Comparison of capnovolumetry‐derived dead space parameters with pulmonary function test in normal adults using histamine provocation

Sun, Xiaoli; Yan, Zhang; Yang, Wenlan

doi:10.1111/crj.12133

Cited by 4 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The roles of capnographic parameters in different respiratory diseases have already been described previously [6,29,30], and in our first study [7] we identified the four most important parameters regarding airway obstruction. In the present study, these parameters were used to provide a map of the associations between capnovolumetric indices themselves as well as to the additional diagnostic categories of asthma and COPD.…”

Section: Clinical Interpretationmentioning

confidence: 65%

Correspondence between Capnovolumetric and Conventional Lung Function Parameters in the Diagnosis of Obstructive Airway Diseases

et al. 2020

View full text Add to dashboard Cite

Background: Capnovolumetry is of interest as a method for the diagnosis of obstructive airway diseases, requiring little cooperation from the patient. Objective: To help in the interpretation of capnovolumetric parameters, we aimed to identify their correspondence to conventional lung function indices. Methods: We studied 978 patients from a diagnostic study with complete functional data and the clinical diagnosis of asthma, chronic obstructive pulmonary disease (COPD), or no respiratory disease. Using path analysis, four capnovolumetric parameters (slope of expiratory phase 3, ratio of slopes of phases 3 and 2, volume of phase 2, and the ratio area/volume of phase 3) previously identified as predictors of airway obstruction in terms of spirometry and body plethysmography, were analyzed regarding their relationship to each other and the diagnostic categories of asthma or COPD versus control, or obstruction versus no obstruction. We then identified four lung function parameters showing relationships as much as possible isomorphic to those between capnovolumetric parameters. Results: The four capnovolumetric parameters were related to COPD and obstruction via both direct and indirect influences, but only two of them to asthma. Regarding the correspondence to lung function parameters, the slope of expiratory phase 3 corresponded best to the ratio of residual volume to total lung capacity, the ratio of slopes of phases 3 and 2 to forced expiratory volume in 1 s, the volume of phase 2 to forced expired flow at 50% of vital capacity, and the ratio area/volume of phase 3 to forced vital capacity. Conclusions: Our results indicated an intricate relationship of capnovolumetric parameters to each other and to airway obstruction, asthma, or COPD. The correspondence to conventional lung function measures seemed to reflect the entities lung hyperinflation, overall ventilatory impairment, bronchoconstriction, and ventilated lung volume, in that order. These findings might be helpful for clinicians in the interpretation of capnovolumetry.

show abstract

Section: Clinical Interpretationmentioning

confidence: 65%

Correspondence between Capnovolumetric and Conventional Lung Function Parameters in the Diagnosis of Obstructive Airway Diseases

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In the laboratory, the constriction or relaxation of the airway smooth muscle could be induced by airway stimulating agents, such as histamine or salbutamol ( 17 ). The airway dead space and its dynamic changes could be readily measured by VCap as demonstrated in our previous study ( 13 ). In the current study, we demonstrated that VCap could be used to assess pulmonary function in patients with cough variant asthma.…”

Section: Discussionmentioning

confidence: 98%

“…Volumetric capnography (VCap) was performed as described previously ( 13 ). Briefly, long-acting β2-agonists, antihistamines, and oral corticosteroids were discontinued 48h before the test.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed measurement methods and calculations of VCap values, including dead space volumes [Fowler dead space (VD-F), Wolff dead space (VD-W), threshold dead space (VD-T), Bohr dead space (VD-B)], were the same as described previously ( 13 ). Briefly, under calm breathing, VCap was undertaken in three phases ( Figure 1 ) with exhaled CO 2 concentration or partial pressure shown on the vertical axis in the capnogram.…”

Section: Methodsmentioning

confidence: 99%

“…Studies have shown that VCap could be used as a quantitative method to diagnose and evaluate pulmonary functions in patients with chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease ( 11 , 12 ). Previously, we also demonstrated that VCap could be applied to measure dynamic changes of airway dead space with bronchodilator use in healthy subjects ( 13 ). However, its role in the diagnosis and evaluation of pulmonary functions in patients with cough variant asthma is unclear and has not been studied.…”

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Diagnostic value of volumetric capnography in patients with chronic cough variant asthma

Sun

Yang

Gong

et al. 2020

Clinics

Self Cite

View full text Add to dashboard Cite

Pediatric gastroenterologists, family members, and caregivers of patients with inflammatory bowel disease (IBD) are on alert; they are all focused on implementing prophylactic measures to prevent infection by severe acute respiratory syndrome coronavirus 2, evaluating the risks in each patient, guiding them in their treatment, and keeping IBD in remission. To face the current issues of the coronavirus disease pandemic, we have developed a synthesis of the main recommendations of the literature directed at pediatric gastroenterologists in control of patients with pediatric IBD and adapted to the national reality. ' CLINICAL MANIFESTATIONS Clinical manifestations of COVID-19 include the same symptoms as those found in other flu-like syndromes, for example, headache, fever, cough, coryza, odynophagia, myalgia, and anorexia (11). Throughout the evolution of the pandemic and the increase in case descriptions, diarrhea, vomiting, and anorexia

show abstract

Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children

Vuljanko

Turkalj

Nogalo

et al. 2017

Allergologia et Immunopathologia

View full text Add to dashboard Cite

show abstract

Comparison of capnovolumetry‐derived dead space parameters with pulmonary function test in normal adults using histamine provocation

Cited by 4 publications

References 24 publications

Correspondence between Capnovolumetric and Conventional Lung Function Parameters in the Diagnosis of Obstructive Airway Diseases

Correspondence between Capnovolumetric and Conventional Lung Function Parameters in the Diagnosis of Obstructive Airway Diseases

Diagnostic value of volumetric capnography in patients with chronic cough variant asthma

Diagnostic value of a pattern of exhaled breath condensate biomarkers in asthmatic children

Contact Info

Product

Resources

About