Comparison of antiarrhythmic activities of rihlocaine and lidocaine

Abstract

In different models of arrhythmia, the local anesthetic rihlocaine (rinocaine) exhibits a higher (or comparable) antiarrhythmic activity and therapeutic spectrum than that of lidocaine. Antiarrhythmic activity of rihlocaine may be associated with its effect on sodium and, to a greater extent, on calcium channels.

Antiarrhythmic activity of befol, suphan, mexidol, and T3-146 in combination with some antiarrhythmics

“…In this work we studied antiarrhythmic and antifibrillation activities of befol, suphan, mexidol, and T3-146 in the models of early occlusion (OA) and reperfusion arrhythmias (RA), including VF, as well as their effect on activities of antiarrhythmics of different groups according to conventional classification [15]: bonnecore (IC), obsidan (II), amiodarone (III), isoptin (IV), and a new local anesthetic richlocaine (benzoic ether 1-allyl-2,5-dimethylpiperidol-4 hydrochloride), a potent antiarrhythmic with both IB and IV types of action [7].…”