Comparison of Autologous Serum Versus Preservative Free Artificial Tear in Patients with Dry Eyes Due to Systemic Isotretinoin Therapy

Yılmaz, Uğur; Küçük, Erkut; Koç, Çağdaş; Gökler, Mehmet Enes

doi:10.1080/02713683.2016.1255758

Cited by 15 publications

(29 citation statements)

References 33 publications

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“…Four [24][25][26][27] of the seven studies reported Schirmer I test and all of them showed an increase in tear secretion. Nevertheless, the combined results revealed no significant difference.…”

Section: Discussionmentioning

confidence: 99%

“…Secondly, the severity of DED in the patients included in the seven studies was inconsistent. Three [26,29,32] of the studies included 52 subjects with severe DED, one study [27] included 96 subjects with moderate to severe DED, and the others did not identify the severity of DED [24,25,33]. Thirdly, there were differences in the dosage, frequency, and treatment course in the seven studies, which potentially affected prognosis to some extent.…”

Section: Discussionmentioning

confidence: 99%

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Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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Objective: To compare the efficacy of autologous serum (AS) eye drops and artificial tears (AT) in dry eye disease (DED). Methods: Five databases (PubMed, Science Direct, the Cochrane Library, the Chinese National Knowledge Infrastructure, and the Wanfang Database) were searched for randomized controlled trials (RCTs). Efficacy was evaluated in terms of the Ocular Surface Disease Index (OSDI), Schirmer I test, tear break-up time (TBUT), and fluorescein and rose bengal staining of ocular surface. The estimated effects of AS or AT were expressed as a proportion with the 95% confidence interval and plotted on a forest plot. Results: Seven RCTs with 267 subjects were included in the meta-analysis. For most of the studies, subjects' age was around 50 years old, and the mostly treatment duration was within 8 weeks. The followup results showed that the OSDI after AS treatment was lower than that after the AT treatment: the mean difference (MD) was-10.75 (95% CI,-18.12;-3.39) points. There was no difference on the Schirmer I test after treatment between the two groups: the MD was 1.68 (95% CI,-0.65; 4.00) mm. The TBUT of the AS group was longer than that of the AT group, with an MD of 4.53 (95% CI, 2.02; 7.05) s. There was no statistically significant difference on fluorescein staining score of the ocular surface between the AS group and the AT group, the MD was-2.53 (95% CI,-6.08; 1.03) points. The rose bengal staining score of the AS group was slightly lower than that of the AT group after treatment: the MD was-0.78 (95% CI,-1.34;-0.22) points. Conclusion: AS could be an effective treatment for DED, improving OSDI, TBUT, and rose bengal staining score. Further RCTs with large samples and longterm follow-up are still needed to determine the exact role of AS in the management of DED.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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“…Six RCTs investigated the efficacy of auto-SED for the treatment of severe DED (Table 1) [49,50,51,52,53,54]. Improvement of symptoms and signs (tear breakup time (TBUT), corneal staining, and conjunctival impression cytology) was reported in severe DED patients after therapy with auto-SED and tear substitutes with [50,51] or without [49] significant differences between the groups.…”

Section: Autologous Serum Eye Dropsmentioning

confidence: 99%

“…Two recent cross-over trials on severe DED reported a higher decrease of symptoms score in the auto-SED group compared to the control group treated with tear substitutes [52,53]; nevertheless, a significant improvement of TBUT was also reported in the auto-SED group only in the study from Celebi [53]. Yilmaz et al reported a significant magnitude of the mean improvement of symptoms and TBUT in patients with DED due to systemic isotretinoin after auto-SED therapy compared to those treated with tear substitutes [54].…”

Section: Autologous Serum Eye Dropsmentioning

confidence: 99%

Blood-Based Treatments for Severe Dry Eye Disease: The Need of a Consensus

Bernabei

Roda

Buzzi

et al. 2019

JCM

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The use of blood-based eye drops as therapy for various diseases of the ocular surface has become increasingly popular in ophthalmic practice during recent years. The rationale for their use is based on the promotion of cellular proliferation and migration thanks to the supply of metabolically active substances, in particular growth factors. Blood-derived eye drops have been used for the treatment of several ocular surface disorders, such as dry eye disease, corneal ulcer, persistent epithelial defect, neurotrophic keratitis, ocular surface burn, recurrent corneal erosion, and limbal stem-cell deficiency. Both autologous (from patients themselves) and heterologous (from adult donors or from cord blood sampled at birth)-derived products exist, and each source has specific pros and cons. Despite an extensive literature, several issues are still under debate and the aim of this manuscript is to review the indications, preparation methods and storage, characterization of content, rationale for clinical outcomes, patient stratification, length of treatment, and rationale for repeated treatments at disease relapse. A rationale based on a “5 Ws and 2 Hs” protocol is proposed as a way of thinking, with the attempt to clarify Who, Why, When, Where, What, and How to use these treatment options.

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“…Algunos estudios, 56,94,[139][140][141][142][143][144][145][146][147][148][150][151][152][153] han encontrado mejores resultados con la utilización del colirio de SA en patologías como queratitis sicca, defectos epiteliales persistentes o úlceras corneales, ya que en estos casos, existe una ausencia de factores epiteliotróficos y la utilización del colirio de SA presenta clara mejoría. Tananuvat et al 139 compararon el uso del colirio de SA frente al uso de lágrimas artificiales en la DED, y aun sin encontrar diferencias estadísticamente significativas, afirmaron que el grupo tratado con SA presentó una clara tendencia a la mejoría de la sintomatología, incluyendo cambios en la CIC.…”

Section: Saunclassified

Empleo del colirio de suero autólogo en el tratamiento de la enfermedad del ojo seco

Valencia¹,

Liliana²

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Comparison of Autologous Serum Versus Preservative Free Artificial Tear in Patients with Dry Eyes Due to Systemic Isotretinoin Therapy

Abstract: AS may be an effective alternative to PFAT in the treatment of dry eye developed during isotretinoin use.

Cited by 15 publications

References 33 publications

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Blood-Based Treatments for Severe Dry Eye Disease: The Need of a Consensus

Empleo del colirio de suero autólogo en el tratamiento de la enfermedad del ojo seco

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