Comparison of azithromycin and clarithromycin in triple therapy regimens for the eradication of Helicobacter pylori

Sullivan, Brian; Coyle, Walter; Nemec, Richard; Dunteman, Thomas

doi:10.1111/j.1572-0241.2002.06036.x

Cited by 18 publications

(6 citation statements)

References 14 publications

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“…For this reason eradication rates obtained in the different studies varied widely (28-93%) [52;55-58]. A recent controlled trial did not confirm previous encouraging data and showed, for clarithromycin-based regimens, a higher eradication rate than azithromycin based ones [59]. action on the 50S bacterial ribosomal subunit, but clinical trials are needed to confirm these in vitro results [60][61].…”

Section: Macrolidesmentioning

confidence: 80%

Treatment of H. pylori Infection: A Review

Candelli

Nista²,

Carloni³

et al. 2005

CMC

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Helicobacter pylori infection has been indicated as the main pathogenic factor in the development of chronic gastritis, peptic ulcer disease, and gastric malignancies. Although the vast majority of infected subjects do not carry but a mild, asymptomatic gastritis, still there are some cases in which the eradication of the infection appears mandatory. This review addresses current anti-Helicobacter regimens and pharmacological resources, and highlights the pros and cons of each of them, according to the most recent and reliable clinical trials. Also, basic recommendations are given, regarding treatment choice in the event of the failure of a first or second line eradicating strategy, and about the implementation of standard regimens with newer antibacterial devices as probiotics.

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Section: Macrolidesmentioning

confidence: 80%

Treatment of H. pylori Infection: A Review

Candelli

Nista²,

Carloni³

et al. 2005

CMC

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“…The above mentioned characteristics make azithromycin an attractive choice to include in anti H. pylori regimens. So far multiple trials utilizing azithromycin based regimens with different methods, drug combinations, treatment durations, and with paradoxical results have been conducted (1,20,21,(30)(31)(32)(33)(34)(35)(36). Several studies obtained good efficacy in H. pylori eradication with short-term triple therapy using azithromycin, amoxicillin, and a proton pump inhibitor (33,37).…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori (H. pylori) is a ubiquitous human gastric infection, with different worldwide prevalence noted (1)(2)(3)(4)(5)(6), and it is a known cause of peptic ulcer disease (PUD) as well as gastric cancer (7)(8)(9). Eradication in patients with H. pylori related PUD leads to a significant decrease in ulcer recurrence (10,11).…”

Section: Introductionmentioning

confidence: 99%

Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial

Sarkeshikian¹,

Iranikhah²,

Ghadir³

2009

Turk J Gastroenterol

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clarithromycin, amoxicillin, and omeprazole and azithromycin, amoxicillin, and omeprazole, respectively, and completed the study course. Per protocol, eradication rate was 83% with clarithromycin, amoxicillin, and omeprazole and 75% with azithromycin, amoxicillin, and omeprazole (p =0.158). Eradication rate for a subgroup of patients with peptic ulcer disease in two groups were 83% and 74%, respectively (p=0.134

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“…We excluded 18 articles (10 non-clinical trials and eight unrelated articles) after examining the title and abstract, which left 39 potentially relevant articles for more detailed assessment. Of these potential eligible articles, 12 trials without a control group were excluded, and then we excluded another 17 articles, because of no combining with triple eradication regimens [7][8][9][10][11] , containing azithromycin in two regimens [12][13][14][15][16][17][18][19] , comparison of different treatment course of azithromycin [20,21] , no triple first-line therapy in control group [22] , and investigating relation between H pylori eradication and coronary heart disease [23] . Furthermore, we identified four additional articles from the Chinese Biomedical Database (1981 to May 2009).…”

Section: Description Of the Studiesmentioning

confidence: 99%

Azithromycin-containing versus standard triple therapy forHelicobacter pylori eradication: A meta-analysis

Dong

Yu²,

Zou³

2009

WJG

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AIM:To evaluate whether adding azithromycin to firstline Helicobacter pylori (H pylori ) eradication improved eradication and reduced side effects. METHODS:Eligible articles were identified by searches of electronic databases. We included all randomized trials that compared azithromycin-containing with standard triple-therapy regimens for first-line treatment of H pylori infection. Statistical analysis was performed with Review Manager 5.0.10. Sub-analyses were also performed. RESULTS:We identified 14 randomized trials (1431 patients). Pooled H pylori eradication rates were 72.01% (95% CI: 58.09%-85.93%) and 69.78% (95% CI: 66.47%-73.09%) for patients with or without azithromycin by intention-to-treat analysis, and the odds ratio (OR) was 1.17 (95% CI: 0.64-2.14). The occurrence of side effects differed significantly and was 15.81% (95% CI: 12.50%-19.12%) and 25.20% (95% CI: 21.44%-28.96%) for treatment with or without azithromycin, respectively, and the summary OR was 0.58 (95% CI: 0.41-0.82). Furthermore, the azithromycin-containing group had a lower occurrence of diarrhea, nausea and taste disturbance. CONCLUSION:Our review suggests that azithromycincontaining triple-therapy regimens could be equally effective in eradication of H pylori compared with standard first-line triple-therapy regimens.

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Comparison of azithromycin and clarithromycin in triple therapy regimens for the eradication of Helicobacter pylori

Abstract: The results of our study suggest that B-LAC is superior to B-LAA in the eradication of Helicobacter pylori. Our results also suggest that B-LAA is not a suitable regimen in the treatment of H. pylori because of its substandard eradication rate.

Cited by 18 publications

References 14 publications

Treatment of H. pylori Infection: A Review

Treatment of H. pylori Infection: A Review

Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial

Azithromycin-containing versus standard triple therapy forHelicobacter pylori eradication: A meta-analysis

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