Comparison of Bovine Immune Responses to Affinity-Purified Bovine Herpesvirus-1 Antiidiotypes and Glycoproteins

Orten, Dana J.; Xue, Wei; Hurk, Sylvia van Drunen Littel‐van den; Abdelmagid, O.Y.; Reddy, D. Nageshwar; Campos, Manuel; Babiuk, L A; Blecha, Frank; Minocha, H.C.

doi:10.1089/vim.1993.6.109

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Srikumaran et al (1990), Hariharan et al (1991), and Orten et al (1991) used neutralizing murine MAb as Ab1 to generate bovine polyclonal Ab (PAb), bovine MAb, or rabbit PAb Ab2 respectively, which in turn were used to elicit neutralizing Ab3 in mice. Orten et al (1993) immunized calves with an Ab2 (rabbit PAb anti-Id to murine anti-gB and gD MAb), resulting in a slight reduction of clinical signs and one calf producing BHV-1-neutralizing antibodies.…”

Section: Anti-idiotypementioning

confidence: 99%

Immunity to bovine herpesvirus 1: II. Adaptive immunity and vaccinology

Levings

Roth

2013

Anim. Health. Res. Rev.

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Bovine herpesvirus 1 (BHV-1) infection is widespread and causes a variety of diseases. Although similar in many respects to the human immune response to human herpesvirus 1, the differences in the bovine virus proteins, immune system components and strategies, physiology, and lifestyle mean the bovine immune response to BHV-1 is unique. The innate immune system initially responds to infection, and primes a balanced adaptive immune response. Cell-mediated immunity, including cytotoxic T lymphocyte killing of infected cells, is critical to recovery from infection. Humoral immunity, including neutralizing antibody and antibodydependent cell-mediated cytotoxicity, is important to prevention or control of (re-)infection. BHV-1 immune evasion strategies include suppression of major histocompatibility complex presentation of viral antigen, helper T-cell killing, and latency. Immune suppression caused by the virus potentiates secondary infections and contributes to the costly bovine respiratory disease complex. Vaccination against BHV-1 is widely practiced. The many vaccines reported include replicating and non-replicating, conventional and genetically engineered, as well as marker and non-marker preparations. Current development focuses on delivery of major BHV-1 glycoproteins to elicit a balanced, protective immune response, while excluding serologic markers and virulence or other undesirable factors. In North America, vaccines are used to prevent or reduce clinical signs, whereas in some European Union countries marker vaccines have been employed in the eradication of BHV-1 disease. AbstractBovine herpesvirus 1 (BHV-1) infection is widespread and causes a variety of diseases.

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Section: Anti-idiotypementioning

confidence: 99%

Immunity to bovine herpesvirus 1: II. Adaptive immunity and vaccinology

Levings

Roth

2013

Anim. Health. Res. Rev.

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Generation and characterization of virus-neutralizing bovine monoclonal antibodies to bovine herpesvirus 1 glycoproteins gB, gC, and gD

Levings

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Three bovine monoclonal antibodies (MAb) which neutralized bovine herpesvirus 1 (BHV1) were generated using a unique 'self-refusion' method. Each was determined to be directed to one of the three major neutralization targets of BHV1 (gB, gC, and gD), and was capable of passive immunization in a laboratory rabbit intravenous challenge model. They were found to be specific for the immunizing BHV1 or for BHV1 and the closely related BHV5. The epitope specificities of two were identified using characterized murine MAb. The previously unidentified combination of epitope and virus reactivity of the two bovine MAb suggest a sequence-structural difference in gB between BHV1.1 and BHV5, and an epitope adjacent to a known epitope for the anti-gD bovine MAb. Anti-idiotypic antibodies were generated against one of the bovine MAb for possible use in vaccination. Bovine MAb may offer unique advantages for research and application in diagnostics, vaccine development, and in better understanding the bovine immune response to infectious disease. CHAPTER 2. IMMUNOLOGY OF BOVINE HERPESVIRUS INFECTION

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Comparison of Bovine Immune Responses to Affinity-Purified Bovine Herpesvirus-1 Antiidiotypes and Glycoproteins

Cited by 2 publications

References 31 publications

Immunity to bovine herpesvirus 1: II. Adaptive immunity and vaccinology

Immunity to bovine herpesvirus 1: II. Adaptive immunity and vaccinology

Generation and characterization of virus-neutralizing bovine monoclonal antibodies to bovine herpesvirus 1 glycoproteins gB, gC, and gD

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