Comparison of caudal bupivacaine, bupivacaine-morphine and bupivacaine-midazolam mixtures for post-operative analgesia in children

Güleç, Sacit; Büyükkidan, B.; Oral, N.; Özcan, N.; Tanriverdi, Belkıs

doi:10.1097/00003643-199803000-00007

Cited by 19 publications

(5 citation statements)

References 19 publications

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“…However, other studies have shown that patients treated with intrathecal midazolam showed a better satisfaction score due to reduced pain and quality of anesthesia in the VAS test (P˂0.001) (58,79,80). Also, in other studies, in patients receiving midazolam, the amount of relaxation and reduction of postoperative pain was higher and, consequently, patients' satisfaction was more and more significant compared to the control group [48][49][50][51][52][53][54][55][56][57]. Although the result of our study was not significant in this index, but according to the observations and studies, since midazolam with bupivacaine causes a long period of anesthesia and better pain relief and fewer side effects, patients feel more satisfied.…”

Section: Discussionmentioning

confidence: 78%

Efficacy of Adding Midazolam to Bupivacaine (0.5%) on the Duration of Spinal Anesthesia in Unilateral Inguinal Hernia Surgery

Kayalha,

Movahed,

Karbord

et al. 2023

J Clin Res Case Stud

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Introduction: Inguinal hernia is the most common type of abdominal hernia which is 7 times more common in men than women. Surgical treatment is performed under general or local anesthesia (spinal or epidural). Neuraxial anesthesia has a greater advantage than general anesthesia. Today, spinal block anesthetics with local drug anesthetics along with adjuvant drugs is widely used for surgery. Midazolam is one of these adjuvants whose spinal injection, in addition to its appropriate analgesic effect, enhances the effect of local anesthetics. Aim: The aim of this study was to determine the effect of intrathecal midazolam (1 mg) to bupivacaine (0.5%) on the quality and timing of sensory block, motor block and hemodynamic changes during of inguinal herniation surgery. Materials and Methods: 64 patients with ASAI / II criteria (30-70 years old) were randomly divided into two groups of 32 patients under spinal anesthesia for inguinal herniation surgery. The anesthesiologist and the patient did not know the status of the studied drugs. Group 1 received 0.5 ml of bupivacaine 0.5% + 0.2 ml of normal saline and group 2 received 3 ml of bupivacaine 0.5% + 0.2 ml of midazolam (1 mg). The return time of sensory block and the return time of motor block, the time of the first request for analgesics, the degree of satisfaction and the hemodynamic status were compared between these group. Results: The return time of sensory block in group 1 was 124.81 ± 16.15 minutes and in group 2 was 193.18± 34.53 minutes, which was statistically significant and in group 2 the return time of sensory block was longer (001 ≤. ˂P). reaction block return time: in group 2: (140.43 ± 27.46) minutes, group: 1 (107.78 ± 13.82) minutes were shorter and statistically significant (P≤ .001). The time of the first analgesic request by patients in group 1 was 157.87 ±16.32 minutes and in group 2, 264.59 ± 50.17 minutes, which was statistically significant (P ≤ .001). Satisfaction index and hemodynamic changes were not significant between groups (P ˃ 0.05). Conclusion: Addition of 1 mg of midazolam in spinal anesthesia with bupivacaine 0.5% increased of the duration of analgesia and the time of first request for analgesia without changing the hemodynamic status in patients with inguinal herniation surgery.

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Section: Discussionmentioning

confidence: 78%

Efficacy of Adding Midazolam to Bupivacaine (0.5%) on the Duration of Spinal Anesthesia in Unilateral Inguinal Hernia Surgery

Kayalha,

Movahed,

Karbord

et al. 2023

J Clin Res Case Stud

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“…Various studies have Neurotoxicity with midazolam 909 shown that analgesia might be provided by intrathecal or epidural administration of midazolam in human beings in the postoperative period and chronic back pain [3,[17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Neurotoxicity with single dose intrathecal midazolam administration

Uğur

Basaloglu

Yurtseven

et al. 2005

European Journal of Anaesthesiology

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“…These results are very important so this study showed that clinically useful doses of intrathecal or epidural midazolam were not neurotoxic. In the same year, Gulec et al showed that caudal administration of a bupivacaine-midazolam mixture produces a longer duration of postoperative analgesia than a bupivacaine-morphine mixture and bupivacaine alone [53]. Batra et al in 1999, conducted a study on postoperative analgesia in patients undergoing knee arthroscopy following intrathecal administration of midazolam in combination with hyperbaric bupivacaine [54].…”

Section: Topics In Spinal Anaesthesiamentioning

confidence: 99%

Midazolam in Spinal Anesthesia — Intrathecal or Intravenous?

Zencirci¹

2014

Topics in Spinal Anaesthesia

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Comparison of caudal bupivacaine, bupivacaine-morphine and bupivacaine-midazolam mixtures for post-operative analgesia in children

Cited by 19 publications

References 19 publications

Efficacy of Adding Midazolam to Bupivacaine (0.5%) on the Duration of Spinal Anesthesia in Unilateral Inguinal Hernia Surgery

Efficacy of Adding Midazolam to Bupivacaine (0.5%) on the Duration of Spinal Anesthesia in Unilateral Inguinal Hernia Surgery

Neurotoxicity with single dose intrathecal midazolam administration

Midazolam in Spinal Anesthesia — Intrathecal or Intravenous?

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