Comparison of antibody responses after vaccination with two inactivated rabies vaccines

Minke, J.M.; Bouvet, J.; Cliquet, Florence; Wasniewski, Marine; Guiot, Anne-Laure; Lemaître, L.; Cariou, C.; Cozette, V.; Vergne, Laurence; Guigal, Pierre-Michel

doi:10.1016/j.vetmic.2008.06.024

Cited by 57 publications

(55 citation statements)

References 12 publications

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“…and s.c. vaccination. Both application routes elicit VNA titers higher than 0.5 IU/ml within 7 days, peaking around day 14 after immunization, similar to results after application of inactivated rabies vaccines (70). Booster s.c. or i.m.…”

Section: Discussionsupporting

confidence: 73%

A New Rabies Vaccine Based on a Recombinant Orf Virus (Parapoxvirus) Expressing the Rabies Virus Glycoprotein

Amann

Rohde

Wulle

et al. 2013

J Virol

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The present study describes the generation of a new Orf virus (ORFV) recombinant, D1701-V-RabG, expressing the rabies virus (RABV) glycoprotein that is correctly presented on the surface of infected cells without the need of replication or production of infectious recombinant virus. One single immunization with recombinant ORFV can stimulate high RABV-specific virus-neutralizing antibody (VNA) titers in mice, cats, and dogs, representing all nonpermissive hosts for the ORFV vector. The protective immune response against severe lethal challenge infection was analyzed in detail in mice using different dosages, numbers, and routes for immunization with the ORFV recombinant. Long-term levels of VNA could be elicited that remained greater than 0.5 IU per ml serum, indicative for the protective status. Single applications of higher doses (10 7 PFU) can be sufficient to confer complete protection against intracranial (i.c.) challenge, whereas booster immunization was needed for protection by the application of lower dosages. Anamnestic immune responses were achieved by each of the seven tested routes of inoculation, including oral application. Finally, in vivo antibody-mediated depletion of CD4-positive and/or CD8-posititve T cell subpopulations during immunization and/or challenge infection attested the importance of CD4 T cells for the induction of protective immunity by D1701-V-RabG. This report demonstrates another example of the potential of the ORFV vector and also indicates the capability of the new recombinant for vaccination of animals.

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Section: Discussionsupporting

confidence: 73%

A New Rabies Vaccine Based on a Recombinant Orf Virus (Parapoxvirus) Expressing the Rabies Virus Glycoprotein

Amann

Rohde

Wulle

et al. 2013

J Virol

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“…A previous study also demonstrated that the VNA titer dropped to º0.5 IU/ml in À50z of dogs vaccinated within 120 days after a single vaccination (11). In the current study, however, the VNA levels in dogs that had received a single vaccination were higher 13 months after a single vaccination than that within 12 months of vaccination (Figs.…”

Section: Discussioncontrasting

confidence: 57%

Relationship between Virus-Neutralizing Antibody Levels and the Number of Rabies Vaccinations: a Prospective Study of Dogs in Japan

et al. 2013

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SUMMARY:A mass rabies vaccination of dogs has been conducted annually in Japan over the last 60 years. To assess both current levels of rabies virus-neutralizing antibody (VNA) in dogs and the rationale for current vaccination procedures, we used a rapid fluorescent focus inhibition test to determine VNA levels in 756 dogs that had visited animal hospitals in Japan. We found that 51.1z of the dogs that had received 1 rabies vaccination had protective VNA levels (AE0.5 IU/ml) with a geometric mean of 0.61 IU/ml. In contrast, 97.8z of the dogs that had been vaccinated at least twice had protective VNA levels with a geometric mean of 7.86 IU/ml. Furthermore, 97.9-100z of the dogs vaccinated at least twice retained protective VNA levels into the second year after the last vaccination. Although VNA levels in the dogs vaccinated at least twice tended to decline 2 years after the last vaccination, 78.9z retained protective VNA levels. Thus, the current rabies vaccination schedule provides adequate protection, but the registration system and vaccination schedule needs to be improved to ensure that increased numbers of dogs are vaccinated against rabies.

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“…Similar observations of peak antibody titre during 3-6 weeks post vaccination and waning of antibody titre were made earlier (Aubert, 1992;Oliveira et al, 2000;Manickam et al, 2008;Minke et al, 2009). Although reduction in the antibody response on the day 90 was expected, it's reduction below 0.5 IU in case of 3 animals was unexpected.…”

Section: Resultssupporting

confidence: 82%

Sero monitoring of anti rabies vaccinal antibodies to pep in animals by RFFIT - a case study in Karnataka

KM¹,

Isloor²,

C³

et al. 2016

JEBAS

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KEYWORDS RabiesPost exposure prophylaxis Neutralizing antibodies Animals RFFIT ABSTRACTA dog suspected to be affected with rabies attacked 31 animals in Kesarahatti village of Gangavathi taluk, Koppal District in Karnataka on 14 th June 2015. Of these, 26 animals (14 cattle, 5 buffaloes and 7 dogs) were given the first aid followed by post exposure anti rabies vaccine at 1 (15 th June 2015), 3, 7, 14 and 28 days interval whereas the remaining 5 animals (2 cattle and 3 buffaloes) reportedly died of suspected (based on clinical manifestation) rabies after 8 days of dog bite episode. These 5 animals were not provided first aid and post exposure prophylactic (PEP) vaccination as their exposure to the rabid dog bite went unnoticed. Further, the serum samples could be collected from only 21 out of 26 vaccinated animals on 28 th and 90 th day post vaccination. These serum samples were tested by Rapid Fluorescent Focus Inhibition Test (RFFIT) and the titre of neutralizing antibodies ranged from 1-8 IU/ml from the serum collected on 28 th day post vaccination indicating protection in all the vaccinated animals. But the titre ranged from 0.5-4 IU/ml in 18 animals and less than 0.5 IU/ml in three animals (2 cows and a dog) on 90 th day post vaccination. The protective level of neutralizing antibody titre on day 28 post vaccination and non-development of disease suggests that the PEP vaccination could be effective in livestock avoiding euthanasia and culling of animals.

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Comparison of antibody responses after vaccination with two inactivated rabies vaccines

Cited by 57 publications

References 12 publications

A New Rabies Vaccine Based on a Recombinant Orf Virus (Parapoxvirus) Expressing the Rabies Virus Glycoprotein

A New Rabies Vaccine Based on a Recombinant Orf Virus (Parapoxvirus) Expressing the Rabies Virus Glycoprotein

Relationship between Virus-Neutralizing Antibody Levels and the Number of Rabies Vaccinations: a Prospective Study of Dogs in Japan

Sero monitoring of anti rabies vaccinal antibodies to pep in animals by RFFIT - a case study in Karnataka

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