Comparison of antimuscarinic drugs to beta adrenergic agonists in overactive bladder: A literary review

Abstract

Background: The purpose of this study was to carry an extended literature review to compare antimuscarnics with beta adrenergic agonists (mirabegron) in treatment of overactive bladder. Materials and methods: A literature review was carried out, using key words in different databases including MEDLINE, PUBMED, and EMBASE. All relevant published articles during last 5 years with full texts available were included in this review for critical analysis and evaluation. In total, there were 20 studies including 7 systemic reviews, 6 retrospective cohort, 3 prospective cohort, 2 randomized controlled trials, and 2 cross sectional studies. Results: After critical evaluation the results were considered under parameters of efficacy, adverse effects, adherence and persistence, tolerability, cost-effectiveness. In 9 studies efficacy was evaluated, 5 studies dealt with adverse effects, same number evaluated adherence and persistence. Cost effectiveness was compared in 3 and same number of studies also compared tolerability. Conclusions: To conclude, we found mirabegron is as efficacious as any other antimuscarnics, has better tolerability (including elderly), has better adverse effect profile, is cost effective, has better persistence and adherence rates at 12 months.

Effectiveness of Antimuscarinics and Beta-3 Adrenoceptor in Adult Female with Overactive Bladder

“…Wani et al (15) revealed that nine research examined the efficacy of these two classes of drugs in their meta-analysis. According to the findings of all the trials, mirabegron is just as effective as any other anticholinergic.…”

“…Wani et al (15) indicated that five studies analyzed the negative effects of both treatments in their metaanalysis and found that mirabegron has less side effects than antimuscarinics.…”