Comparison of Antioxidative Properties of Carbazole Alkaloids from Murraya koenigii Leaves

Abstract

A new dimeric carbazole alkaloid, 8,10'-[3,3',11,11'-tetrahydro-9,9'-dihydroxy-3,3',5,8'-tetramethyl-3,3'-bis(4-methyl-3-pentenyl)]bipyrano[3,2-a]carbazole (12), was isolated from the CH(2)Cl(2) extract of Murraya koenigii together with six known carbazole alkaloids, koenimbine (6), O-methylmurrayamine A (7), O-methylmahanine (8), isomahanine (9), bismahanine (10), and bispyrayafoline (11). Their structures were determined on the basis of (1)H and (13)C NMR spectroscopic and mass spectrometric (MS) data. The antioxidative properties of 12 carbazole alkaloids isolated from leaves of M. koenigii were evaluated on the basis of the oil stability index together with their radical scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. On the basis of the lag time to reach a steady state, the 12 carbazoles were classified into three groups. It is suggested that an aryl hydroxyl substituent on the carbazole rings plays a role in stabilizing the thermal oxidation and rate of reaction against DPPH radical.

Effects of temperature and solvent on antioxidant properties of curry leaf (Murraya koenigii L.)

“…It is suggested that an aryl hydroxyl substituent on the carbazole ring plays a role in stabilizing the thermal oxidation and rate of reaction against DPPH radical (Tachibana et al 2003). …”

Determination of Pesticide Residues in curry leaf in local markets of Hyderabad, India

“…Chevalier (1996) also reported that curry leaf has medicinal value as traditionally used in Eastern Asia. Interest in greater use of curry leaf has been stimulated since its high antioxidant potency was reported and this antioxidant activity is attributed due to maha nimbine, murrayanol and mahanine from M. koenigii (Tachibana et al, 2003;Ningappa et al,2008). Chowdhury et al (2001) reported that these alkaloids have antimicrobial activity against gram positive and negative bacteria, and fungi.…”

Hydroalcoholic and Alkaloidal Extracts of Murraya koenigii(L.) Spreng Augments Glucose Uptake Potential against Insulin Resistance Condition in L6 Myotubes and Inhibits Adipogenesis in 3T3L1 Adipocytes

“…5 The aerial part of MK has been prescribed for diabetes in Ayurveda systems of medicine. 6 The crude leaf extract of MK was reported for its antioxidant, 7 anti -bacterial, 8 anti -inflammatory, 9 and topo-isomerases inhibition. 10 While studies have revealed the anti -diabetic property of MK 11,12,13 inconsistent results on the effect of MK extracts have also been reported.…”