Comparison of Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium by simultaneous determination of multi‐components with single reference standard method and chemometric analysis

Guo, Long; Zhang, Dan; Xue, Zhang; Jiao, Qian; Aipeng, Liu; Zheng, Yuguang; Liu, E‐Hu; Duan, Li

doi:10.1002/pca.2786

Cited by 18 publications

(13 citation statements)

References 25 publications

(58 reference statements)

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“…In order to comprehensively compare the extraction efficiency of DESs and conventional solvents for extraction of phenolic acids from AL, different ratios of methanol (25% MeOH, 50% MeOH, 75% MeOH, and 100% MeOH), efficient solvents commonly used in the extraction of bioactive compounds from natural products, were selected as reference solvents [7]. As shown in Figure 2, among the different ratios of MeOH, 75% MeOH displayed the highest extraction efficiency for the four phenolic acids.…”

Section: Resultsmentioning

confidence: 99%

“…Although the AL has been used as an herbal medicine and food ingredient for a long time, studies on its bioactive compositions are still limited. Phytochemical studies disclosed that AL contains various bioactive constituents, mainly including volatile oils, phenolic acids, flavonoids, and terpenoids [6,7]. Among bioactive constituents, phenolic acids have been recognized as the main active compounds in AL [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…To date, several bioactive phenolic acids, such as 3-caffeoylquinic acid, 3,4-di- O -caffeoylquinic acid, 3,5-di- O -caffeoylquinic acid, and 4,5-di- O -caffeoylquinic acid, have been isolated from AL. A number of analytical methods, including high-performance liquid chromatography (HPLC) and high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS), have been used for qualitative and quantitative analysis of the main phenolic acids in AL [5,7]. However, the research focused on extraction methods for bioactive phenolic acids from AL is still limited.…”

Section: Introductionmentioning

confidence: 99%

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Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

Duan

Zhang

et al. 2019

Molecules

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The Artemisia argyi leaf (AL) has been used as a traditional medicine and food supplement in China and other Asian countries for hundreds of years. Phytochemical studies disclosed that AL contains various bioactive constituents. Among bioactive constituents, phenolic acids have been recognized as the main active compounds in AL. To the best of our knowledge, no research has been focused on extraction method for the bioactive phenolic acids from AL. Nowadays, deep eutectic solvents (DESs) are emerging as a new type of green and sustainable solvent for efficient extraction of bioactive compounds from natural products. In the present study, an environmentally friendly extraction method based on DESs was established to extract bioactive phenolic acids from ALs. Diverse tailor-made solvents, including binary and ternary DESs, were explored for simultaneous extraction of four phenolic acids (3-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, and 4,5-di-O-caffeoylquinic acid) from AL. The results indicated that the ternary DES composed of a 2:1:2 molar ratio of choline chloride, malic acid, and urea showed enhanced extraction yields for phenolic acids compared with conventional organic solvents and other DESs. Subsequently, the extraction parameters for the four phenolic acids by selected tailor-made DESs, including liquid–solid ratios, water content (%) in the DESs, and extraction time, were optimized using response surface methodology and the optimal extraction conditions were: extraction time, 23.5 min; liquid–solid ratio, 57.5 mL/g (mL of DES/g dry weight of plant material); water content, 54%. The research indicated that DESs were efficient and sustainable green extraction solvents for extraction of bioactive phenolic acids from natural products. Compared to the conventional organic solvents, the DESs have a great potential as possible alternatives to those organic solvents in health-related areas such as food and pharmaceuticals.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

Duan

Zhang

et al. 2019

Molecules

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“…As an edible herbal medicine, AL has been widely used in clinic in China and other Asia countries. Our previous studies have shown that polyphenols, including caffeoylquinic acids and flavonoids, are main bioactive constituents in AL, which has been reported to display hypoglycemic and hypolipidemic properties (Guo et al, 2019). However, there is no information about the potential anti-lipase of AL.…”

