“…Three of them, which included patients with prior cardiac valvular surgery or previous percutaneous interventions for mitral rheumatic stenosis, reported a very limited efficacy after a single procedure that increased to 70% when repeat procedures-more than half of the total-were included. 53,55,56 In fact, the peculiar electroanatomical atrial substrate determined by rheumatic heart disease is characterized by profound structural remodeling, extensive fibrosis and collagen replacement, requiring consequently extreme substrate modification to achieve stable SR. 67,68 Of note, the prevalence of persistent AF among the included population was relatively high, and this may have influenced the considerable prevalence of LA extensive ablation protocols. Indeed, CHF patients, and even more so patients with HCM or valvular disease, present significant structural remodeling, resulting in a higher risk of persistent AF development as compared with ''lone'' AF.…”