Comparison of antimelanoma effects of 4-S-cysteaminylphenol and its homologues

Melanogenesis and Melanoma

“…As melanogenesis is a potential cytotoxic hazard to pigmentgenerating cells and is generally over-expressed in malignant melanoma, it is reasonable to suppose a priori that the pathway might be profitably used as a targeting strategy for the elimination of malignant melanocytes (6). There are several possibilities, some of which have received attention in the past (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). In general, there are two approaches which are referred to as 'Achilles heel' and 'Trojan horse'.…”

Sulfonic Acid Functionalized Nano‐γ‐Al2O3: A New, Efficient, and Reusable Catalyst for Synthesis of 3‐Substituted‐2H‐1,4‐Benzothiazines

“…They have received considerable attention in the field of pharmaceutical industry owing to their broad range of biological activities such as antifungal [1, 2], immunostimulating [3], antirheumatic [4], antiallergic [5], and antitumor activities [6]. 1,4-Benzothiazines are also active on the cardiovascular system, and the vasorelaxant, antiarrhythmic, and antihypertensive effects have been reported [7–11].…”

Effects of long-term oral administration of polymeric microcapsules containing tyrosinase on maintaining decreased systemic tyrosine levels in rats

“…Other antitumor agents specific for malignant melanoma has been studied by many research groups. Inoue et al24 showed that 4‐S‐Cysteaminylphenol (4‐S‐CAP) is one of the most promising antimelanoma agents. Tyrosinase converts 4‐S‐CAP into a toxic metabolite with melanocytotoxicity and thus inhibits the growth of B16 melanoma.…”