Comparison of burn and incision wound healing in rat given crude extract of porcupine quill (Hystrix sp)

Abstract

Delayed and impaired wound healing in burn and incisional wound can lead to scarring and may cause considerable distress to patients. In line with Sustainable Development Goal (SDG) particularly SDG no 3, the study of finding materials that accelerate skin wound healing and minimize the scarring of the wound became important field of study. In some regions in Indonesia, porcupine quills are used as a traditional medicine to heal wound and relieve pain by the traditional community. Therefore, this study aims to evaluate the comparison between burn and incisional wound healing in rat using crude extract of porcupine quills as the natural compound. The results showed that crude extract of porcupine quills in gel base had positive effect on burn and incisional wound healing compared to those without treatment or in cream base. In addition, the crude extract of porcupine quills in gel base decreased the mortality rate in burn wounded rats, increased body weight, and contributed in quicker wound closure in burn and incisional wounded rats. Incisional wound closed quicker than in burn wound indicated by skin closure and full re-epithelization histologically. The burn wound healed more than 21 days, however, the administration crude extract of porcupine quills in gel base results in comparable rate of wound closure compared to commercial product. These findings indicated that crude extract of porcupine quill in gel base can improve the burn and incisional wound healing with less mortality.