Comparison of Chemical Compositions and Antioxidant Activities of the Essential Oils of Two<i>Ziziphora</i>. Taxa from Anatolia

Konyalιoğlu, Sibel; Öztürk, Bintuğ; Meral, Gözde

doi:10.1080/13880200600592244

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…Results of the present study demonstrated that the L-NAME control group showed a significantly decreased level of SOD and GSH in the heart tissue. PLG significantly improved the activity of enzymatic antioxidants in L-NAME induced hypertensive rats according to previous reports that proved PLG has free radicle scavenging activity 34,35 . CK-MB and LDH are known to be the standard cardiac markers for identifying cardiac damage.…”

Section: Fig 2: Effect Of Plg (5 10 and 20 Mg/kg) And Verapamil On Hi...supporting

confidence: 76%

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2022

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The present study was aimed to assess the antihypertensive effect of PLG in L-NAME-induced hypertensive rats. Methods: Wistar rats of 200-240g were given L-NAME (40 mg/kg body weight/day/p.o.) in drinking water daily for 4 weeks to induce hypertension. Rats were randomly divided into six groups: control, L-NAME control, Verapamil (20 mg/kg, p.o.), and PLG (5, 10, and 20 mg/kg, p.o.). PLG and standard drug Verapamil (20 mg/kg) was also administered daily for 4 weeks. At the end of the 4th week, hemodynamic and biochemical parameters were evaluated. Result: PLG (10 and 20 mg/kg) significantly (p <0.01 and p <0.001) and dose-dependently decreased the elevated (SBP), (DBP) and (MABP). PLG also prevented the increase in heart weight and body weight. Undesirable changes such as increased (MDA) levels and decreased concentration of enzymatic antioxidants (SOD) and (GSH) in the heart tissue were rectified after the administration of PLG (10 and 20 mg/kg). Oral administration of PLG (10 and 20 mg/kg) also restored altered levels of hepatic and renal markers, lipid profile values, and histological abnormalities. Verapamil (20mg/kg) showed a maximum antihypertensive effect. Meanwhile, we found that NO concentration in plasma and aorta was significantly increased in the PLG (20 mg/kg) treated group. Conclusion:It is suggested that PLG possessed an antihypertensive effect in L-NAME-induced hypertensive Wistar rats. The results thus proposed that the blood pressure-lowering effect of PLG may be due to its antioxidant nature and prevention to decrease the bioavailability of NO. INTRODUCTION:Hypertension is a significant public-health challenge because of its high frequency and concomitant risks of cardiovascular disease throughout the world. In the USA, 45% of adults suffer from hypertension 1 . According to the study, rates of awareness, treatment, and control of hypertension can be increased up to 2030 2 . In preventing or treating cardiovascular diseases, monoterpenes have significant therapeutic potential 3 .

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Section: Fig 2: Effect Of Plg (5 10 and 20 Mg/kg) And Verapamil On Hi...supporting

confidence: 76%

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2022

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“…[ 7 8 9 ] Ziziphora tenuior (ZT) grows on mountain slopes. [ 10 ] The extract of some species of this plant such as Ziziphora clinopodioides and Ziziphora persica is capable of preventing the growth of a wide range of Gram-positive and Gram-negative pathogenic microorganisms. [ 11 12 13 ] Ferula gummosa (FG) has extensive antibacterial properties as well.…”

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confidence: 99%

Comparison of antimicrobial effect of Ziziphora tenuior, Dracocephalum moldavica, Ferula gummosa, and Prangos ferulacea essential oil with chlorhexidine on Enterococcus faecalis: An in vitro study

et al. 2018

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Background:Different irrigating solutions with high antimicrobial activity have been introduced for cleaning of the root canal system. However, effects of Prangos ferulacea (PF), Ziziphora tenuior (ZT), Dracocephalum moldavica (DM), and Ferula gummosa (FG) on oral and dental pathogens have not been extensively evaluated due to their optimal biocompatibility and insignificant side effects. The aim of this study was to evaluate the antibacterial effects of essential oils of mentioned plants on Enterococcus faecalis.Materials and Methods:In this in vitro study the plants were collected from Zanjan Province, Iran. Analysis of the essential oil was carried out by gas chromatography/mass chromatography. Micro-broth dilution and disc diffusion methods were used for assessment of the antimicrobial activity, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated.Results:All the four essential oils had antibacterial effects on E. faecalis, and ZT had the greatest antibacterial activity. Assessment of the mean diameter of the growth inhibition zone showed higher antibacterial activity of PF and ZT than that of chlorhexidine. The MIC and MBC of ZT showed that the antimicrobial activity of ZT against E. faecalis was greater than that of other plants evaluated in this study.Conclusion:The results of this study indicated significant antibacterial effects of the mentioned plants on E. faecalis. The greatest antimicrobial activity belonged to ZT. The current study suggests extraction of effective compounds in these medicinal plants to use them in the clinical setting.

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