Comparison of Cause Distribution between Elderly and Non-Elderly Patients with Chronic Cough

Wei, Weili; Yu, Li; Lü, Hanjing; Wang, Lan; Shi, Cuiqin; Ma, Wei; Huang, Yang; Qiu, Zhongmin

doi:10.1159/000142942

Cited by 42 publications

(38 citation statements)

References 53 publications

(36 reference statements)

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“…Because the incidence of cardiovascular disease is associated with age, elderly people are might expected to have ACEI-induced cough more frequently [55]. …”

Section: Introductionmentioning

confidence: 99%

Epidemiology of cough in relation to China

Lai

Pan

Chen

et al. 2013

Cough

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Cough is one of the most common complaints for which patients seek medical attention. Misdiagnosis and mistreatment of cough exist commonly in China. The prevalence of acute cough caused by upper airway infection fluctuates between 9% and 64% in the community, for chronic cough, the prevalence >10% in most surveys, ranging from 7.2%-33%. The common causes of chronic cough are upper airway cough syndrome (previously called as post nasal drip syndrome [PNDS]), cough variant asthma (CVA), gastroesophageal reflux related cough (GERD) and eosinophilic bronchitis (EB). There is a regional discrepancy regarding the prevalence of common causes of cough and distribution of gender among China, UK, USA, the most common cause of chronic cough in China are CVA, followed by UACS, EB and atopic cough (AC), the male is almost equal to female in numbers in China. The risk factors for cough includes cold air, smoking, environmental pollutants, noxious substances and allergens, and unreasonable diet habits.

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“…Because the incidence of cardiovascular disease is associated with age, elderly people are might expected to have ACEI-induced cough more frequently [55]. …”

Section: Introductionmentioning

confidence: 99%

Epidemiology of cough in relation to China

Lai

Pan

Chen

et al. 2013

Cough

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“…Cough is attributed to various causes [15,16,17,18]. Persistent cough due to asthmatic and nonasthmatic causes might involve different mechanisms since asthmatic cough is elicited by bronchoconstriction whereas nonasthmatic cough might be primarily ascribed to increased cough sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Plasma Substance P Levels in Patients with Persistent Cough

et al. 2011

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Background: Substance P (SP) is involved in the pathogenesis of cough in animal models. However, few studies in humans have been reported and the roles of SP in clinical cough remain obscure. Objectives: To clarify the relevance of plasma levels of SP in patients with persistent cough. Methods: We studied 82 patients with cough persisting for at least 3 weeks and 15 healthy controls. Patients were classified as having asthmatic cough (cough-variant asthma and cough-predominant asthma; n = 61) or nonasthmatic cough (n = 21; postinfectious cough, n = 6; gastroesophageal reflux disease, n = 5; idiopathic cough, n = 5, and others, n = 5). Correlations were evaluated between plasma SP levels as measured with ELISA and methacholine airway hyperresponsiveness (airway sensitivity and airway reactivity), capsaicin cough sensitivity, sputum eosinophil and neutrophil counts, and pulmonary function. Results: Plasma SP levels were significantly elevated in patients with both asthmatic and nonasthmatic cough compared with controls [31.1 pg/ml (range 18.0–52.2) and 30.0 pg/ml (range 15.1–50.3) vs. 15.4 pg/ml (range 11.3–23.7); p = 0.003 and p = 0.038, respectively] but did not differ between the two patient groups (p = 0.90). Plasma SP levels correlated with airway sensitivity (threshold dose of methacholine) in the patients with asthmatic cough (r = –0.37, p = 0.005) but not with airway reactivity, cough sensitivity, FEV₁ values, or sputum eosinophil and neutrophil counts in either group. Conclusions: Increased levels of SP in plasma are associated with persistent cough in humans and might be related to airway sensitivity in asthmatic cough.

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“…This protocol requires laboratory investigations, including histamine bronchial provocation testing, induced sputum cytology and 24‐h monitoring of oesophageal pH. The diagnostic criteria for causes of chronic cough were based on the published literature 2,10–15 . CVA was diagnosed when patients presented with evidence of BHR, and the cough was relieved at the first or second step of therapy.…”

Section: Methodsmentioning

confidence: 99%