Comparison of Cell Suspension Transplantation Prepared From Plucked Hair Shafts, Excised Hair Follicles, and Epidermal Shave Biopsies in Vitiligo Patients: A Randomized Study

Pangti, Rashi; Challa, Apoorva; Chauhan, Suman; Narayanan, Arunachalam; Gupta, Somesh

doi:10.1097/dss.0000000000002337

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…The pellet was resuspended in 250–500 microlitres of DMEM depending on the size of the recipient patch and transplanted onto the recipient site 10 …”

Section: Methodsmentioning

confidence: 99%

Comparison of efficacy of noncultured hair follicle cell suspension and noncultured epidermal cell suspension in repigmentation of leukotrichia and skin patch in vitiligo: a randomized trial

et al. 2020

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Background Vitiligo manifests as hypo-to de-pigmented macules, which are sometimes associated with leukotrichia. For complete cosmetic improvement, the repigmentation of leukotrichia is an important component. Methods This randomized controlled trial included patients with stable vitiligo with leukotrichia. Two vitiligo patches in each patient were randomized to receive either of the two procedures. The patients were followed up for 9 months posttransplantation. The efficacy of hair follicle cell suspension (HFCS) with epidermal cell suspension (ECS) in repigmentation of leukotrichia and skin in vitiligo was compared. Results A total of 20 patients underwent the procedure, and 19 completed the follow-up. The area of the vitiligo patch and the number of leukotrichia in the patches were comparable between the two groups. There was a significant difference in the mean AE S.D. number of cells transplanted between the two groups (5.06 9 10 5 in HFCS vs. 39.8 9 10 5 in ECS, P < 0.0001). The percentage viability of cells and proportion of melanocytes were comparable between the two groups. A total of 10 patients in HFCS and eight patients in ECS had repigmentation of leukotrichia. The mean AE S.D. percentages of depigmented hair showing repigmentation at nine months were 7.42 AE 11.62% in HFCS and 11.42 AE 17.90% in ECS (P = 0.4195), whereas the mean AE S.D. percentage repigmentation of vitiligo patches was 61.58 AE 42.68% in HFCS and 78.68 AE 30.03% in ECS (P = 0.1618). Conclusions The mean number of cells transplanted in the HFCS group was about eight times less than those in ECS. ECS was better than HFCS in repigmentation of leukotrichia and vitiligo, although the difference was not statistically significant.

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“…The pellet was resuspended in 250–500 microlitres of DMEM depending on the size of the recipient patch and transplanted onto the recipient site 10 …”

Section: Methodsmentioning

confidence: 99%

Comparison of efficacy of noncultured hair follicle cell suspension and noncultured epidermal cell suspension in repigmentation of leukotrichia and skin patch in vitiligo: a randomized trial

et al. 2020

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“…The trend of being less invasive led to the introduction of plucked hair follicles as a source of donor tissue. However, it was seen that this had a lower rate of repigmentation compared to follicles extracted with the help of motorized punches 25 . This was because key cell populations involved in repigmentation were left behind while plucking.…”

Section: Donor Site Preparationmentioning

confidence: 94%

Transplantation procedures in vitiligo: What's new

Thakur

Parsad

2022

Dermatological Reviews

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Background: Transplantation plays a pivotal role in vitiligo surgery and has advanced at a galloping pace.Objectives: To enlist the latest developments in vitiligo transplantation surgery.Findings: Advancements in clinico-epidemiological and molecular profiling (CD8, CD45RO, CXCL-9) have enabled us to predict response to treatment better than ever before. The pace of transplantation has been augmented and the hassle of properly orienting the graft has been bypassed. The pallet has been expanded with a better donor to recipient ratio and ease of technique with regard to hair follicle transplants and suspensions. Suspending media have had a makeover, becoming less runner with a greater rate of pigmentation. Science has made the procedure more pocket and equipment friendly, be it in the realm of incubation or inhibition of trypsin. Electrofulguration, cryogens, salicylic and lactic acid, dental burrs, and lasers have made recipient site preparation easier. Adversity has been metamorphosed into an advantage by harvesting and transplanting the cobblestone that appears post-mini-punch grafting. Surgical techniques have been crafted to conform to special sites like the fingers, palmoplantar sites, ears, genitals, and nipple-areola. Conclusion:There have been many significant advancements in the field of vitiligo transplantation surgery in recent years especially in terms of ease of technique, minimal invasiveness, the pain associated with the procedure, and success rates.

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“…Topical therapies, phototherapy, and various transplantation procedures (cellular as well as tissue grafting) are aimed at repigmentation in vitiligo, but may also result in a color mismatch, variegate repigmentation, and/or textural changes due to associated side effects. Noncultured epidermal cell suspension (NCES) transplantation is a commonly used treatment for repigmentation of stable vitiligo patches 1 . We report the utility of this technique in the treatment of iatrogenic dyspigmentation and textural abnormalities in vitiligo patches.…”

Section: Figurementioning

confidence: 99%

“…NCES is a well‐established treatment modality for the treatment of depigmentation in stable vitiligo, nevus depigmentosus, piebaldism, postinflammatory hypopigmentation, and postburn depigmentation with excellent results 1,5 . The ReCell technique for stable vitiligo, similar to NCES, is a portable battery‐operated cell‐harvesting device which uses sodium lactate as cell delivery system and for dilution of the cell suspension.…”

Section: Figurementioning

confidence: 99%

“…1,5 The ReCell technique for stable vitiligo, similar to NCES, is a portable battery-operated cell-harvesting device which uses sodium lactate as cell delivery system and for dilution of the cell suspension. Though ReCell has advantages of eliminating the need for either a separate laboratory set-up or equipment like centrifuge or incubator to process the cell suspension preparation, not much literature is available on its efficacy, color match and long-term retention of repigmentation.…”

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confidence: 99%

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Autologous noncultured epidermal cell suspension for treatment of iatrogenic variegate repigmentation, textural changes, and color mismatch in vitiligo

Taneja

Sahni

Gupta

2020

Dermatologic Therapy

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Comparison of Cell Suspension Transplantation Prepared From Plucked Hair Shafts, Excised Hair Follicles, and Epidermal Shave Biopsies in Vitiligo Patients: A Randomized Study

Cited by 6 publications

References 5 publications

Comparison of efficacy of noncultured hair follicle cell suspension and noncultured epidermal cell suspension in repigmentation of leukotrichia and skin patch in vitiligo: a randomized trial

Comparison of efficacy of noncultured hair follicle cell suspension and noncultured epidermal cell suspension in repigmentation of leukotrichia and skin patch in vitiligo: a randomized trial

Transplantation procedures in vitiligo: What's new

Autologous noncultured epidermal cell suspension for treatment of iatrogenic variegate repigmentation, textural changes, and color mismatch in vitiligo

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