Comparison of central corneal thickness in healthy eyes using ultrasound pachymetry, non-contact specular microscopy and a high-resolution Scheimpflug camera

Soulantzou, Konstantina; Plakitsi, Athina; Chalkiadaki, Evangelia; Anastasopoulou, Maria; Karmiris, Efthymios

doi:10.1007/s10792-022-02431-1

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…The pairwise comparisons showed that measurements obtained with the PM1 pachymeter were slightly lower than UP, with a mean difference of 7.58 μm over a wide range of CCTs. Previous studies have similarly found that CCT measurements with ultrasound are slightly thicker than with optical biometers 13,24–26 . Although statistically significant, the small overall difference in CCT between the PM1 and UP is not clinically significant; however, the 95% LoA ranging from 9.47 μm above to 24.63 μm below would suggest that the two devices are not directly interchangeable and therefore the same device should be used when monitoring CCT over time.…”

Section: Discussionmentioning

confidence: 78%

“…Previous studies have similarly found that CCT measurements with ultrasound are slightly thicker than with optical biometers. 13,[24][25][26] Although statistically significant, the small overall difference in CCT between the PM1 and UP is not clinically significant; however, the 95% LoA ranging from 9.47 μm above to 24.63 μm below would suggest that the two devices are not directly interchangeable and therefore the same device should be used when monitoring CCT over time. Similar results have also been found in agreement studies using optical coherence tomography (OCT), which is currently widely used for quantitative and qualitative evaluation of anterior segment structures in a variety of clinical settings.…”

Section: Discussionmentioning

confidence: 92%

“…Consecutive CCT measurements were then taken with a Pachmate 2 handheld UP. 13 One drop of the topical anaesthetic, 0.5% proxymetacaine hydrochloride (Bausch & Lomb, bausch.co.uk), was instilled into the conjunctival sac to anaesthetise the cornea and the probe was positioned on the central cornea perpendicular to the corneal surface. With the device in 'continuous averaging mode', the pachymeter makes 25 measurements and provides the mean CCT value.…”

Section: Ultrasound Biometrymentioning

confidence: 99%

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Repeatability and agreement of central corneal thickness measurements with a new handheld non‐contact pachymeter

Lawrenson

Gill

Masuid

et al. 2023

Ophthalmic Physiologic Optic

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PurposeTo compare the repeatability of central corneal thickness (CCT) measurements taken with a new handheld pachymeter (Occuity PM1 pachymeter) and to assess its agreement with ultrasound biometry and two commercially available optical biometers in participants with normal eyes.MethodsThree consecutive CCT measurements of the right eye of 105 participants with normal corneas were acquired by the PM1 pachymeter, Lenstar LS 900 and Oculus Pentacam HR in a random order. This was followed by three measurements with a handheld ultrasound pachymeter (UP) (Pachmate 2). Repeatability and the repeatability limit were calculated for each device and Bland–Altman limits of agreement (LoA) were determined for the PM1 pachymeter compared to the other devices.ResultsThe mean CCT (±SD) was 551.04 ± 33.43, 558.62 ± 31.46, 549.41 ± 31.00 and 539.73 ± 29.50 μm for the PM1 pachymeter, UP, Lenstar and Pentacam, respectively. The repeatability limits (expressed as the within subject SD for repeat measurements) were 14.02, 13.68, 4.99 and 9.90 μm, respectively. The closest agreement was between the PM1 and Lenstar (mean difference = −1.63 μm with LoA 10.72 μm below and 13.97 μm above the readings obtained with the Lenstar). The PM1 underestimated CCT compared to UP (mean difference = 7.58 μm, LoA 24.63 μm below and 9.47 μm above UP). The agreement was lowest between the PM1 and Pentacam (mean difference = −11.30 μm, LoA between 4.29 and 26.89 μm).ConclusionsThe PM1 pachymeter shows excellent precision for CCT measurements across a range of corneal thicknesses in normal eyes and provides a safe and easy‐to‐use alternative to ultrasound pachymetry.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 92%

Section: Ultrasound Biometrymentioning

confidence: 99%

See 1 more Smart Citation

Repeatability and agreement of central corneal thickness measurements with a new handheld non‐contact pachymeter

Lawrenson

Gill

Masuid

et al. 2023

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

show abstract

“…Previous studies have similarly found that CCT measurements with ultrasound are slightly thicker than with optical biometers. [20][21][22][23] Although statistically significant, the small overall difference in CCT between the PM1 and ultrasound biometry is not clinically significant, however the 95% limits of agreement ranging from 9.47 µm above to 24.63 µm below would suggest that the two devices are not directly interchangeable and therefore the same device should be used when monitoring CCT over time. Similar results have also been found in agreement studies using optical coherence tomography (OCT), which is currently widely used for quantitative and qualitative evaluation of anterior segment structures in a variety of clinical settings.…”

Section: Discussionmentioning

confidence: 95%

Repeatability and agreement of central corneal thickness measurements with a new handheld non-contact pachymeter

Lawrenson

Gill

Masuid

et al. 2023

Preprint

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Purpose: To compare the repeatability of central corneal thickness (CCT) measurements taken with a new hand-held pachymeter (Occuity PM1 Pachymeter) and to assess its agreement with ultrasound biometry and two commercially available optical biometers in participants with normal eyes. Methods: Three consecutive CCT measurements of the right eye of 105 participants with normal corneas were acquired by the PM1 pachymeter, Lenstar LS900 and Oculus Pentacam HR in a random order. This was followed by three measurements with a hand-held ultrasound pachymeter (UP) (Pachmate-2). Repeatability and the repeatability limit were calculated with each device and Bland-Altman limits of agreement (LoA) were determined for the PM1 pachymeter compared to the other devices. Results: The mean CCT (SD) was 551.04 SD 33.43 μm, 558.62 SD 31.46 μm, 549.41 SD 31.00 μm, and 539.73 SD 29.50 μm for the PM1 pachymeter, UP, Lenstar and Pentacam, respectively. The repeatability limits (expressed as the within subject SD for repeat measurements) were 14.02, 13.68, 4.99 and 9.90 μm respectively. The closest agreement was between the PM1 and Lenstar (mean difference = 1.63 μm with LoA 10.72 μm below and 13.97 μm above the readings obtained with the Lenstar. The PM1 underestimated CCT compared to UP (mean difference = 7.58 μm, LoA 24.63 μm below and 9.47 μm above UP. The agreement was lowest between the PM1 and Pentacam (mean difference= -11.30 μm, LoA between 4.29 μm and 26.89 μm). Conclusions: The PM1 pachymeter shows excellent precision for CCT measurements across a range of corneal thicknesses in normal eyes and provides a safe and easy to use alternative to ultrasound pachymetry.

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Comparison of central corneal thickness measured in myopic eyes by Pentacam, Sirius and IOLMaster 700

Song,

Liu,

Yang

et al. 2024

Photodiagnosis and Photodynamic Therapy

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Comparison of central corneal thickness in healthy eyes using ultrasound pachymetry, non-contact specular microscopy and a high-resolution Scheimpflug camera

Cited by 4 publications

References 35 publications

Repeatability and agreement of central corneal thickness measurements with a new handheld non‐contact pachymeter

Repeatability and agreement of central corneal thickness measurements with a new handheld non‐contact pachymeter

Repeatability and agreement of central corneal thickness measurements with a new handheld non-contact pachymeter

Comparison of central corneal thickness measured in myopic eyes by Pentacam, Sirius and IOLMaster 700

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