Comparison of Arginine Vasopressin, Terlipressin, or Epinephrine to Correct Hypotension in a Model of Anaphylactic Shock in Anesthetized Brown Norway Rats

Dewachter, Pascale; Jouan–Hureaux, Valérie; Lartaud, Isabelle; Bello, Gaëlle; Talancé, Nicole de; Longrois, Dan; Mertès, Paul-Michel

doi:10.1097/00000542-200604000-00018

Cited by 37 publications

(26 citation statements)

References 29 publications

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“…This result is consistent with the experimental and clinical fact that the p-AVP concentration decreases in anaphylactic or septic shock with vasodilatory hypotension and acute respiratory distress (13,14).…”

Section: Comparison Of P-avp Levels Among Control Animals Sensitizedsupporting

confidence: 91%

Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotriene Receptor Antagonist

Takeda

Takeda²,

Egami³

et al. 2012

Otology &Amp; Neurotology

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Section: Comparison Of P-avp Levels Among Control Animals Sensitizedsupporting

confidence: 91%

Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotriene Receptor Antagonist

Takeda

Takeda²,

Egami³

et al. 2012

Otology &Amp; Neurotology

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“…87 Studies in animals have demonstrated potential benefit with the use of phenylephrine, norepinephrine, vasopressin and methylene blue in animal models of anaphylactic shock. [88][89][90] There are multiple case reports describing the use of vasopressin, norepinephrine and methylene blue in patients with anaphylaxis refractory to epinephrine. [91][92][93][94][95][96][97][98][99][100][101] Consensus guidelines recommend the use of an epinephrine infusion if a vasopressor infusion is required for patients with anaphylactic shock.…”

mentioning

confidence: 99%

Vasopressor and Inotrope Use in Canadian Emergency Departments: Evidence Based Consensus Guidelines

Djogovic

MacDonald

Wensel

et al. 2015

CJEM

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“…It has direct cerebral vasodilating effects and therefore would produce arterial hypotension and cerebral vasodilation without a significant decrease in CO (12) in the absence of any inflammatory component. This model has been characterized previously by our group (10,13,14).…”

Section: Discussionmentioning

confidence: 99%

Anaphylactic Shock Decreases Cerebral Blood Flow More Than What Would Be Expected From Severe Arterial Hypotension

Davidson¹,

Zheng²,

Tajima³

et al. 2012

Shock

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The effects of acute reduction in arterial blood pressure in severe anaphylactic shock (AS) on cerebral blood flow are of paramount importance to be investigated. We studied cerebral circulation and oxygenation in a model of severe AS and compared it with a pharmacologically induced arterial hypotension of similar magnitude. Anaphylactic shock was induced by 1 mg intravenous ovalbumin (OVA) in sensitized rats. Rats were randomized to three groups: (i) no resuscitation (OVA; n = 10) (ii) intravenous volume expansion (10 mL in 10 min after OVA injection) (OVA + VE; n = 10); (iii) control hypotension (100 μg of nicardipine followed by continuous infusion of 1 mg · 100 g · h intravenously; NICAR; n = 10). Mean arterial pressure (MAP), carotid blood flow (CBF), cardiac output, cerebral cortical blood flow (CCBF; estimated by laser Doppler technique), and cerebral tissue oxygen pressure (PtiO2) were recorded over the 15 min following AS induction in all three groups. Results are expressed as mean (SD). One minute after OVA or nicardipine injection, there was a rapid and significant 50% decrease in MAP from basal values. In the OVA group, AS severely altered systemic and cerebral hemodynamics in 5 min: 93% (SD, 4%) decrease in CBF, 66% (SD, 8%) in CCBF, and 44% (SD, 8%) in PtiO2; the decrease in CBF was significantly (P< 0.05) attenuated in the OVA + VE group; however, CCBF and PtiO2 were not statistically different in the OVA versus OVA + VE groups. On the contrary, nicardipine-induced hypotension had only a limited impact on CBF, cardiac output, CCBF, and PtiO2 for a similar MAP decrease. There was a linear relation between CCBF and blood pressure in the OVA (regression slope: 0.87 [SD, 0.06]; median r = 0.81) but not in the NICAR group (regression slope: 0.23 [SD, 0.32]; median r = 0.33). Anaphylactic shock resulted in severe impairment of cerebral blood flow and oxygenation, beyond what could be expected from the level of arterial hypotension.

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Comparison of Arginine Vasopressin, Terlipressin, or Epinephrine to Correct Hypotension in a Model of Anaphylactic Shock in Anesthetized Brown Norway Rats

Cited by 37 publications

References 29 publications

Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotriene Receptor Antagonist

Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotriene Receptor Antagonist

Vasopressor and Inotrope Use in Canadian Emergency Departments: Evidence Based Consensus Guidelines

Anaphylactic Shock Decreases Cerebral Blood Flow More Than What Would Be Expected From Severe Arterial Hypotension

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