Comparison of Biliary Leakage in Laparoscopic and Open Cholecystectomy

Abstract

BACKGROUND Laparoscopic surgery is unsafe and technically impossible in case a gall-bladder disease has changed the usual anatomic landmarks. Though, open cholecystectomy has fewer incidents of biliary leakage, the risk cannot be avoided. However, it seems that with adoption of preventive measures and requisite skills, the biliary leakage rate has been controlled in laparoscopic surgery. The study aimed to compare the frequency and cause of biliary leak between laparoscopic (LC) and open cholecystectomy (OC).

Synthesis and biological screening of some novel 6‐substituted 2‐alkylpyridazin‐3(2H)‐ones as anti‐inflammatory and analgesic agents

“…The pyridazin‐3‐one moiety has a diverse set of biological activities. A wide range of biological activities was recorded for pyridazine derivatives such as antiangiogenic, anticancer, antimicrobial, analgesic, antidepressant, antihypertensive, antifungal, antifeedant, phosphodiesterase‐4 (PDE4), inhibitors are effective anti‐inflammatory, selective COX‐2 inhibitors, and antiplatelet activities. Various drugs include pyridazinone ring as a core nucleus like sulmazole, levosimendan, amipizone, indolidan, imazodan, pimobendan, emorfazone, zardaverine, and milrinone …”