Comparison of Antiobesity Effects of Adipose-Derived Stromal/Stem Cells from Different Sources in a Natural Aging Model

Zhu, Yu; Wang, Tao; He, Shuangli; Pu, Shiming; Zhao, Hongxia; Zhou, Zuping; Wu, Qiong

doi:10.2147/dmso.s334044

Cited by 1 publication

(2 citation statements)

References 28 publications

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“…Our previous study showed that transplantation of young mouse ASCs (Y-ASCs) reduced body weight and abdominal adipose tissue in aged mice [ 31 ]. However, the effects of ASC transplantation from old donors (O-ASCs) are yet to be defined.…”

Section: Resultsmentioning

confidence: 99%

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Anti-aging mechanism of different age donor-matched adipose-derived stem cells

Wang

Zhu

et al. 2023

Stem Cell Res Ther

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Background Adipose-derived stem cells (ASCs) have anti-aging and anti-obesity effects in aged animals, but the underlying molecular mechanism remains unknown. Methods In the present study, we evaluated the in vivo transplantation effects of different age donor-matched ASCs on natural aging and leptin knockout mice (ob−/ob− mice). The multi-omics expression profiles of young and aged mouse donor-derived ASCs were also analyzed. Results The results revealed that ASCs from young donors induced weight and abdominal fat loss for older recipients but not for young or ob−/ob−mice. The young and aged mouse donor ASCs displayed significant phenotypic differences, contributing to the distinguished weight loss and anti-aging effects in aged mice. Conclusions Our data suggest an underlying molecular mechanism by which young-donor ASCs reduce immune cells and inflammation in aged mice via secreted immune factors. These findings point to a general anti-aging mechanism of stem cells, which may provide new insights into age-related disturbances of stem cell plasticity in healthy aging and age-related diseases.

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Section: Resultsmentioning

confidence: 99%

“…In light of our recently labeled ASCs for tracing, only a handful of cells survived after seven days of transplantation [ 31 ]. Therefore, the effects of cell transplantation are mainly caused by secreted proteins or small molecules induced by stem cells, consistent with other reports [ 4 , 17 , 18 ].…”

Section: Resultsmentioning

confidence: 99%