Comparison of C-reactive protein and procalcitonin as predictors of postoperative infectious complications after elective colorectal surgery

Oberhofer, Dagmar; Juras, Josip; Pavičić, Ana Marija; Zuric, I.; Rumenjak, Vlatko

doi:10.3325/cmj.2012.53.612

Cited by 74 publications

(60 citation statements)

References 29 publications

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“…Similar observations were noted in colorectal surgery [27, 28]. In our study the patient who had signs on the 6 th POD did not have a significantly elevated PCT level on the 1 st and 2 nd POD.…”

Section: Discussionsupporting

confidence: 90%

Clinical evaluation of C-reactive protein and procalcitonin for the early detection of postoperative complications after laparoscopic sleeve gastrectomy.

Frask¹,

Orłowski²,

Dowgiałło-Wnukiewicz

et al. 2017

Videosurgery and Other Miniinvasive Techniques

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IntroductionAmong the most common early complications after bariatric surgery are anastomosis leak and bleeding. In order to react quickly and perform accurate treatment before the clinical signs appear, early predictors should be found. In the study C-reactive protein (CRP) and procalcitonin (PCT) levels were investigated. Characterized by a relatively short half-life, they can predict surgical complications.AimTo develop and implement certain standards for early detection of complications.Material and methodsThe study involved 319 adults who underwent laparoscopic sleeve gastrectomy (LSG) as a surgical intervention for morbid obesity at the Department of General Surgery of Ceynowa Hospital in Wejherowo. Every patient had CRP and PCT levels measured before the surgery and on the 1st and 2nd postoperative day (POD).ResultsEarly postoperative complications occurred in 19 (5.96%) patients. Septic and non-septic complications occurred in 3 and 16 patients respectively. Among the patients with septic postoperative complications CRP level increased significantly on the 2nd POD compared to the remainder (p = 0.0221). Among the patients with non-septic postoperative complications CRP level increased significantly on the 1st and 2nd POD compared to the remainder. Among the patients with septic and non-septic postoperative complications PCT level increased significantly on the 2nd POD compared to the remainder.ConclusionsThe CRP and PCT level are supposed to be relevant diagnostic markers to predict non-septic and septic complications after LSG.

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Section: Discussionsupporting

confidence: 90%

Clinical evaluation of C-reactive protein and procalcitonin for the early detection of postoperative complications after laparoscopic sleeve gastrectomy.

Frask¹,

Orłowski²,

Dowgiałło-Wnukiewicz

et al. 2017

Videosurgery and Other Miniinvasive Techniques

View full text Add to dashboard Cite

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“…These elevated levels after abdominal surgery could be attributed to the transient bacterial translocation from the gastrointestinal tract due to malperfusion of the gut [11]. Oberhofer et al [21] evaluated and compared the roles of perioperative CRP and PCT for the early detection of infective complications after colorectal surgery. They documented that the CRP level on POD 3 and PCT level on POD 2 had similar predictive values for the development of infectious complications, with the best cut-off values of 99.0 mg/L for CRP and 1.34 µg/L for PCT.…”

Section: Discussionmentioning

confidence: 99%

“…The cut-off value of PCT on POD 1 in their study was 1.1 ng/ml, with sensitivity of 81% and specificity of 72%. Previous studies reported that PCT is an accurate marker for the early diagnosis of postoperative infective complication [56721] and ventilator-associated pneumonia [8]. On the other hand, some studies concluded that PCT had no added benefit in the prediction of postoperative infection [23].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, some studies concluded that PCT had no added benefit in the prediction of postoperative infection [23]. Several studies have compared PCT and CRP for the diagnosis of postoperative infectious complications [52124], and PCT is documented to be more sensitive than CRP for the early detection of postoperative septic complications after major surgery in some previous studies [2225]. However, CRP was proven to be more sensitive than PCT in other studies [26].…”

Section: Discussionmentioning

confidence: 99%

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Value of procalcitonin as a biomarker for postoperative hospital-acquired pneumonia after abdominal surgery

Elyazed

Zaki

2017

Korean J Anesthesiol

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BackgroundHospital-acquired pneumonia (HAP) is a common complication after abdominal surgery. The aim of this study was to evaluate the role of procalcitonin (PCT) and C-reactive protein (CRP) as early biomarkers for the diagnosis of postoperative HAP after abdominal surgery.MethodsThis study was conducted on 100 patients undergoing abdominal surgery. White blood cell counts, highest body temperature, and serum levels of CRP and PCT were recorded preoperatively and daily postoperatively until postoperative day (POD) 5. Chest radiography was performed preoperatively and daily postoperatively until POD 5.ResultsHAP was diagnosed in 14% of patients. Regarding the biomarkers studied after POD 1, CRP and PCT were significantly higher in patients with HAP than in those without HAP (P < 0.05). On POD 2, PCT had higher sensitivity and specificity (84% and 72%, respectively) than those for CPR (70% and 60%, respectively). The cut-off value of PCT on POD 2 was 1.4 ng/ml. On POD 3, 4, and 5, the sensitivity and specificity of PCT and CRP were not significantly different.ConclusionsPCT and CRP are accurate biomarkers for early prediction of postoperative HAP after abdominal surgery. The diagnostic ability of PCT was significantly better than that of CRP on POD 2. After POD 2, the diagnostic ability was not significantly different between the biomarkers.

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“…Suppression of tumour-specific CD4+ T cells by The question is, how to diagnose potentially septic complication early (before clinical symptomatology). Some study showed that C reactive protein and/or procalcitonin are useful biochemical markers that could accurately differentiate between infectious and noninfectious complications (19,20).…”

Section: Grades Definitionmentioning

confidence: 99%

Impact of Postoperative Septic Complications on Recurrence of Colorectal Cancer

Levý¹,

Lipská²,

Sojka³

et al. 2017

SGO

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Background: About one third of patients racically resected for colorectal cancer develop during follow-up recurrence. Materials and methods: There were 1951 patients operated for colorectal cancer in Surgical Department, Thomayer Hospital Prague, from 1997 to 2015. Radical R0 operation underwent 68% of these patients. Postoperative complications occurred in 457 (34.6%) patients. Impact of postoperative complications on disease free interval was studied in a prospective study. Results: We identified minor complications in 90 patients (6.8%), moderate complications in 28 patients (2.1%), anastomotic leakage in 67 patients (5%) and severe septic complications in 20 patients (1.5%). Another 255 patients (19.3%) had a different, non-inflammatory complications (pulmonary embolism, bowel obstruction, heart failure, etc.). Significantly worse disease-free interval was found in patients with severe septic complications. Conclusion: In our cohort of R0 operated patients, postoperative complication is the second most important prognostic factor following TNM stage of the colorectal cancer. Severe septic complications has an adverse effect on the further course of the disease in terms of relapse. Other potentially septic complications such as anastomotic leakage have no essential impact on recurrence. Therefore, it is necessary to prevent the development of sepsis.

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Comparison of C-reactive protein and procalcitonin as predictors of postoperative infectious complications after elective colorectal surgery

Cited by 74 publications

References 29 publications

Clinical evaluation of C-reactive protein and procalcitonin for the early detection of postoperative complications after laparoscopic sleeve gastrectomy.

Clinical evaluation of C-reactive protein and procalcitonin for the early detection of postoperative complications after laparoscopic sleeve gastrectomy.

Value of procalcitonin as a biomarker for postoperative hospital-acquired pneumonia after abdominal surgery

Impact of Postoperative Septic Complications on Recurrence of Colorectal Cancer

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