Comparison of caffeine-induced locomotor activity between adolescent and adult rats

Marin, Marcelo Tadeu; Zancheta, Roberta; Paro, Ana Helena; Possi, Ana P. M.; Cruz, Fábio C.; Planeta, Cleópatra da Silva

doi:10.1016/j.ejphar.2011.03.052

Cited by 48 publications

(37 citation statements)

References 34 publications

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“…However, animal models, which offer the possibility of controlled longitudinal studies, are bringing a completely different picture. First, in adolescent rats, the acute psychomotor activating effects of caffeine are stronger and its depressant effects (with higher doses) milder than in adult rats, suggesting than adolescents can consume higher amounts (Marin et al 2011). Second, after chronic treatment with caffeine, both tolerance to the acute psychomotor activating effects and withdrawal-induced psychomotor depression were significantly more pronounced in adolescent rats, suggesting that adolescents can be more dependent on caffeine (withdrawal reversal) than the adult population (Rhoads et al 2011).…”

Section: The Real Danger: Caffeine Potentiates the Addictive And Toximentioning

confidence: 99%

Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders

2016

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Background The psychostimulant properties of caffeine are reviewed and compared with those of prototypical psychostimulants, able to cause substance use disorders (SUD). Caffeine produces psychomotor activating, reinforcing and arousing effects, which depend on its ability to disinhibit the brake that endogenous adenosine imposes on the ascending dopamine and arousal systems. Objectives A model that considers the striatal adenosine A2A-dopamine D2 receptor heteromer as a key modulator of dopamine-dependent striatal functions (reward-oriented behavior and learning of stimulus-reward and reward-response associations) is introduced, which should explain most of the psychomotor and reinforcing effects of caffeine. Highlights The model can explain the caffeine-induced rotational behavior in rats with unilateral striatal dopamine denervation and the ability of caffeine to reverse the adipsic-aphagic syndrome in dopamine-deficient rodents. The model can also explain the weaker reinforcing effects and low abuse liability of caffeine, compared with prototypical psychostimulants. Finally the model can explain the actual major societal dangers of caffeine: the ability of caffeine to potentiate the addictive and toxic effects of drugs of abuse, with the particularly alarming associations of caffeine (as adulterant) with cocaine, amphetamine derivatives and synthetic cathinones and energy drinks with alcohol; and the higher sensitivity of children and adolescents to the psychostimulants effects of caffeine and its possible increase in the vulnerability to develop SUD. Conclusions The striatal A2A-D2 receptor heteromer constitutes an unequivocal main pharmacological target of caffeine and provides the main mechanisms by which caffeine potentiates the acute and long-term effects of prototypical psychostimulants.

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Section: The Real Danger: Caffeine Potentiates the Addictive And Toximentioning

confidence: 99%

Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders

2016

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“…It is known that adolescents respond differently to caffeine compared with adults. For example, adolescent rats are more sensitive to caffeine given they exhibit higher locomotor activation to caffeine compared with adults (Marin et al, 2011). Chronic caffeine consumption produces tolerance to caffeine to a greater extent in adolescents compared with adults, suggesting that adolescent animals may exhibit greater brain changes associated with chronic caffeine consumption (Rhoads et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

O’Neill

Levis

Schreiner

et al. 2014

Neuropsychopharmacol

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Caffeine is the most commonly used psychoactive substance, and consumption by adolescents has risen markedly in recent years. We identified the effects of adolescent caffeine consumption on cocaine sensitivity and determined neurobiological changes within the nucleus accumbens (NAc) that may underlie caffeine-induced hypersensitivity to cocaine. Male Sprague-Dawley rats consumed caffeine (0.3 g/l) or water for 28 days during adolescence (postnatal day 28-55; P28-P55) or adulthood (P67-P94). Testing occurred in the absence of caffeine during adulthood (P62-82 or P101-121). Cocaine-induced and quinpirole (D 2 receptor agonist)-induced locomotion was enhanced in rats that consumed caffeine during adolescence. Adolescent consumption of caffeine also enhanced the development of a conditioned place preference at a sub-threshold dose of cocaine (7.5 mg/kg, i.p.). These behavioral changes were not observed in adults consuming caffeine for an equivalent period of time. Sucrose preferences were not altered in rats that consumed caffeine during adolescence, suggesting there are no differences in natural reward. Caffeine consumption during adolescence reduced basal dopamine levels and augmented dopamine release in the NAc in response to cocaine (5 mg/kg, i.p.). Caffeine consumption during adolescence also increased the expression of the dopamine D 2 receptor, dopamine transporter, and adenosine A 1 receptor and decreased adenosine A 2A receptor expression in the NAc. Consumption of caffeine during adulthood increased adenosine A 1 receptor expression in the NAc, but no other protein expression changes were observed. Together these findings suggest that caffeine consumption during adolescence produced changes in the NAc that are evident in adulthood and may contribute to increases in cocaine-mediated behaviors.

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“…Currently, existing nonprescription medications, energy drinks and supplements that contain caffeine add further opportunities for people to consume caffeine as an ergogenic (work-enhancing) aid [6]. In rats, the psychostimulant effect of caffeine can easily be assessed by measuring locomotor activity, which is increased in response to the administration of small to moderate doses of this drug [17,27,44].…”

Section: Introductionmentioning

confidence: 99%

Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context

Zancheta¹,

Possi²,

Planeta³

et al. 2012

Pharmacological Reports

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Abstract:Caffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects.

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Comparison of caffeine-induced locomotor activity between adolescent and adult rats

Cited by 48 publications

References 34 publications

Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders

Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context

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