Comparison of Azelastine versus Triamcinolone Nasal Spray in Allergic and Nonallergic Rhinitis

Kalpaklıoğlu, Ayşe Füsun; Kavut, Ayşe Baççıoğlu

doi:10.2500/ajra.2010.24.3423

Cited by 32 publications

(30 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Study characteristics are presented in Table IV. 50,55,[73][74][75][76] In summary, although study results are conflicting, there is evidence, however limited, that topical steroids improve specific measures of olfactory function, especially in patients with seasonal AR. …”

Section: Topical Steroidsmentioning

confidence: 94%

See 1 more Smart Citation

Olfaction in allergic rhinitis: A systematic review

Stuck

Hummel

2015

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Section: Topical Steroidsmentioning

confidence: 94%

“…The characteristics of these studies are presented in Table III. [70][71][72][73] In summary, there is very limited evidence that antihistamines improve olfactory function in the doses tested. Furthermore, in studies documenting an improvement in olfaction, the effects were relatively weak.…”

Section: Antihistaminesmentioning

confidence: 94%

Olfaction in allergic rhinitis: A systematic review

Stuck

Hummel

2015

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…Individuals with both nasal and ocular symptoms may benefit from INSs treatment. Indeed, recent clinical trial evidence in adults showed that INSs provided relief from the ocular symptoms of SAR/SAC [20,21,84,85,86,87]. However, few INSs have demonstrated this effect consistently in well-controlled clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

Lightman

Scadding²

2012

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Allergic rhinoconjunctivitis (ARC) presents as nasal symptoms, eye watering and additional signs of ocular allergy (e.g. itchy/burning eyes). Intranasal corticosteroids (INSs) are the most effective treatment for the nasal symptoms of seasonal allergic rhinitis (SAR; based on 4 meta-analyses) and are considered first-line therapy when nasal congestion forms a substantial component of the patient’s rhinitis symptoms. Clinical trial evidence shows that INSs also provide some relief from ocular symptoms of SAR and seasonal ARC in adults. INSs probably alleviate eye watering, the main ocular symptom of SAR, by relieving nasal congestion. Other ocular symptoms also improve with INSs. The mechanism for this effect is unknown, but might relate to naso-ocular reflex reduction. There are limited data on ocular safety with INSs. However, the literature supports the use of INSs over several months as there appears to be no considerable increase in the risk of ocular hypertension or glaucoma.

show abstract

“…[11] In a study done comparing nasal H1-antihistamine and nasal glucocorticoid in patients with allergic and nonallergic rhinitis, azelastine was as effective as triamcinolone in improving nasal symptoms; sleep symptoms and quality of life. [12] H1-antihistamines are not medications of choice in asthmatic patients. However, comorbidity of asthma and allergic rhinitis is very high (80%) and they have clinically relevant antiasthmatic properties by controlling rhinitis.…”

Section: Antihistaminesmentioning

confidence: 99%

Role of leukotriene antagonists and antihistamines in treatment of allergic rhinitis and asthma comorbidity

Baççıoğlu¹

2013

J Med Updates

View full text Add to dashboard Cite

Allergy is a reaction with inflammatory cell infiltration in the target organ which allergen has been found to cause the pathology. [1,2] Allergens cause an immunoglobulin (Ig) E dependent reaction characterized by an early and late phase reaction. Histamine is released after 15 min of exposure to allergen, whereas leukotriene is increased in the AbstractLeukotriene receptor antagonists and antihistamines are efficient in reducing symptoms of allergic rhinitis and asthma when used alone or in combination. In patients with allergic rhinitis, H1-antihistamines prevent and relieve the sneezing, itching, rhinorrhea, and nasal congestion that characterize the early and the late response to allergen. H1-antihistamines are not medications of choice in asthmatic patients, but controlling rhinitis will improve asthma concomitantly. Leukotriene antagonist such as montelukast may be an alternative treatment for mild persistent asthma as monotherapy where inhaled corticosteroid cannot be administered or alternative to long-acting beta agonist as an add-on therapy to ICS for moderate to severe persistent asthma. Although montelukast is an effective drug in allergic rhinitis indicated as monotherapy, but widely recommended as adjunct to antihistamine or intranasal corticosteroid. Antileukotriene agents are also widely used in the treatment of pediatric asthma. In children, maintenance treatment with inhaled corticosteroids in pure episodic (viral) wheeze was ineffective, but maintenance as well as intermittent montelukast was shown to have an efficient role in both episodic and multi trigger wheeze. Furthermore, their advantage to inhaled corticosteroids is that leukotriene receptor antagonists do not affect short-term lower leg growth rate in prepubertal children.Key words: Leukotriene antagonist; antihistamines; allergic rhinitis; asthma. ÖzetYaln›z bafllar›na veya kombinasyon fleklinde kullan›ld›klar›nda lökotri-yen reseptörleri ve antistaminikler alerjik rinit semptomlar›n› azaltmada etkilidir. Alerjik rinit hastalar›nda H1 antistaminikleri alerjene yan›-t›n erken ve geç dönem yan›tlar› olan aks›rma, kafl›nma, burun akmas› ve nazal konjestiyonu önlemekte ve geçirmektedir. Ast›m hastalar›nda H1-antistaminikleri seçilecek ilaçlar olmamalar›na ra¤men rinitin kontrol alt›na al›nmas› ayn› zamanda ast›m› da iyilefltirecektir. Orta-a¤›r derecede fliddetli inatç› ast›mda inhale kortikosteroidin ek tedavi olarak verilemedi¤i veya uzun etkili beta agonistin alternatif olmad›¤› durumlarda hafif derecede ve inatç› ast›m›n alternatif tedavisi olarak montelukast gibi bir lökotriyen antagonistiyle monoterapi uygulanabilir. Alerjik rinitte monoterapi olarak montelukast etkili bir ilaç olmas›na ra¤men yayg›n olarak antistamin veya intranazal kortikosteroide ek olarak öne-rilmektedir. Antilökotriyen ilaçlar yine pediyatrik ast›m›n tedavisinde yayg›n biçimde kullan›lmaktad›r. Çocuklarda kortikosteroitler inhalasyonlar›yla idame tedavisi olarak saf epizodik (viral) h›fl›lt›l› solunum (wheezing) tedavisinde etkisiz olmalar›na ra¤men hem deva...

show abstract

Comparison of Azelastine versus Triamcinolone Nasal Spray in Allergic and Nonallergic Rhinitis

Abstract: In this first comparative demonstration, AZENS appears to be as effective as triamcinolone in symptom scores, nPIFR, ESS, and HRQoL, equally in AR and NAR.

Cited by 32 publications

References 30 publications

Olfaction in allergic rhinitis: A systematic review

Olfaction in allergic rhinitis: A systematic review

Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

Role of leukotriene antagonists and antihistamines in treatment of allergic rhinitis and asthma comorbidity

Contact Info

Product

Resources

About