Comparison of casual, ambulatory and self-measured blood pressure in a study of nitrendipine vs bisoprolol

Abstract

In a double-blind, placebo-controlled study the antihypertensive efficacy and tolerability of a single morning dose of either 10 mg bisoprolol (n = 26) or 20 mg nitrendipine (n = 27) were investigated. Blood pressure was measured by three techniques: (1) Casual blood pressure 24 h after the dose; (2) ambulatory 24-h whole-day monitoring; and (3) self-recorded blood pressure in the morning 24 h after the dose (6-8 a.m.) and in the evening (6-8 p.m.). After 4 weeks of therapy bisoprolol had produced a highly significant reduction in blood pressure as assessed by causal, ambulatory day- and night-time monitoring, and self-measured morning and evening readings. Bisoprolol was significantly more effective than nitrendipine, which did not induce a significant reduction in the ambulatory night-time recordings. Whole-day ambulatory blood pressure profiles showed an antihypertensive effect of bisoprolol throughout the entire 24-h period. 24-h blood pressure curves after nitrendipine demonstrated a markedly shorter duration of action, with no reduction in early morning blood pressure. Adverse effects and tolerability of the two drugs were comparable. The average changes in systolic and diastolic blood pressure after bisoprolol and nitrendipine in 2-h periods of ambulatory monitoring (6-8 a.m. and 6-8 p.m.) and self-measured blood pressure (6-8 a.m. and 6-8 p.m.) showed a good agreement between ambulatory and self-measured blood pressure determinations with no significant difference between the methods. The results show that 24 h antihypertensive efficacy was more pronounced for bisoprolol than for nitrendipine at the doses studied.(ABSTRACT TRUNCATED AT 250 WORDS)

In Silico Comparison Between Metoprolol Succinate and Bisoprolol on 24-Hour Systolic Blood Pressures

“…Using the same regression model and covariance, simulated individual 24-h ABPM bp sys values were built from the data created for the bisoprolol and metoprolol CR/ZOK data sets, respectively. Published information on variance of bp sys is generally based on office or summary recordings, and is smaller than the observations of individual time points in ABPM [ 13 ]. For this reason, and on the basis of the available ABPM source data, the standard deviation (SD) of the simulated values was expanded by ≈4 mmHg.…”

Clinical Assessment of Early Morning Blood Pressure in Patients With Hypertension

“…29 After 4 weeks of treatment in a population of 25 patients with essential HTN, bisoprolol reduced mean morning BP level from 145/97 mm Hg to 133/88 mm Hg. 29 Similarly, the calcium channel blocker amlodipine lowers morning systolic BP level and reduces the magnitude of the morning systolic BP surge. In 38 hypertensive patients allocated to a regimen of amlodipine (2.5-10 mg) administered immediately after breakfast for a period of 8 to 16 weeks, mean morning systolic BP level decreased from 156 mm Hg to 142 mm Hg, and the morning surge was reduced by 6.1 mm Hg.…”

“…The use of agents with a long half‐life may also be an effective strategy for enhancing the control of BP in the early morning. For example, a single 10‐mg dose of the β‐blocker bisoprolol administered in the morning has been an effective means for reducing BP during an entire 24‐hour period 29 . After 4 weeks of treatment in a population of 25 patients with essential HTN, bisoprolol reduced mean morning BP level from 145/97 mm Hg to 133/88 mm Hg 29 .…”

“…For example, a single 10‐mg dose of the β‐blocker bisoprolol administered in the morning has been an effective means for reducing BP during an entire 24‐hour period 29 . After 4 weeks of treatment in a population of 25 patients with essential HTN, bisoprolol reduced mean morning BP level from 145/97 mm Hg to 133/88 mm Hg 29 . Similarly, the calcium channel blocker amlodipine lowers morning systolic BP level and reduces the magnitude of the morning systolic BP surge.…”

Anti-ischemic and antiarrhythmic effectiveness of long-term bisoprolol therapy in patients with myocardial infarction

“…5-15 % больных из числа выписавшихся из стационара умирает в течение первого года, последующая ежегодная летальность составляет 2-5 %. У 27-60 % больных в ближайшие или отдаленные сроки развивается сердечная недостаточность (СН), у 74-95 % выявляются различные формы желудочковых аритмий (ЖА) [1][2][3][4][5][6][7]. Столь высокая медико-социальная значимость ИМ определяет необходимость дальнейшего совершенствования и разработки эффективных и экономически доступных методов его вторичной профилактики.…”