Comparison of Boric Acid and Combination Drug of Polymyxin, Neomycin and Hydrocortisone (polymyxin NH) in the Treatment of Acute Otitis Externa

Amani, Soroush; Moeini, Mohammad

doi:10.7860/jcdr/2016/17175.8073

Cited by 8 publications

(16 citation statements)

References 9 publications

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“…External otitis, frequently due to Pseudomonas , may also be cured by the topical use of the drug. P. aeruginosa is a common cause of infection of corneal ulcers; the local application or subconjunctival injection of polymyxin B is often curative [ 50 ].…”

Section: Clinically Useful Polymyxins and Their Principle Propertimentioning

confidence: 99%

Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance

2020

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Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the rising global prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria have both rejuvenated clinical interest in these polypeptide antibiotics. Parallel to the revival of their use, investigations into the mechanisms of action and resistance to polymyxins have intensified. With an initial known effect on biological membranes, research has uncovered the detailed molecular and chemical interactions that polymyxins have with Gram-negative outer membranes and lipopolysaccharide structure. In addition, genetic and epidemiological studies have revealed the basis of resistance to these agents. Nowadays, resistance to polymyxins in MDR Gram-negative pathogens is well elucidated, with chromosomal as well as plasmid-encoded, transferrable pathways. The aims of the current review are to highlight the important chemical, microbiological, and pharmacological properties of polymyxins, to discuss their mechanistic effects on bacterial membranes, and to revise the current knowledge about Gram-negative acquired resistance to these agents. Finally, recent research, directed towards new perspectives for improving these old agents utilized in the 21st century, to combat drug-resistant pathogens, is summarized.

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Section: Clinically Useful Polymyxins and Their Principle Propertimentioning

confidence: 99%

Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance

2020

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“…Type of discharge can help in identification of the causative organism such as Candida produces white cheesy discharge while Pseudomonas forms green foul smelling discharge. 16,17 Multiple treatment options exist for management of otitis externa depending upon its severity and the preference of the treating physician. A thorough suction clearance of the external auditory canal for discharge and debris ensures quick and effective relief whichever mode of treatment is selected.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Efficacy of Antibiotic-Steroid and Ichthammol Glycerine Wick in Treatment of Acute Otitis Externa

Khan

Butt

Riaz

et al. 2021

PAFMJ

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Objective: To compare the efficacy of steroid antibiotic wick with Ichthammol Glycerol wick in the management of Acute Otitis Externa in terms of tenderness and clearance of discharge/debris. Study Design: Quasi-experimental study. Place and Duration of Study: ENT Out Patient department of Combined Military Hospital Peshawar and Hayatabad Medical Complex Peshawar, from May to Nov 2018. Methodology: A total of 250 patients were included and divided into two groups of 125 each. After necessary suction clearance topical Ciprofloxacin/Dexamethasone (Cipotec-D) wick was placed in auditory canal of group A patients and topical Glycerol/Ichthammol wick was placed in group B. Follow up visits were done on 3rd and 7th day of starting the treatment. Results: Group A patients responded better in terms of tenderness (88%) however both groups had similar response in terms of discharge reduction (7.2% vs 6.4%). In terms of efficacy neither of the treatment proved more efficacious compared to the other (p-value 0.058). Conclusion: While steroid antibiotic wick is significantly more efficient in terms reducing tenderness, in terms of overall efficacy and discharge reduction Ichthammol/glycerol is equally effective.

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“…An argument opposed the prescribing oral antibiotics for acute OE is the effectiveness of topical agents that do not contain antibiotics. Boric acid, acetic acid, and aluminum acetate are effective topical solutions as a single agent [21,22]. A randomized multicenter trial also found no significant differences in bacteriologic efficacy or pain duration between topical treatment and topical treatment combined with oral amoxicilin [20].…”

Section: Systemic Antimicrobialsmentioning

confidence: 99%

Pediatric Otitis Externa

Aladağ

İmre

Karpishchenko

2021

Pediatric ENT Infections

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Comparison of Boric Acid and Combination Drug of Polymyxin, Neomycin and Hydrocortisone (polymyxin NH) in the Treatment of Acute Otitis Externa

Cited by 8 publications

References 9 publications

Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance

Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance

Comparison of the Efficacy of Antibiotic-Steroid and Ichthammol Glycerine Wick in Treatment of Acute Otitis Externa

Pediatric Otitis Externa

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