Comparison of Cardiovascular Responses to Noise During Waking and Sleeping in Humans

Nisi, J. Di; Muzet, Alain; Ehrhart, J; Libert, Jean‐Pierre

doi:10.1093/sleep/13.2.108

Cited by 53 publications

(26 citation statements)

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“…As regards to the vasomotricity, there is a strong reactivity to stimuli, since the mean values of vasoconstriction varied between 14 and 27%, confirming other studies carried out in adults [35] and in neonates [6,25] in different various experimental conditions.…”

Section: Discussionsupporting

confidence: 86%

“…In these tests, the ability to react was monitored by following either heart rate or respiratory reaction, and/ or arousal and sleep stages modifications but these responses are not specific of the sympathetic response. A specific sympathetic response has been studied by the detection of the vasomotor response to standardized stimulus in adults [34,35], which was sensitive and proportional to the intensity to noise stimulus, but this has never been proved in premature neonates.…”

Section: Introductionmentioning

confidence: 99%

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Vasomotor Reactivity in Premature Neonates at Term

Ducrocq

Broca²,

Abdiche

et al. 2002

Neonatology

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In order to assess the specific sympathetic reactivity in premature infants at term, we designed a study to evaluate the peripheral vasomotor response of such infants when exposed to auditory challenges. Testing was performed in 29 premature neonates at term in both quiet and active sleep during a morning session. Two types of noises were used (click and continuous tones) at three frequencies (250, 1,000 and 6,000 Hz) and at three intensities (60, 85 and 110 dBA). Vasomotor response was studied by analyzing with Mathlab^® software the variability of the plethysmographic wave of the oxymetric pulse. No behavioral awakening was observed in response to any stimulation. When a tachycardia or a bradycardia reaction to the stimuli was observed, all neonates responded with a vasoconstriction. The global mean of the vasoconstrictive response was 18.45%. The overall ANOVA on the vasomotor response revealed significant effects for sleep stages (t: 1.98; p < 0.05), for frequency (t: 3.3; p < 0.001) and for intensity of noise (t: 3.01; p < 0.03) but no significant response with heart rate variability. From these results, we could conclude that the assessment of the vasomotor response is a very sensitive procedure to determine the reactivity of the autonomic nervous system in neonates, and could be used to study such vegetative responses in other stressful situations with good accuracy.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Vasomotor Reactivity in Premature Neonates at Term

Ducrocq

Broca²,

Abdiche

et al. 2002

Neonatology

View full text Add to dashboard Cite

show abstract

“…32 This could include a disturbance within the reticular formation of the brainstem, which integrates facilitory inputs, such as ascending pathways from auditory receptors, and inhibitory inputs from the cortex. 33,34 Intracortical motor inhibition induced by sleep deprivation could also contribute to the central mechanism. 35 …”

Section: Discussionmentioning

confidence: 99%

Decreased Arousals Among Healthy Infants After Short-Term Sleep Deprivation

et al. 2004

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Short-term sleep deprivation among infants is associated with the development of obstructive sleep apnea and significant increases in arousal thresholds. As already reported, sleep deprivation may induce effects on respiratory control mechanisms, leading to impairment of ventilatory and arousal responses to chemical stimulation and decreases in genioglossal electromyographic activity during REM sleep. These changes in respiratory control mechanisms could contribute to the development of obstructive apnea. The relationship between the development of obstructive apnea and increases in arousal thresholds remains to be evaluated. Adult subjects with obstructive sleep apnea exhibited both sleep fragmentation and increases in arousal thresholds. Conversely, sleep deprivation increased the frequency and severity of obstructive sleep apnea. In this study, the increases in arousal thresholds and the development of obstructive apnea seemed to result from the preceding sleep deprivation. The depressed arousals that follow sleep deprivation have been attributed to central mechanisms, rather than decreases in peripheral sensory organ function. Such mechanisms could include disturbances within the reticular formation of the brainstem, which integrates specific facilitory inputs, such as ascending pathways from auditory receptors, and inhibitory inputs from the cortex. It remains to be determined whether the combination of upper airway obstruction and depressed arousability from sleep contributes to the increased risk of sudden death reported for sleep-deprived infants.

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“…7 Nighttime noise exposures may be especially harmful and have been associated with elevated blood pressure, 8,9 and a greater cardiovascular response when compared to daytime noise exposures. 9,10 Environmental noise can also lead to sleep disruption, psychosocial stress, general annoyance, disturbance of daytime activities, and auditory effects. [11][12][13][14] Exposures to air pollutants are also associated cardiovascular morbidity.…”

Section: Introductionmentioning

confidence: 99%

Spatial Variation in Environmental Noise and Air Pollution in New York City

et al. 2014

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Exposure to environmental noise from traffic is common in urban areas and has been linked to increased risks of adverse health effects including cardiovascular disease. Because traffic sources also produce air pollutants that increase the risk of cardiovascular morbidity, associations between traffic exposures and health outcomes may involve confounding and/or synergisms between air pollution and noise. While prior studies have characterized intraurban spatial variation in air pollution in New York City (NYC), limited data exists on the levels and spatial variation in noise levels. We measured 1-week equivalent continuous sound pressure levels (L eq ) at 56 sites during the fall of 2012 across NYC locations with varying traffic intensity and building density that are routinely monitored for combustion-related air pollutants. We evaluated correlations among several noise metrics used to characterize noise exposures, including L eq during different time periods (night, day, weekday, weekend), L dn (day-night noise), and measures of intermittent noise defined as the ratio of peak levels to median and background levels. We also examined correlations between sound pressure levels and co-located simultaneous measures of nitric oxide (NO), nitrogen dioxide (NO 2 ), fine particulate matter (PM 2.5 ), and black carbon (BC) as well as estimates of traffic and building density around the monitoring sites. Noise levels varied widely across the 56 monitoring sites; 1-week L eq varied by 21.6 dBA (range 59.1-80.7 dBA) with the highest levels observed during the weekday, daytime hours. Indices of average noise were well correlated with each other (r9 0.83), while indices of intermittent noise were not well correlated with average noise levels (rG0.41). One-week L eq correlated well with NO, NO 2 , and EC levels (r=0.61 to 0.68) and less so with PM 2.5 levels (r=0.45). We observed associations between 1-week noise levels and traffic intensity within 100 m of the monitoring sites (r = 0.58). The high levels of noise observed in NYC often exceed recommended guidelines for outdoor and personal exposures, suggesting unhealthy levels in many locations. Associations between noise, traffic, and combustion air pollutants suggest the possibility for confounding and/or synergism in intraurban epidemiological studies of traffic-related health effects. The different spatial pattern of intermittent noise compared to average noise level may suggest different sources.Kheirbek, Ito, Kim, Johnson, and Matte are with the New York City

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Comparison of Cardiovascular Responses to Noise During Waking and Sleeping in Humans

Cited by 53 publications

References 0 publications

Vasomotor Reactivity in Premature Neonates at Term

Vasomotor Reactivity in Premature Neonates at Term

Decreased Arousals Among Healthy Infants After Short-Term Sleep Deprivation

Spatial Variation in Environmental Noise and Air Pollution in New York City

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