Comparison of Anti‐ectoparasite and Anti‐endoparasite Therapies and Control Strategies

Woods, Debra J.; McTier, Tom L.; DeRosa, Andrew A.

doi:10.1002/9783527802883.ch1

Cited by 3 publications

(2 citation statements)

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“…Endectocides can be based on specific molecules and dosages, or on specific combinations. Resistance issues on the one handin distinct geographic regions and parasite classesand the search for broad-spectrum activity on the other hand have led increasingly to the development of products that combine two or more active ingredients from the endo-and ectoparasiticide groupings in recent years (Figure 1) [9].…”

Section: Overview Of Current Treatmentsmentioning

confidence: 99%

“…Macrocyclic lactone formulations can have activity against both nematodes and arthropods, and can therefore be used as endectoparasiticides. The ectoparasiticides comprise pyrethrins and synthetic pyrethroids, organophosphates, carbamates, macrocyclic lactones, formamidines, pyrazoles, neonicotinoids, spinosyns, semicarbazones, isoxazolines, and insect growth regulators such as the juvenile hormone analogue S-methoprene and the benzoylphenyl urea lufenuron iii [9]. The latest class, introduced into the animal health market in 2014, are the isoxazolines (Figure 3) [7].…”

Section: The Main Classes Of Antiparasiticsmentioning

confidence: 99%

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Antiparasitics in Animal Health: Quo Vadis?

Selzer

Epe

2021

Trends in Parasitology

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Antiparasitics acting on endo-or ectoparasites represent the second largest segment of the global animal health market, accounting for 23% of market share. However, relatively few novel antiparasitic agents have been introduced into the market during recent decades. One exception, and a groundbreaking 21st century success story, are the isoxazolines, whose full potential has not yet been entirely explored. Unfortunately, resistance issues are present across most parasitic diseases, which generates a clear market need for novel resistance-breaking antiparasitics with new modes/mechanisms of action. Recent advances in science and technologies strongly suggest that the time is right to invest in new modalities such as parasitic vaccines or in environmentally friendly interventions. The Animal Health IndustryAnimal health is focused on the management and control of diseases in order to ensure the health of both livestock (see Glossary) and companion animals. The global market for animal health products approaches €30 billion per year, with an annual growth rate outstripping that of human medicine. Products include biologicals (e.g., vaccines), antiparasitics/parasiticides, anti-infectives (e.g., antibiotics, antifungals), other pharmaceuticals (e.g., antihypertensives, antidiabetics), and medical feed additives (Figure 1, Key Figure). The current animal health market is understood to be driven primarily by three factors:(i) Pet owners, farmers, and veterinarians prefer more technically advanced and more convenient treatments. (ii) The growing world population increasingly demands affordable sources of protein from food animals and animal products, requiring improvements in livestock health care. (iii) The development of resistance requires new resistance-breaking preventatives and treatments.Due to the high economic impact and the immediate relevance for animal health, antiparasitics, also referred to as parasiticides, currently represent the second largest segment of the global animal health markettaking turns almost on a yearly basis with biologicals as the largest segmentaccounting for €7 billion in sales (23% of the market share) (Figures 1 and 2).In addition, animal health plays an important role in furthering the 'One Health' initiative, which is dedicated to improving the lives of all specieshuman and animalthrough the integration of human medicine, veterinary medicine, and environmental science i . The 'Antiparasitics Focus' of the Animal Health IndustryParasitic infections account for some of the most significant diseases worldwide, in both animals and humans, and are of enormous socioeconomic importance. Despite significant treatment advances in the preceding half century, they remain a major threat to livestock farming and cause large deficits for the agricultural economy. Effective parasite control is thus essential for profitability in intensive livestock production [1,2]. HighlightsAntiparasitics for the treatment of companion animals and livestock is one of the largest global market segments in the ani...

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Section: Overview Of Current Treatmentsmentioning

confidence: 99%

Section: The Main Classes Of Antiparasiticsmentioning

confidence: 99%