Comparison of Bovine Bone-Autogenic Bone Mixture Versus Platelet-Rich Fibrin for Maxillary Sinus Grafting: Histologic and Histomorphologic Study

Abstract

Numerous grafting materials have been used to augment the maxillary sinus floor for long-term stability and success for implant-supported prosthesis. To enhance bone formation, adjunctive blood-born growth factor sources have gained popularity during the recent years. The present study compared the use of platelet-rich fibrin (PRF) and bovine-autogenous bone mixture for maxillary sinus floor elevation. A split-face model was used to apply 2 different filling materials for maxillary sinus floor elevation in 22 healthy adult sheep. In group 1, bovine and autogenous bone mixture; and in group 2, PRF was used. The animals were killed at 3, 6, and 9 months. Histologic and histomorphologic examinations revealed new bone formation in group 1 at the third and sixth months. In group 2, new bone formation was observed only at the sixth month, and residual PRF remnants were identified. At the ninth month, host bone and new bone could not be distinguished from each other in group 1, and bone formation was found to be proceeding in group 2. PRF remnants still existed at the ninth month. In conclusion, bovine bone and autogenous bone mixture is superior to PRF as a grafting material in sinus-lifting procedures.

Evaluation of L‐PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial

“…Importantly, the maturation of this type of material may take up to 8 months before implants can be safely placed in maxillary sinus, which might be considered a disadvantage of this material. To mitigate this shortcoming, the addition of growth factors, particularly L‐PRF, to the graft material has been suggested as an alternative approach to increase bone formation, enhance implant stability, favor osseointegration, and accelerate tissue maturation and healing …”

“…To mitigate this shortcoming, the addition of growth factors, particularly L-PRF, to the graft material has been suggested as an alternative approach to increase bone formation, enhance implant stability, favor osseointegration, and accelerate tissue maturation and healing. 1,18,21,22,[28][29][30]34,35,44,45,[47][48][49][50][51][52] CBCT is considered a reliable technique for the 3D visualization of graft volume changes after sinus augmentation. In this study, we performed three different CBCTs at different time points: immediately after the bone graft, and after 4 and 8 months of healing.…”

“…To overcome this concern, several studies have investigated the addition of growth factors to grafting material aiming at enhance bone neoformation and accelerates graft maturation. 1,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Leukocyte and platelet-rich fibrin (L-PRF), first described by Dohan and colleagues 33 is an autogenous biomaterial containing several growth factors. 1,18,19,25 L-PRF, a second-generation of platelet concentrates, is basically made of concentrated autologous platelets as well as leukocytes and cytokines.…”

The use of bioactive factors to enhance bone regeneration: A narrative review

“…In rabbits, sinus floor augmentation combining PRF with DBM or collagenated heterologous bone did not result in any benefit in terms of bone regeneration (Peker, Karaca & Yildirim, ). Moreover, in sheep a mixture of bovine and autologous bone performed better than PRF, as confirmed by histomorphometry findings (Ocak, Kutuk, Demetoglu, Balcioglu & Ozdamar, )…”

Platelet Rich Fibrin in Periodontal Practice, Review

“…In group 1, bovine and autogenous bone mixture; and in group 2, PRF was used. The results of this study showed that bovine bone and autogenous bone mixture is superior to PRF as a grafting material in sinus-lifting procedures [34]. According to the results of this study, it may be suggested that PRF should not be used alone in sinus-lift procedure.…”