"Comparison of Calcium, Chlorine, Iodine, Potassium, Magnesium, Manganese, and Sodium in Thyroid Tissue Adjacent to Thyroid Malignant and Benign Nodules"

Zaichick, Vladimir

doi:10.26717/bjstr.2022.42.006687

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…The ratios of means and the comparison of mean values of Ag, Co, Cr, Fe, Hg, I, Rb, Sb, Sc, Se, and Zn mass fractions in pair of sample groups such as NT and TBN, NT and TMN, and also TBN and TMN is presented in Table 2. The comparison of our results with published data (from 1990 year) for I mass fraction in NT [27,28,[31][32][33][34]37,[53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72], TBN [54,56,57,62,63,[67][68][69][70][71][72][73][74][75][76][77][78][79][80], and TMN [54,56,…”

Section: Resultsmentioning

confidence: 56%

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Zaichick¹

2022

World J. Adv. Res. Rev.

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Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in trace elements (TEs) contents in nodular tissue for diagnosis of thyroid malignancy. Contents of TEs such as silver (Ag), cobalt (Co), chromium (Cr), iron (Fe), mercury (Hg), iodine (I), rubidium (Rb), antimony (Sb), scandium (Sc), selenium (Se), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using non-destructive instrumental neutron activation analysis. It was observed that in TMN tissue the mean mass fraction of I was lower while the mean mass fraction of Rb was higher than in NT and TBN tissue. It was demonstrated that I content in nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue was significantly higher than that using US examination and cytological test of fine needle aspiration biopsy. It was concluded that determination of the I level in a needle biopsy of TNs using non-destructive instrumental analytical method is a fast, reliable, and very informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification.

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Section: Resultsmentioning

confidence: 56%

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Zaichick¹

2022

World J. Adv. Res. Rev.

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“…Most often, in studies of ChE in the mammary gland, samples of visually intact tissue adjacent to the tumor are used. However, we have previously shown that the intact tissue adjacent to the thyroid tumors in terms of the level of ChE content is not identical to the normal thyroid gland tissue of apparently healthy individuals [59,60] . Therefore, in our review of reported data, only results obtained from the study of normal mammary glands of apparently healthy women were used.…”

Section: Discussionmentioning

confidence: 99%

“…However, it should be noted that the variations of published mean values for some of the studied ChE are very large and amounts to several mathematical orders. The obtained data of the studied ChE content in healthy breast tissue were compared with the reference values of the content of these ChE in blood serum [5,54] , adipose tissue [2,55] , prostate [56] and thyroid [34,[57][58][59][60] human gland (Table 4). Wherein, published data on the water content in breast tissue [61] and the results of report No.…”

Section: Discussionmentioning

confidence: 99%

Contents of twelve chemical elements in normal human breast determined using inductively coupled plasma atomic emission spectrometry

Zaichick,

Dogadkin,

Gromya

et al. 2024

Appl. Chem. Eng.

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Inductively coupled plasma atomic emission spectrometry (ICP-AES) has been shown to be an effective method for determining the content of Al, Ca, Cu, Fe, K, Mg, Na, P, S, Si, Sr and Zn in small mass samples of breast tissue. The method is relatively simple and applicable directly in the clinic for express diagnostics. The autopsy material of 38 practically healthy women aged 16–60 years who died suddenly was studied using the developed method of ICP-AES. Mean values (M ± SD) of mass fractions (mg kg-1 of dry tissue) of chemical elements in normal breast tissue of women were: Al 3.62 ± 2.44, Ca 77.7 ± 61.8, Cu 1.03 ± 1.01, Fe 13.8 ± 12.3, K 194 ± 114, Mg 18.5 ± 9.0, Na 686 ± 516, P 201 ± 74, S 385 ± 224, Si 8.75 ± 6.22b, Sr 0.50 ± 0.24, and Zn 3.29 ± 1.65. The ability of breast tissue to absorb Al, Fe and Sr from the interstitial fluid was revealed. The selective accumulation of Al, Fe, and Sr should be taken into account in further studies of the role of chemical elements in the etiology of breast pathologies, as well as in the development of methods for the differential diagnosis of diseases, for example, benign and malignant tumors of the mammary gland.

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“…Most often, in studies about TE in the mammary gland, samples of visually intact tissue adjacent the tumor are used. However, we have previously shown that the intact tissue adjacent to the thyroid tumors in terms of the level of TE content is not identical to the normal thyroid gland tissue of apparently healthy individuals [53,54]. Therefore, in our review of reported data, only results obtained from the study of normal mammary glands of apparently healthy women were used.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes of trace element contents in normal human breast investigated using inductively coupled plasma mass spectrometry

Zaichick,

Dogadkin,

Tyurin

et al. 2023

Preprint

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The etiology of breast cancer remains largely unclear, however, it is well known that the incidence of this disease increases with age. In the presented work, for the first time, the age-related changes of Al, As, B, Ba, Bi, Cd, Ce, Cr, Cu, La, Li, Mg, Mn, Nb, Ni, Pb, Rb, Sb, Sn, Sr, Ti, W, and Zn content in the mammary gland of women aged 16–60 years was investigated. For this purpose, a method based on inductively coupled plasma mass spectrometry (ICP-MS) was employed, which makes it possible to determine the mass fractions of these trace elements in microsamples (mass from 10 mg) of breast tissue. With the help of this method, the material obtained during the autopsy of 38 practically healthy women aged 16–60 years who died suddenly was studied. Trace element mass fractions were determined in two age groups of women: 16–40 and 41–60 years old. Using the parametric Student's t-test and the non-parametric Wilcoxon-Mann-Whitney U-test to compare two age groups, as well as Pearson's correlation coefficients between age and trace elements mass fractions, it was found that the Cu, Mg, Rb, and Zn mass fractions in normal breast tissue decrease with age, while the As mass fraction increase. The phenomenon of the age-related changes of trace elements mass fractions in the normal mammary gland, discovered for the first time, requires further detailed study.

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"Comparison of Calcium, Chlorine, Iodine, Potassium, Magnesium, Manganese, and Sodium in Thyroid Tissue Adjacent to Thyroid Malignant and Benign Nodules"

Cited by 6 publications

References 36 publications

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Contents of twelve chemical elements in normal human breast determined using inductively coupled plasma atomic emission spectrometry

Age-related changes of trace element contents in normal human breast investigated using inductively coupled plasma mass spectrometry

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