Comparison of bone apatite in osteoporotic and normal Eskimos

Thompson, David D.; Posner, Aaron S.; Laughlin, William S.; Blumenthal, Norman C.

doi:10.1007/bf02405064

Cited by 49 publications

(22 citation statements)

References 5 publications

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“…Differences in the material properties between osteoporotic and 'normal' material, particularly derived from X-ray diffraction, are not consistent across the literature [17,24,27,35,36].…”

Section: Discussionmentioning

confidence: 56%

“…Perhaps of most relevance are those reports detailing differences between osteoporotic and 'normal' tissues, although inconsistencies are frequent. For example, reports such as those of Thompson et al [17] and Faibish and Boskey [34] suggested an increase in crystallite size in osteoporotic tissue. However, these two reports differ in conclusions regarding the crystal chemistry;…”

Section: Introductionmentioning

confidence: 99%

“…Several previous studies have examined the physicochemical properties of the inorganic bone component (i.e. the hydroxyapatite mineral) characterised by X-ray diffraction (XRD) [17,24,25] and the organic component (i.e. collagen) as characterised by Raman spectroscopy [28,29] or Fourier transform infra-red spectroscopy (FTIR) [26, 30 -33].…”

Section: Introductionmentioning

confidence: 99%

“…Thompson suggested a decrease in carbonate [17], while Faibish and Boskey [34] argued for an increase when comparing osteoporotic to normal bone. An increase in both crystallite size and carbonate content was reported by Gadeleta et al [18].…”

Section: Introductionmentioning

confidence: 99%

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Towards new material biomarkers for fracture risk

Greenwood

Clement

Dicken

et al. 2016

Bone

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Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) using dual energy X-ray absorption (DEXA). However, the risk of osteoporotic fracture is determined collectively by bone mass, architecture and physicochemistry of the mineral composite building blocks. Thus DEXA scans alone inevitably fail to fully discriminate individuals who will suffer a fragility fracture. This study examines trabecular bone at both ultrastructure and microarchitectural levels to provide a detailed material view of bone, and therefore provides a more comprehensive explanation of osteoporotic fracture risk. Physicochemical characterisation obtained through X-ray diffraction and infrared analysis indicated significant differences in apatite crystal chemistry and nanostructure between fracture and non-fracture groups.Further, this study, through considering the potential correlations between the chemical biomarkers and microarchitectural properties of trabecular bone, has investigated the relationship between bone mechanical properties (e.g. fragility) and physicochemical material features.

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“…Differences in the material properties between osteoporotic and 'normal' material, particularly derived from X-ray diffraction, are not consistent across the literature [17,24,27,35,36].…”

Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Towards new material biomarkers for fracture risk

Greenwood

Clement

Dicken

et al. 2016

Bone

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“…Other studies have also examined bone loss in archaeological Arctic material with bone core analysis, whereby photon-absorptiometry, histomorphometry, and measures of cortical thickness are performed on a bone core that is sampled from the femoral midshaft (Laughlin et al, 1979;Thompson et al, 1981). Bone core studies of different archaeological Inuit skeletons, when compared with U.S. whites, show thinner cortices, lower bone mineral content, and increased secondary osteonal remodeling, suggestive of an increase in intracortical porosity and subsequent bone loss (Thompson et al, 1981(Thompson et al, , 1983Thompson and Gunness-Hey, 1981). Yet another geographic area in which archaeological bone mass is extensively examined is Sudanese Nubia.…”

Section: Bone Mass In Fast Populationsmentioning

confidence: 96%

Bone quantity and quality in past populations

Agarwal

Grynpas

1996

Anat. Rec.

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Osteoblast precursor cell activity on HA surfaces of different treatments

Ong

Hoppe

Cardenas

et al. 1998

J. Biomed. Mater. Res.

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The clinical success of dental implants is governed by implant surfaces and bone cell responses that promote rapid osseointegration and long-term stability. The specific objective of this study was to investigate osteoblast precursor cell responses to hydroxyapatite (HA) surfaces of different treatments. Since the nature of bone cell responses in vitro is influenced by the properties of HA ceramics, this study was divided into two components: a chemical and crystallographic characterization of the HA ceramics and an in vitro cell culture study. The sintered HA samples were observed to have the highest crystallite size as compared to the as-received HA and calcined HA samples. No differences in the surface roughness and chemical composition were observed among the sintered, calcined, and as-received HA surfaces. In concurrence with the X-ray diffraction, high resolution XPS resolution of Ca 2p also indicated a higher crystallinity on sintered HA samples as compared to the calcined and as-received HA samples. As indicated by increased alkaline phosphatase-specific activity, increased cell-surface and matrix-associated protein, and 1.25 (OH2) vitamin D3-stimulated osteocalcin production, a more differentiated osteoblast-like phenotype was observed on the sintered HA surfaces compared to the as-received HA and calcined HA surfaces. An increased osteoblast-like cell activity on the sintered HA surfaces suggested that the crystallite size of HA surfaces may play an important role in governing cellular response.

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Comparison of bone apatite in osteoporotic and normal Eskimos

Abstract: An infrared and x-ray diffraction study of osteoporotic and normal, archaeological Eskimo bones. Osteoporotic bone apatite is greater in crystal size and/or perfection and lower in CO3 than normal bone apatite.

Cited by 49 publications

References 5 publications

Towards new material biomarkers for fracture risk

Towards new material biomarkers for fracture risk

Bone quantity and quality in past populations

Osteoblast precursor cell activity on HA surfaces of different treatments

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