Comparison of biological efficiency of accelerated carbon ions and heavy recoils in Chinese hamster cells

Koryakina, E. V.; Potetnya, V. I.; Troshina, Marina; Efimova, M.N.; Baykuzina, R.M.; Koryakin, Sergey; Lychagin, Anatoly; Pikalov, V. A.; Ul'yanenko, S. E.

doi:10.21870/0131-3878-2019-28-3-96-106

Cited by 7 publications

(2 citation statements)

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“…This requires addressing a range of radiobiological problems (Markov et al 2016). Accelerator-based radiation monitoring and radiobiological studies were undertaken, and the relative biological effectiveness (RBE) and the linear energy transfer (LET) were estimated for the Bragg plateau, Bragg peak and tail carbon ions (Pikalov et al 2018, Koryakina et al 2019). The experimental data on the action of carbon ions on the HeLa tumor cells presented in this paper agree well with the data in (Lipengolts et al 2009, Troshina et al 2020) obtained for neoplastic and non-neoplastic cells of different origin.…”

Section: Discussionmentioning

confidence: 99%

Synergetic effects of the combined action of carbon ions and the chemotherapy drug doxorubicin on HeLa cancer cells

Komarova¹,

Melnikova²,

Baldov³

2021

NUCET

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Proton and carbon beam therapy is currently recognized as the most effective and highly accurate form of radiation therapy for deeply located tumors, including radioresistant ones. This is due to the fact that they have all the advantages of spatial dose distribution and, at the same time, are densely ionizing radiations capable of effectively affecting hypoxic, slow-growing tumors and other neoplasms that are insensitive to traditional types of radiation. It is well known that one of the main methods for treating neoplasms is chemotherapy. The predominant mechanism of action of anti-tumor drugs is the induction of DNA damage with the subsequent impossibility of repair. In our study, we used an anti-tumor antibiotic of the anthracycline series, doxorubicin. The assessment of the potential significance of the synergistic interaction of ionizing radiation with chemical preparations in medical radiology remains an urgent and unresolved problem. It is possible to achieve the maximum effect of the combined action of two agents when they act simultaneously. The phenomenon of synergy can be used to optimize the combined use of radiation and chemotherapy in clinical practice. In this regard, it seems relevant to conduct a study for HeLa cancer cells exposed to ionizing radiation, an antitumor drug, as well as their combination. In the course of the study, results were obtained on the manifestation of the synergistic nature of the agents used, which is of great practical and theoretical importance for understanding the mechanism of the combined effect of ionizing radiation and the chemotherapy drug (doxorubicin). The obtained data can be helpful in optimizing the combined effects in order to achieve maximum synergistic interaction.

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Section: Discussionmentioning

confidence: 99%

Synergetic effects of the combined action of carbon ions and the chemotherapy drug doxorubicin on HeLa cancer cells

Komarova¹,

Melnikova²,

Baldov³

2021

NUCET

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“…Cells were irradiated at the proximal (a depth of ~10 cm in a water phantom, LET d ~10–12 keV/μm) and the distal region of the pristine Bragg curve (~1 cm behind the Bragg peak, LET d ~25–27 keV/μm) in the dose range of 0.05–2.5 Gy. Physical and dosimetry studies were published elsewhere [ 50 , 51 , 52 ].…”

Section: Methodsmentioning

confidence: 99%

Hypersensitivity and Induced Radioresistance in Chinese Hamster Cells Exposed to Radiations with Different LET Values

Koryakina

Potetnya

Troshina

et al. 2022

IJMS

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We study the impact of radiation LET on manifestation of HRS/IRR response in Chinese hamster cells ovary cells exposed to radiations used in radiotherapy. Earlier we have investigated this response to carbon ions (455 MeV/amu) in the pristine Bragg curve plateau and behind the Bragg peak, 60Co γ-rays, and 14.5 MeV neutrons. Now we present results of cytogenetic metaphase analysis in plateau-phase CHO-K1 cells irradiated with scanning beam protons (83 MeV) at doses < 1 Gy and additional data for 14.5 MeV neutrons. Dose curves for frequency of total chromosome aberrations (CA, protons), paired fragments (protons, neutrons), aberrant cells (neutrons) had typical HRS/IRR structure: HRS region (up to 0.1 and 0.15 Gy), IRR region (0.1–0.6 Gy and 0.15–0.35 Gy) for protons and neutrons, respectively, and regular dose dependence. Taken together with previous results, the data show that LET increase shifts the HRS upper border (from 0.08–0.1 Gy for γ-rays, protons and plateau carbons to 0.12–0.15 Gy for “tail” carbons and neutrons). The IRR regions shortens (0.52–0.4 γ-rays and protons, 0.25 plateau carbons, 0.2 Gy “tail” carbons and neutrons). CA level of IRR increases by 1.5–2.5 times for carbons as compared to γ-rays and protons. Outside HRS/IRR the yield of CA also enhanced with LET increase. The results obtained for different LET radiations suggest that CHO-K1 cells with G1-like CA manifested the general feature of the HRS/IRR phenomena.

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Dose Field Shaping and Biological Effectiveness of the Effect of Pulsed Electron Accelerator Novac-11 on Mammalian Cells

et al. 2022

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Comparison of biological efficiency of accelerated carbon ions and heavy recoils in Chinese hamster cells

Cited by 7 publications

References 0 publications

Synergetic effects of the combined action of carbon ions and the chemotherapy drug doxorubicin on HeLa cancer cells

Synergetic effects of the combined action of carbon ions and the chemotherapy drug doxorubicin on HeLa cancer cells

Hypersensitivity and Induced Radioresistance in Chinese Hamster Cells Exposed to Radiations with Different LET Values

Dose Field Shaping and Biological Effectiveness of the Effect of Pulsed Electron Accelerator Novac-11 on Mammalian Cells

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