Comparison of breast cancer and cervical cancer stage distributions in ten newly independent states of the former Soviet Union: a population-based study

Ryzhov, Anton; Corbex, Marilys; Piñeros, Marion; Барчук, Антон; Andreasyan, Diana; Djanklich, S.; Ghervas, Vadim; Грецова, О. П.; Kaidarova, Dilyara; Kazanjan, Konstantin; Mardanli, Fuad A. ogly; Michailovich, Yuriy; Ten, Elena; Yaumenenka, Alesya; Bray, Freddie; Znaor, Ariana

doi:10.1016/s1470-2045(20)30674-4

Cited by 29 publications

(28 citation statements)

References 13 publications

(19 reference statements)

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“…In terms of early detection, the traditions of opportunistic screening for different cancer sites in broad age groups at the level of primary care (dispensaries and/or policlinics) frequently by non-standard methods tend to be upheld across the region. 28 Breast cancer remains the leading cause of cancer death in the NIS among women, followed by colorectal and cervical cancer. We have recently documented the later stage at diagnosis of both breast and cervical cancer in the NIS compared with EU countries, as well as the rising trend in cervical cancer incidence.…”

Section: Discussionmentioning

confidence: 99%

Progress in reducing premature mortality from cancer and cardiovascular disease in the former Soviet Union, 2000–19

Znaor

Corbex

Cao

et al. 2022

European Journal of Public Health

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Background A reduction in non-communicable diseases premature mortality by one-third by 2030 is one of the targets of the UN Sustainable Development Goals (SDG3.4). We examined the mortality profiles in the Newly Independent States of the former Soviet Union (NIS) and the European Union (EU) and assessed progress in reductions of premature mortality from cancer, as compared to cardiovascular disease (CVD). Methods We used WHO’s Global Health Estimates and GLOBOCAN 2020 to examine current mortality profiles and computed the unconditional probabilities of dying at ages 30–70 from CVD and cancer for the years 2000–19 in both sexes, using a linear extrapolation of this trend to predict whether the target of a one-third reduction, as set in 2015, would be met in 2030. Results CVD was the main cause of premature death in the NIS (43%), followed by cancer (23%), inversely from the EU with 42% cancer and 24% CVD deaths. The NIS achieved major reductions in premature CVD mortality, although the probabilities of death in 2019 remained about five times higher in the NIS compared to the EU. For cancer, mortality reductions in most NIS were quite modest, other than large declines seen in Kazakhstan (44%) and Kyrgyzstan (30%), with both on course to meet the 2030 target. Conclusions Limited progress in cancer control in the NIS calls for policy action both in terms of structural changes towards universal health coverage, and scaling up of national cancer control plans, including a shift from opportunistic to evidence-based early detection practices.

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Section: Discussionmentioning

confidence: 99%

Progress in reducing premature mortality from cancer and cardiovascular disease in the former Soviet Union, 2000–19

Znaor

Corbex

Cao

et al. 2022

European Journal of Public Health

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“…The contrasting trends in mortality from stomach and colon cancers described in Moldova and other developed countries refer to the changes in traditions of food preparation and eating habits. Thus, declining mortality from stomach cancer is closely associated with the increased food variety in a diet, while the rise in mortality from cancer of the intestine is positively correlated with the consumption of meat and animal fat (24). In Moldova, as in other countries of the FSU, this phenomenon has showed an enormous delay compared to Western countries.…”

Section: Discussionmentioning

confidence: 99%

Long-term trends in cancer mortality in the Republic of Moldova

Penina¹

2021

OH&RM

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Introduction. Cancer is the second cause-of-death mortality pattern in the Republic of Moldova. The study of both cancer mortality by age and its detailed causes is an important tool for evidence-based public health policy. The study aims at comparing recent changes in cancer mortality with long-term trends, depending on specific causes and age. Material and methods. This study was carried out on the reconstructed 1965-2018 death time series, according to the 10th revision of the International Classification of Diseases. Standardized death rates were computed. Results. After a gradual increase in the ‘70s and ‘80s of the last century, cancer mortality rate showed “reversed” patterns and started to decline in the ‘90s. This decline was due to the data quality issue and to the competing risks of dying from other causes sensitive to the social and economic circumstances of the ‘90s. Since the beginning of the millennium, cancer mortality has resumed its growth that continues up to now. Despite the increasing overall trend in cancer mortality rate during 1965-2018, the analysis by age and specific causes revealed opposite trends. Conclusions. The malignant neoplasms specific for certain sites and age groups (stomach, uterus, leukaemia in children) showed, however some therapeutic progress, while the situation for other tumour sites (lung, breast, and intestine) worsened significantly. The moderate decrease in lung cancer in the 1990s should be cautiously interpreted.

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“…It is well known that human papillomavirus (HPV), particularly HPV16 and HPV18, is the main etiological factor of cervical carcinoma ( 3 , 4 ). Although HPV vaccines are effective against HPV-related cervical cancer, and early screening can reduce the mortality of cervical cancer, most patients are already at an advanced stage at the time of diagnosis ( 5 ). For metastatic cervical cancer, the prognosis is poor, with a mean survival period of only eight to thirteen months ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis

Lü

Wang

et al. 2022

Front. Oncol.

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BackgroundA number of studies have demonstrated that circular RNA (circRNA) plays a critical role in tumorigenesis and tumor progression. However, the biological effects of most circRNAs on cervical cancer remain unclear. Hsa_circ_0021087 (thereafter named circLMO1) is a circRNA generated from the circularization of exon 2 and exon 3 of LIM Domain Only 1 (LMO1) and first identified as a tumor suppressor in gastric cancer. We aimed to identify the role of circLMO1 in cervical cancer progression.MethodsCircLMO1 was verified through qPCR and Sanger sequencing. The biological role of circLMO1 in regulating cervical cancer growth and metastasis was investigated both in vitro and in the nude mouse xenograft tumor model. The dual luciferase reporter assay and rescue experiment were conducted to evaluate the interactions among circLMO1, microRNA (miR)-4291, and acyl-CoA synthetase long chain family member 4 (ACSL4). The role of circLMO1 in regulating ferroptosis was assessed by analyzing lipid reactive oxygen species (ROS), and malonyl dialdehyde (MDA), and glutathione (GSH) content.ResultsThe level of circLMO1 was down-regulated in cervical cancer tissues and was associated with the International Federation of Gynecology and Obstetrics (FIGO) staging. Functionally, circLMO1 overexpression inhibited cervical cancer growth and metastasis both in vitro and in vivo, whereas circLMO1 depletion promoted cervical cancer cell proliferation and invasion. Mechanistically, circLMO1 acted as a competing endogenous RNA (ceRNA) by sponging miR-4192 to repress target gene ACSL4. CircLMO1 promoted cervical cancer cell ferroptosis through up-regulating ACSL4 expression. Overexpression of miR-4291 or knockdown of ACSL4 reversed the effect of circLMO1 on facilitating ferroptosis and repressing cervical cancer cell proliferation and invasion.ConclusionCircLMO1 acted as a tumor suppressor of cervical cancer by regulating miR-4291/ACSL4-mediated ferroptosis, and could be a promising biomarker for the clinical management of cervical cancer.

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Comparison of breast cancer and cervical cancer stage distributions in ten newly independent states of the former Soviet Union: a population-based study

Cited by 29 publications

References 13 publications

Progress in reducing premature mortality from cancer and cardiovascular disease in the former Soviet Union, 2000–19

Progress in reducing premature mortality from cancer and cardiovascular disease in the former Soviet Union, 2000–19

Long-term trends in cancer mortality in the Republic of Moldova

Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis

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