Section: Discussionmentioning

confidence: 99%

“…The leaves of Artemisia argyi H.Lév. and Vaniot (AL), a common herbal medicine for treatment of hemorrhage, dysmenorrhea, abdominal pain eczema and skinitch (Guo et al, 2019), which is mainly distributed in China, Korea, Mongolia, and Japan (Abad et al, 2012). AL is also used as a food ingredient due to its delicious flavor and characteristic smell (Xiao et al, 2019)., AL is consumed as a condiment and colorant for the traditional food "Qingtuan" in China, and AL is also used as an additive in dietary food to enhance the flavor and nutrition in Japan (Abad et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Screening of Anti-Lipase Components of Artemisia argyi Leaves Based on Spectrum-Effect Relationships and HPLC-MS/MS

et al. 2021

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Pancreatic lipase is a key lipase for triacylglyceride digestion and absorption, which is recognized as a promising target for treatment of metabolic disorders. Natural phytochemicals are hopeful sources for pancreatic lipase inhibitors. The leaves of Artemisia argyi H.Lév. and Vaniot (AL) is commonly used as herbal medicine or food supplement in China and other Asian countries for hundreds of years. AL mainly contains essential oils, phenolic acids, flavonoids and terpenoids, which exhibit many pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, analgetic, anti-cancer, anti-diabetes and immunomodulatory effects. However, the anti-lipase activity of AL was lack of study and the investigation of anti-lipase ingredients from AL was also insufficient. In the present study, the anti-lipase activity of AL was evaluated in vitro and the potentially pancreatic lipase inhibitors of AL were investigated. High performance liquid chromatography was used to establish fingerprints of AL samples, and fifteen peaks were selected. The anti-lipase activities of AL samples were evaluated by a pancreatic lipase inhibition assay. Then, the spectrum-effect relationships between fingerprints and pancreatic lipase inhibitory activities were investigated to identify the anti-lipase constitutes in AL. As the results, four caffeoylquinic acids, which were identified as neochlorogenic acid, chlorogenic acid, isochlorogenic acid B, and isochlorogenic acid A by high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, were selected as potential pancreatic lipase inhibitors in AL. Moreover, anti-lipase activity assessment and molecular docking study of the four compounds were performed to validate the potential lipase inhibitors in AL. The results revealed that the four caffeoylquinic acids in AL as bioactive compounds displayed with anti-lipase activity. The present research provided evidences for the anti-lipase activity of AL, and suggested that some bioactive compounds in AL could be used as lead compounds for discovering of new pancreatic lipase inhibitors.

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Rapid screening and evaluation of natural antioxidants from leaf, stem, and root of Artemisia argyi by online liquid microextraction combined with HPLC‐based antioxidant assay system coupled with calibration quantitative analysis

Yang,

Huang,

et al. 2023

J of Separation Science

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To reveal the utilization value of leaf, stem, and root of Artemisia argyi, a rapid online liquid microextraction combined with a high‐performance liquid chromatography coupled with 2,2‐nitrogen‐di (3‐ethyl‐benzothiazole‐6‐sulfonic acid) diammonium salt antioxidant assay system was established for analysis of antioxidants in the leaf, stem, and root of A. argyi, and a calibration quantitative method of antioxidant activity with equivalent chlorogenic acid was proposed. Thirty‐three positive peaks were identified; among them, 12 compounds were found that possess good antioxidant activity including eleven organic acids (components 2–4, 8, 11–14, 17, 19, and 21) and one flavonoids (component 22). The proposed calibration quantitative method avoided the influence of content of compound and compared the extent of radical scavenging capacity of five antioxidant compounds, which were ranked as follow: 3,5‐dicaffeoylquinic acid > 3,4‐dicaffeoylquinic acid ≈ 4,5‐dicaffeoylquinic acid > 1,4‐dicaffeoylquinic acid > chlorogenic acid. In conclusion, this study provided composition and biological potential for the future development of the leaf, stem, and root of A. argyi. It is believed that the online liquid microextraction combined with high‐performance liquid chromatography based antioxidant assay system can be widely used for the rapid screening of natural antioxidant components in the different parts of natural products.

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Comparison of Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium by simultaneous determination of multi‐components with single reference standard method and chemometric analysis

Abstract: The single reference standard for simultaneous determination of the multi-components method coupled with chemometrics analysis could be a well-acceptable strategy to compare and evaluate the quality of Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium.

Cited by 18 publications

References 25 publications

Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

Screening of Anti-Lipase Components of Artemisia argyi Leaves Based on Spectrum-Effect Relationships and HPLC-MS/MS

Rapid screening and evaluation of natural antioxidants from leaf, stem, and root of Artemisia argyi by online liquid microextraction combined with HPLC‐based antioxidant assay system coupled with calibration quantitative analysis

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