Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.

Jarad, N.A.; Demertzis, Panos; Jones, Debbie; Barnes, NC; Rudd, RM; Gaya, H.; Wedzicha, JA; Hughes, D.; Empey, D. W.

doi:10.1136/thx.51.2.137

Cited by 40 publications

(24 citation statements)

References 8 publications

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“…More recently, however, MAC has increasingly been recognized as a primary infectious agent in immunocompetent patients, especially in females without pre-existing pulmonary disease [1]. Although exposure to MAC often occurs without any clinical manifestation, clinical manifestations may range from no symptoms to signs of destructive or even fatal disease [11]. Interestingly, in the present study, four of the five patients were male and had a history of dust exposure and, consistent with exposure, anthracotic deposits were observed around small airways in the resected lungs.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary disease caused by MAC infection has a wide spectrum of clinical presentations from simple pneumonic infiltrate to progressive destructive disease [11±13]. Many authors believed that in the majority of patients with MAC pulmonary disease there were chronic underlying lung diseases such as pneumoconiosis, bronchiectasis, chronic bronchitis and emphysema [1,11]. More recently, however, MAC has increasingly been recognized as a primary infectious agent in immunocompetent patients, especially in females without pre-existing pulmonary disease [1].…”

Section: Discussionmentioning

confidence: 99%

“…MAC is a ubiquitous pathogen that has been found in soil, domestic tap water and animals [11]. Pulmonary disease caused by MAC infection has a wide spectrum of clinical presentations from simple pneumonic infiltrate to progressive destructive disease [11±13].…”

Section: Discussionmentioning

confidence: 99%

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Pathological and radiological changes in resected lung specimens in Mycobacterium avium intracellulare complex disease

Fujita¹,

Ohtsuki²,

Suemitsu³

et al. 1999

Eur Respir J

114

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The present study was designed to evaluate the pathological and immunohistochemical findings of Mycobacterium avium intracellulare complex (MAC) lung infection.A retrospective study was performed in five cases with positive cultures for MAC in whom lung resections were performed between January 1989 and December 1996. A determination of whether or not MAC caused pulmonary disease was made using the 1997 criteria defined by the American Thoracic Society. In addition, MAC was cultured from all of the five lung specimens. Pathological and immunohistochemical findings as well as chest computed tomography (CT) findings were evaluated in these five patients.Pathological findings of bronchiectasis, bronchiolitis, centrilobular lesion, consolidation, cavity wall and nodules were demonstrated, respectively, in relation to chest CT findings. Extensive granuloma formation throughout the airways was clearly demonstrated. Immunohistochemical staining demonstrated: 1) epithelioid cells and giant cells; 2) myofibroblasts extensively infiltrating the cavity wall; and 3) B-cells detected in aggregates in the vicinity of the epithelioid granulomas.This study identified pathological and immunohistochemical characteristics of Mycobacterium avium complex infection relative to chest computed tomography findings and allowed the conclusion that bronchiectasis and bronchiolitis were definitely caused by Mycobacterium avium complex infection. Eur Respir J 1999; 13: 535±540.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pathological and radiological changes in resected lung specimens in Mycobacterium avium intracellulare complex disease

Fujita¹,

Ohtsuki²,

Suemitsu³

et al. 1999

Eur Respir J

114

View full text Add to dashboard Cite

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“…22 In developing countries, pulmonary symptoms suggestive of mycobacterial disease are almost universally considered to be caused by MTB. 23 As clinical and radiographic features of NTM infections are similar to MTB infection, 24 NTM positive smears could also be misclassified as MTB and receive conventional ATT, which is inappropriate.…”

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confidence: 99%

Public health relevance of non-tuberculous mycobacteria among AFB positive sputa

Desikan

Tiwari

Panwalkar

et al. 2017

GERMS

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“…Pulmonary NTM infections are most frequent and some NTMs such as Mycobacterium kansasii and Mycobacterium abscessus can also cause lung or other infections in apparently healthy subjects; however, infections involving extrapulmonary body sites are also increasing [2, 4-7]. NTM often cause disease that is clinically and radiographically indistinguishable from TB; however, treatment strategies and the prognosis of NTM disease are quite different [2, 5-8]. …”

Section: Introductionmentioning

confidence: 99%

Diversity of Nontuberculous Mycobacteria in Kuwait: Rapid Identification and Differentiation of <b><i>Mycobacterium</i></b> Species by Multiplex PCR, INNO-LiPA Mycobacteria v2 Assay and PCR Sequencing of rDNA

Ahmad¹,

Mokaddas²

2019

Med Princ Pract

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Objective: Nontuberculous mycobacteria (NTM) often cause disease that is clinically indistinguishable from tuberculosis. Specific identification is important as treatment varies according to Mycobacterium species causing the infection. This study used multiplex PCR (mPCR) assay for rapid differentiation of mycobacterial growth indicator tube 960 system (MGIT) cultures as Mycobacterium tuberculosis (MTB) or NTM together with INNO LiPA Mycobacteria v2 assay (LiPA) and/or PCR sequencing of rDNA for species-specific identification of selected MTB and all NTM isolates in Kuwait. Materials and Methods: DNA was extracted from MGIT cultures (n = 1,033) grown from 664 pulmonary and 369 extrapulmonary specimens from 1,033 suspected tuberculosis patients. mPCR was performed to differentiate MTB from NTM. LiPA was performed and results were interpreted according to kit instructions. rDNA was amplified and sequenced by using panmycobacterial primers. Results: mPCR identified 979 isolates as MTB, 53 as NTM and 1 isolate as mixed culture. LiPA and/or PCR sequencing confirmed 112 of 979 selected isolates as MTB. Mixed culture contained M. tuberculosis and M. fortuitum. LiPA yielded 12 patterns and identified 10 species/species complexes among 47 NTM, M. kansasii + M. scrofulaceum in one culture and 5 isolates only at genus level. PCR sequencing yielded more specific identification for 22 isolates at the species/subspecies level. Conclusions: mPCR rapidly differentiated MTB from NTM. LiPA identified 44 of 52 NTM isolates at the species/species complex level and 2 mixed cultures. PCR sequencing yielded more specific identification at the species/subspecies level. Rapid differentiation as MTB or NTM by mPCR, followed by species-specific NTM identification by LiPA/PCR sequencing is suitable for the proper management of mycobacterial infections in Kuwait.

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Comparison of characteristics of patients and treatment outcome for pulmonary non-tuberculous mycobacterial infection and pulmonary tuberculosis.

Cited by 40 publications

References 8 publications

Pathological and radiological changes in resected lung specimens in Mycobacterium avium intracellulare complex disease

Pathological and radiological changes in resected lung specimens in Mycobacterium avium intracellulare complex disease

Public health relevance of non-tuberculous mycobacteria among AFB positive sputa

Diversity of Nontuberculous Mycobacteria in Kuwait: Rapid Identification and Differentiation of <b><i>Mycobacterium</i></b> Species by Multiplex PCR, INNO-LiPA Mycobacteria v2 Assay and PCR Sequencing of rDNA

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