.33±3.08 and 4 are female (4/6,66.7%). For non-octogenarian patients, the age is 60.72±8.28 years and 5 are female(5/18, 27.8%). and 59% were men. Compared non-octogenarian patients, octogenarian patients’ hospital stay duration is significantly longer (p=0.0052*). WBC is obvious elevated in octogenarian(p=0.0494*). BUN (p=0.0377*) and Cr (p=0.0112*) is with obvious differences between two group patients. No obvious differences in CT findings between two groups.Conclusion: The severe COVID-19 pneumonia octogenarian may have more chance to combined with bacterial infection. Octogenarian has worse baseline kidney function than non-octogenarian. In individual cases, the broader lesion and more lesion types may be found in octogenarian CT image.

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Comparison of chest-CT findings of Influenza virus-associated pneumonia in immunocompetent vs. immunocompromised patients

Cited by 15 publications

References 19 publications

Value Of High-Resolution Computed Tomography in the Differential Diagnosis of Imported COVID-19 and Seasonal Influenza Pneumonia: Differential Diagnosis of COVID-19 and Influenza Pneumonia using HRCT

Value Of High-Resolution Computed Tomography in the Differential Diagnosis of Imported COVID-19 and Seasonal Influenza Pneumonia: Differential Diagnosis of COVID-19 and Influenza Pneumonia using HRCT

Evaluation of clinical and laboratory parameters in patients with influenza pneumonia

Comparison of Clinical Features in Octogenarian and Non-octogenarian Adults with Severe COVID-19 Pneumonia

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