Comparison of anti-hyperglycemic effect amongst vanadium, molybdenum and other metal maltol complexes

Thompson, Katherine H.; Chiles, J.; Yuen, Violet G.; Tse, Jeremy; McNeill, John H.; Orvig, Chris

doi:10.1016/j.jinorgbio.2004.01.006

Cited by 93 publications

(60 citation statements)

References 70 publications

(119 reference statements)

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“…Specific lowering of diabetic hyperglycemia has been obtained by treatment with chromium (1,13), tungsten (17), molybdenum (36,50), and vanadium (V) compounds, with the later the most extensively studied. Although V was first used to treat diabetic patients in 1899 (33), the detailed mechanism of its antidiabetic action remains unclear.…”

mentioning

confidence: 99%

Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate

Willsky

Chi

Liang

et al. 2006

Physiological Genomics

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with vanadium, a representative of a class of antidiabetic compounds, alleviates diabetic hyperglycemia and hyperlipidemia. Oral administration of vanadium compounds in animal models and humans does not cause clinical symptoms of hypoglycemia, a common problem for diabetic patients with insulin treatment. Gene expression, using Affymetrix arrays, was examined in muscle from streptozotocin-induced diabetic and normal rats in the presence or absence of oral vanadyl sulfate treatment. This treatment affected normal rats differently from diabetic rats, as demonstrated by two-way ANOVA of the full array data. Diabetes altered the expression of 133 genes, and the expression of 30% of these genes dysregulated in diabetes was normalized by vanadyl sulfate treatment. For those genes, the ratio of expression in normal animals to the expression in diabetic animals showed a strong negative correlation with the ratio of expression in diabetic animals to the expression in diabetic animals treated with vanadyl sulfate (P ϭ Ϫ0.85). The genes identified belong to six major metabolic functional groups: lipid metabolism, oxidative stress, muscle structure, protein breakdown and biosynthesis, the complement system, and signal transduction. The identification of oxidative stress genes, coupled with the known oxidative chemistry of vanadium, implicates reactive oxygen species in the action of this class of compounds. These results imply that early transition metals or compounds formed from their chemical interactions with other metabolites may act as general transcription modulators, a role not usually associated with this class of compounds. vanadium; microarray; streptozotocin EARLY TRANSITION METALS and their complexes represent a unique class of antidiabetic agents. Specific lowering of diabetic hyperglycemia has been obtained by treatment with chromium (1, 13), tungsten (17), molybdenum (36, 50), and vanadium (V) compounds, with the later the most extensively studied. Although V was first used to treat diabetic patients in 1899 (33), the detailed mechanism of its antidiabetic action remains unclear. Inhibition of phosphotyrosine phosphatase (PTP)-1B is one mechanism by which V compounds may alleviate diabetic symptoms (16); however, alternative mechanisms could also be important contributors. Oral administration of V alleviates symptoms of diabetes in humans (9,14,15,23) and rodents (25, 35) without causing any clinical symptoms of hypoglycemia, although blood glucose levels are slightly lowered in normal animals by V treatment. This differential effect on normal (N) and diabetic (D) animals is seen with many other metabolic processes. For example, diabetic hyperlipidemia is significantly lowered by vanadyl sulfate (VS) treatment, whereas serum lipid levels in N animals are not substantially reduced by VS treatment (35). Given the importance of tight control of blood glucose levels in the diabetic patient, this class of compounds is a promising alternative for the treatment of diabetes.Various strategies are being explored to lo...

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confidence: 99%

Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate

Willsky

Chi

Liang

et al. 2006

Physiological Genomics

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“…A series of bis(maltolato)oxoyanadium(IV) (BMOV), bis(maltolato)dioxomolybdenum(VI), bis(maltolato)chromium(III), bis(maltolato)copper(II) and bis(maltolato)cobalt(II) complexes have recently reported by Thornpson et al 71 In view of insulin mimetic properties of oxovanadiurn(IV), Mohammadi et a1. 72 have synthesized novel bis(4-hydroxy-3-methoxyphenyI)-1,6-heptadiene-3,5-dione (curcumin) complexes with the formula, ML3, where M is is Ga(III) or In(III), or of the formula, ML2 where M is [VO] 2+ and characterized by mass spectrometry, infrared absorption spectroscopy and elemental analysis.…”

Section: Figure 2 a Schiff's Base Ligandmentioning

confidence: 99%

Synthesis of Schiff Base Metal Complexes: A Concise Review

Akhter¹,

Zaman²,

Mir³

et al. 2017

ECB

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“…The coordination capabilities of maltol to transition metal have been investigated for many years [1][2][3][4][5][6][7][8]. Maltol has proven to be a versatile and non-toxic chelating ligand that has made a major contribution to the bioinorganic chemistry and catalysis.…”

Section: Final Remarksmentioning

confidence: 99%

“…For instance, iron(III)-maltol complex has been used in the treatment of anemia [2] and tris (maltolato)aluminum complex has been found applications in the Alzheimer disease [3][4][5]. Perhaps the most significant is bis(maltolato)oxovanadium(IV), which has been the subject of many chemical and physiological studies due to its potent insulinomimetic properties [6][7][8]. This complex is an excellent glucose-and lipid-lowering insulin mimetics and it is currently evaluated in clinical trials [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, solution and solid state structure of titanium–maltol complex

Lamboy

Pasquale

Rheingold

et al. 2007

Inorganica Chimica Acta

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The reaction of Cp 2 TiCl 2 with two equivalents of maltol (3-hydroxy-2-methyl-4-pyrone) in water, at room temperature and pH of 5.4, leads to a complete replacement of Cp and chloride ligands affording, Ti(maltolato) 2 (OH) 2. The complex has been characterized by IR, NMR and ESI-MS spectroscopic and cyclic voltammetry methods. In DMSO-d 6 solution, the complex shows two isomers in a ratio of 4:1, in which one OH signal can be identified per isomer. This suggests that in solution the complex is monomeric, most likely a chiral cis-Ti(maltolato) 2 (OH) 2 and trans-Ti (maltolato) 2 (OH) 2 . The monomeric nature of the complex (in water/methanol 1:1) was verified by ESI-MS spectroscopy, showing a parent peak at 329 m/z. Electrochemical behavior of Ti (maltolato) 2 (OH) 2 using cyclic voltammetry experiments showed the complex undergoes irreversible reduction in aprotic solvents. In D 2 O solution, at pH of 8.4, the 1 H NMR spectrum of the complex shows a mixture of monomer and tetramer Ti(IV)-maltol complexes in a ratio of 1:1. The crystallization of Ti (maltolato) .686(7) Å, β= 97.678(4)° and V = 6824(4) Å 3 for Z = 4. Solid state structure determination of the Ti-maltol complex showed to be tetrameric, containing two bridging oxides (in cis position) and two bidentate maltol ligands per titanium in a pseudo-octahedral coordination geometry.

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Comparison of anti-hyperglycemic effect amongst vanadium, molybdenum and other metal maltol complexes

Cited by 93 publications

References 70 publications

Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate

Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate

Synthesis of Schiff Base Metal Complexes: A Concise Review

Synthesis, solution and solid state structure of titanium–maltol complex

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