Comparison of Chemical and Biological Properties of Metal Nanoparticles (Au, Ag), with Metal Oxide Nanoparticles (ZnO-NPs) and their Applications

Abdussalam-Mohammed, Wanisa

doi:10.33945/sami/ajca.2020.2.8

Cited by 29 publications

(10 citation statements)

References 86 publications

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“…The nanoparticle formation of gambogic acid was also proven to be effective on other cancer cell lines like colorectal cancers by modulating apoptosis process with minimal toxicity to normal cells (Wang et al, 2012). Metal nanoparticles or metal oxide nanoparticles made of Au, TiO 2 , ZnO, and CeO 2 are proven as the effective cancer chemotherapeutic molecules against several cancer cell lines (Abdussalam‐Mohammed, 2020; Berg et al, 2009). Molybdenum trioxide (MoO 3 ) is needed for inducing significant toxicity to the cancer cells mainly against breast cancer cells via mitochondria‐mediated intrinsic apoptotic process (Anh Tran et al, 2014).…”

Section: Nanocarriers and Stemness In Melanomasmentioning

confidence: 99%

Perspectives on the nanocarriers with miRNAs for targeting melanoma stemness through epigenetic regulation

Liu

Zhang

Beeraka

et al. 2023

Pigment Cell Melanoma Res

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Several research reports delineated the significant role of miRNAs in cancer proliferation, and their modulatory role in cancer mitigation, and drug resistance. Melanoma cells have been acquiring stemness to several chemotherapeutic agents through drug efflux proteins, epigenetic modulation, and DNA repair. miRNAs could be applied as novel therapeutic modalities for treating several kinds of cancers to modulate these mechanisms involved in stemness. Nanocarriers to carry these tumor-targeting miR-NAs to modulate stemness are a prominent strategy to overcome their low penetrability, minimal stability, and nonspecificity. We have searched several public databases such as PubMed, Medline, Google scholar, and NLM and obtained the information pertinent to the miRNA-based nanocarrier systems to target stemness through epigenetic modulation in melanomas. This review delineates that various miRNAs can modulate the stemness in melanomas by specific intricate epigenetic signaling, and other cell-based signaling mechanisms. Specific nanocarrier formulations with specific miRNAs are optimal methods to deliver these miRNAs in order to achieve significant entrapment efficiency, loading efficiency, and stability. Furthermore, the combinatorial regimen of FDA-approved chemotherapeutic molecules with tumor-targeting miRNAs and chemotherapy combined with nanocarriers can efficiently deliver the utmost therapeutic window by targeting tumor matrix, invasion, metastasis, and angiogenesis in melanomas. Substantial research should focus on the clinical application of this gene therapy in melanomas using these low immunogenic, highly degradable, and biocompatible combinatorial nanotherapeutic regimens.

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Section: Nanocarriers and Stemness In Melanomasmentioning

confidence: 99%

Perspectives on the nanocarriers with miRNAs for targeting melanoma stemness through epigenetic regulation

Liu

Zhang

Beeraka

et al. 2023

Pigment Cell Melanoma Res

View full text Add to dashboard Cite

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“…Mohanan et al recommends adopting surface functionalization strategies for reducing toxic response of ZnO nanoparticles in various applications [181]. Different strategies of surface modification and functionalization of colloidal ZnO nanoparticles have been reported to lower their toxicity [182]. However, their surface chemistry is not as established as that of silica and alumina and modification of ZnO nanoparticle surface area could lead to release of Zn 2+ ions that enhance ROS production.…”

Section: Fluorescence Detection Of Transition Metal Oxide Nanoparticlesmentioning

confidence: 99%

Current State of Laser-Induced Fluorescence Spectroscopy for Designing Biochemical Sensors

Taylor

Lai

2021

Chemosensors

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Laser-induced fluorescence (LIF) has been a valuable analytical technique since the 1970s that has only been made more useful through advances in other scientific fields such as biochemistry. Moreover, advances in laser and detector technology have seen a decrease in LIF detector costs and an increase in their ease of use. These changes have allowed for LIF technology to be widely adopted for various sensor designs in combination with advanced instruments. With advances in biochemistry necessitating the detection of complex metabolites, labelling with fluorescent chemical reagents may be necessary to improve detection sensitivity. Furthermore, advances made in fluorescent labeling technologies have allowed for the use of LIF in the detection of nanoparticles as well as for imaging techniques using nanoparticles as signal amplifiers. This technology has become invaluable in the detection of environmental pollutants, monitoring of biological metabolites, biological imaging, and cancer diagnosis, making it one of the most valuable analytical science techniques currently available.

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“…Over the past 40 years, nanotechnology greatly impacted both fundamental and applied research, as materials scaled down to the nano range (i.e., nanomaterialsNMs) feature emphasized physical–chemical properties rather than bulk ones . For instance, metal and metalloid [henceforth metal(loid)] NMs exhibit unique electronic, optical, catalytic, and biological properties that make them valuable for a variety of applications. , Many synthetic procedures have been developed to produce metal(loid) NMs. Yet, most of these approaches often involve hazardous chemicals, dangerous operational conditions, and toxic waste that needs to be disposed of .…”

Section: Introductionmentioning

confidence: 99%

Impact of Biogenic and Chemogenic Selenium Nanoparticles on Model Eukaryotic Lipid Membranes

et al. 2023

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Microbial nanotechnology is an expanding research area devoted to producing biogenic metal and metalloid nanomaterials (NMs) using microorganisms. Often, biogenic NMs are explored as antimicrobial, anticancer, or antioxidant agents. Yet, most studies focus on their applications rather than the underlying mechanism of action or toxicity. Here, we evaluate the toxicity of our well-characterized biogenic selenium nanoparticles (bSeNPs) produced by the Stenotrophomonas maltophilia strain SeITE02 against the model yeast Saccharomyces cerevisiae comparing it with chemogenic SeNPs (cSeNPs). Knowing from previous studies that the biogenic extract contained bSeNPs in an organic material (OM) and supported here by Fourier transform infrared spectroscopy, we removed and incubated it with cSeNPs (cSeNPs_OM) to assess its influence on the toxicity of these formulations. Specifically, we focused on the first stages of the eukaryotic cell exposure to these samplesi.e., their interaction with the cell lipid membrane, which was mimicked by preparing vesicles from yeast polar lipid extract or phosphatidylcholine lipids. Fluidity changes derived from biogenic and chemogenic samples revealed that the bSeNP extract mediated the overall rigidification of lipid vesicles, while cSeNPs showed negligible effects. The OM and cSeNPs_OM induced similar modifications to the bSeNP extract, reiterating the need to consider the OM influence on the physical–chemical and biological properties of bSeNP extracts.

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Comparison of Chemical and Biological Properties of Metal Nanoparticles (Au, Ag), with Metal Oxide Nanoparticles (ZnO-NPs) and their Applications

Cited by 29 publications

References 86 publications

Perspectives on the nanocarriers with miRNAs for targeting melanoma stemness through epigenetic regulation

Perspectives on the nanocarriers with miRNAs for targeting melanoma stemness through epigenetic regulation

Current State of Laser-Induced Fluorescence Spectroscopy for Designing Biochemical Sensors

Impact of Biogenic and Chemogenic Selenium Nanoparticles on Model Eukaryotic Lipid Membranes

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