Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo

Li, Cai-Lan; Tan, Lihua; Wang, Yong-Fu; Luo, Chaodan; Chen, Hanbin; Lü, Qiang; Li, Yucui; Yang, Xiaobo; Chen, Jiannan; Liu, Yuhong; Xie, Jianhui; Su, Zi‐Ren

doi:10.1016/j.phymed.2018.09.228

Cited by 106 publications

(56 citation statements)

References 30 publications

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“…In addition, the production of interleukin 6 (IL-6) mRNA upon RSV infection is suppressed by BBR, which indicates its anti-inflammatory role during RSV infection [58]. It has been shown that BBR functions through several pathways, such as the NF-κB, ERK1/2 and p38 MAPK.…”

Section: Activity Of Bbr Against Viral-borne Respiratory Syndromesmentioning

confidence: 99%

Antiviral activity of berberine

2020

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Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19.

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Section: Activity Of Bbr Against Viral-borne Respiratory Syndromesmentioning

confidence: 99%

Antiviral activity of berberine

2020

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“…The effects of curcumin were probably prompted by enhancing the anti-oxidant enzyme activity, and activation of BDNF (Wu et al 2017). Furthermore, berberine, an isoquinoline alkaloid from different plants, with anti-in ammatory effects (Li et al 2019), improved surgery-induced cognitive impairment in aged mice (Zhang et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Postoperative cognitive recovery in children after both general and locoregional anesthesia and surgery

Hammoumi

Dahchour

Chhiti

et al. 2020

Preprint

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Background and objectivesRecent researches have demonstrated that there is a progressive impairment in neurocognitive function following general anesthesia and surgery, and particularly, have evidenced that anesthetics impaired mechanisms of learning and memory, for days to months, in both adults and children.This study aimed to evaluate the influence of different types of anesthesia (General or Locoregional) on cognitive recovery by trial and error method, and also take into consideration other factors that would have an impact on the cognitive performance after anesthesia and surgery in children.MethodsIn the present cross-sectional study, 64 young children, aged between 10 and 15 years, have passed the CALM test (software based on trial and error method) 24h after their surgery, and the operating file filled by the anesthetist. The statistical analysis includes a descriptive part of our sample, a univariate, and multivariate analysis of the results of the CALM test and the various medical factors and lifestyles.Results and conclusionsThe cognitive performance of patients exposed to locoregional anesthesia (81.3%) was higher (p=0.01) when compared to patients under general anesthesia (34.4%). Both agitation (Neurological state) and postoperative pain significantly (p=0.02) altered the cognitive performance of patients. However, none of the other factors assessed such as gender, environmental living, schooling, pre-anesthetic consultation, and the type of intervention affects the postoperative cognitive performance of patients.Locoregional anesthesia has less effect on cognitive recovery when compared to general anesthesia. Both the postoperative pain and agitation alter cognitive performances of operated children.

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“…Analysis of pharmacological activity in LPS-stimulated RAW264.7 macrophages and acute inflammation mouse models indicate that BBR and its natural derivatives have anti-inflammatory effects, with the order of oxyberberine (OBB) > BBR> reduced derivatives (two hydroquinone, DHBB) 385. The mechanisms of BBR and its derivatives involve the inhibition of the NF-κB signaling pathway 385. Further elucidation of the mechanism and therapeutic potential of BBR derivatives in cardiometabolic diseases are warranted.…”

Section: New Development Of Bbr Derivatives In Treating Cardiometabolmentioning

confidence: 99%

Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

et al. 2019

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Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is an eminent component of traditional Chinese and Ayurvedic medicine for more than 2000 years. Recently, BBR has attracted much interest for its pharmacological actions in treating and/or managing CVMD. Recent discoveries of basic, translational and clinical studies have identified many novel molecular targets of BBR (such as AMPK, SIRT1, LDLR, PCSK9, and PTP1B) and provided novel evidences supporting the promising therapeutic potential of BBR to combat CVMD. Thus, this review provides a timely overview of the pharmacological properties and therapeutic application of BBR in CVMD, and underlines recent pharmacological advances which validate BBR as a promising lead drug against CVMD.

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Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo

Cited by 106 publications

References 30 publications

Antiviral activity of berberine

Antiviral activity of berberine

Postoperative cognitive recovery in children after both general and locoregional anesthesia and surgery

Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

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