Comparison of antibacterial activity of two dentin bonding systems using agar well technique and tooth cavity model

Özer, Füsun; Karakaya, Şölen; Ünlü, Nimet; Erganiş, Osman; Kav, K.; Imazato, Satoshi

doi:10.1016/s0300-5712(03)00006-x

Cited by 31 publications

(46 citation statements)

References 17 publications

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“…This adhesive is a two-step self-etching system, employing a singlebottled 5％ MDPB-containing primer. Owing to the effects of the incorporated MDPB, the primer of Clearfil Protect Bond system shows cavitydisinfecting effects 13) . Therefore, this adhesive contributes to a reduction in the risk of secondary caries and to saving the pulp in caries treatment.…”

Section: Antibacterial Adhesive System Containing Mdpbmentioning

confidence: 99%

Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry

2009

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Restorative materials in the new era should be "bio-active", and antibacterial effects are highlighted as one of the important properties. In order to achieve resin-based restoratives with antibacterial effects, an antibacterial monomer MDPB has been developed. The primer incorporating MDPB demonstrated cavity-disinfecting effects, and the world's first antibacterial adhesive system employing the MDPB-containing primer was successfully commercialized. MDPB is potentially applicable to various restoratives since immobilization of the antibacterial component by polymerization of MDPB enables no deterioration in mechanical properties of cured resins and exhibition of inhibitory effects against bacterial growth on their surfaces. For glass-ionomer cements used for atraumatic restorative treatment, the approach to provide antibacterial activity has been attempted by addition of chlorhexidine. Incorporation of 1％ chlorhexidine diacetate was found to be optimal to give appropriate antibacterial and physical properties, being effective to reduce the bacteria in affected and infected dentin in vivo.

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Section: Antibacterial Adhesive System Containing Mdpbmentioning

confidence: 99%

Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry

2009

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“…However, the study was carried out only for planktonic bacteria, and that may be insufficient to mimic clinical circumstances. Therefore, the tooth cavity model developed by Ozer et al 23) was used to compare the antibacterial activities of urushiol with CHX and NaOCl. In their study, three cavities (diameter 1 mm, depth 2 mm) of experimental and control groups were prepared in one tooth.…”

Section: Discussionmentioning

confidence: 99%

“…Resin-based temporary restorative material (Quicks, Denkist) was used to seal the cavities even though in other studies, zinc oxidebased temporary restorative material or composite resins were used 11,12,23) . In our pilot study, which tested composite resin and zinc oxide-based material as temporary restoratives, it was revealed that overheat generation during the removal of the former and the lack of hermetic sealing property of the latter rendered them improper as temporary filling materials.…”

Section: Discussionmentioning

confidence: 99%

Effect of cavity disinfectants on antibacterial activity and microtensile bond strength in class I cavity

Kim

Shin

2017

Dent. Mater. J.

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This study was performed to compare the antibacterial activities of three cavity disinfectants [chlorhexidine (CHX), NaOCl, urushiol] and to evaluate their effect on the microtensile bond strength of Scotchbond Universal Adhesive (3M-ESPE, St. Paul, MN, USA) in class I cavities. In both experiments, class I cavities were prepared in dentin. After inoculation with Streptococcus mutans, the cavities of control group were rinsed and those of CHX, NaOCl and urushiol groups were treated with each disinfectant. Standardized amounts of dentin chips were collected and number of S. mutans was determined. Following the same cavity treatment, same adhesive was applied in etch-and-rinse mode. Then, microtensile bond strength was evaluated. The number of S. mutans was significantly reduced in the cavities treated with CHX, NaOCl, and urushiol compared with control group (p<0.05). However, there was a significant bond strength reduction in NaOCl group, which showed statistical difference compared to the other groups (p<0.05).

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“…Many studies on various properties of the HEMA-based, light-cured self-etching primer containing 5% MDPB for composite restoration are available, including demonstration of its strong antibacterial activity against cariesrelated bacteria (Imazato et al, 1997(Imazato et al, , 2004(Imazato et al, , 2014Özer et al, 2003;Carvalho et al, 2012). It has also been reported, through in vitro and in vivo studies, that incorporation of MDPB into the lightcured primer up to 5% had no adverse influences on the bonding ability to dentin (Imazato et al, 1997(Imazato et al, , 2007.…”

Section: Discussionmentioning

confidence: 99%

Development of an Antibacterial Root Canal Filling System Containing MDPB

Kitagawa

Izutani

et al. 2014

J Dent Res

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An antibacterial monomer 12-methacryloyloxydodecylpyridinum bromide (MDPB)-containing experimental, chemically cured primer was prepared to develop a new resin-based root canal filling system. This study investigated the antibacterial effects of the MDPB-containing primer (experimental primer [EP]) against Enterococcus faecalis and assessed the in vitro bonding and sealing abilities of the filling system, consisting of EP and a Bis-GMA-based sealer resin. Antibacterial effects of EP were evaluated by contact with planktonic or adherent bacteria for 30 or 60 sec, and the viable bacterial number was counted. The antibacterial effects against E. faecalis in dentinal tubules were also assessed, according to a root canal infection model. Bonding and sealing abilities of the experimental filling system were examined by microtensile bond strength tests and leakage tests based on fluid filtration methods. Significantly greater reduction in viable bacteria in planktonic and adherent form was obtained by short-period contact with EP compared with the control primer (without MDPB) or with the proprietary (Epiphany) primer (p < .05). Significantly greater bactericidal effects of the EP inside the dentinal tubule of root, as opposed to the control primer or Epiphany primer, were confirmed according to a root canal infection model (p < .05), and 100% killing of E. faecalis could be obtained by the application of EP after irrigation with a 5% sodium hypochlorite solution.The experimental endodontic filling system demonstrated significantly greater bond strength to root dentin than Epiphany sealer system (Epiphany primer and Epiphany Root Canal Sealant; p < .05), showing formation of resin tags and a hybridized layer. Leakage tests clarified that the experimental system provided excellent sealing. This study confirmed that the MDPB-containing experimental antibacterial primer has the ability to effectively disinfect the root canal. Additionally, the experimental root canal filling system employing this primer and the Bis-GMA-based sealer resin is useful for achieving good sealing, suggesting its possible benefit for successful endodontic treatments.

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Comparison of antibacterial activity of two dentin bonding systems using agar well technique and tooth cavity model

Cited by 31 publications

References 17 publications

Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry

Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry

Effect of cavity disinfectants on antibacterial activity and microtensile bond strength in class I cavity

Development of an Antibacterial Root Canal Filling System Containing MDPB

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